公开(公告)号：US20230257802A1

公开(公告)日：2023-08-17

申请号：US17990445

申请日：2022-11-18

Applicant: McMaster University

Inventor： Monsur Ali ,  Dawn White ,  Saeed Mohammadi ,  John D. Brennan ,  Yingfu Li ,  Alfredo Capretta

IPC: C12Q1/6837 ,  C12Q1/689

CPC classification number: C12Q1/6837 ,  C12Q1/689

Abstract: This disclosure relates to catalytic nucleic acid probes, biosensors and lateral flow biosensor systems and methods and kits of using the probes, biosensors and lateral flow biosensor systems for detecting microorganisms such as Staphylococcus aureus.

公开(公告)号：US20230295635A1

公开(公告)日：2023-09-21

申请号：US17966575

申请日：2022-10-14

Applicant: McMaster University

Inventor： John D. Brennan ,  Monsur Ali ,  Michael Wolfe ,  Dawn White ,  Manali Mukherjee ,  Parameswaran Nair ,  Alfredo Capretta

IPC: C12N15/115 ,  C12Q1/28

CPC classification number: C12N15/115 ,  C12Q1/28 ,  C12N2310/16

Abstract: This disclosure relates to DNA aptamers that bind eosinophil peroxidase, including uses thereof, such as in eosinophil peroxidase detection assays. Also provided is a method for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase. Further provided is a kit for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase.

公开(公告)号：US11549945B2

公开(公告)日：2023-01-10

申请号：US16875707

申请日：2020-05-15

Applicant: McMaster University

Inventor： John D. Brennan ,  Yingfu Li ,  Monsur Ali ,  Carlos Filipe ,  Michael Gregory Wolfe

IPC: C12Q1/6816 ,  G01N33/569 ,  G01N33/543

Abstract: Provided herein are nucleic acid-cleaving catalytic nucleic acid probes, biosensors and lateral flow biosensor devices and methods and kits of using the probes, biosensors and lateral flow biosensor devices for detecting an analyte present on or generated from a microorganism in a test sample, including Helicobacter pylori and methods for determining whether a subject has a Helicobacter pylori infection.

公开(公告)号：US20200256860A1

公开(公告)日：2020-08-13

申请号：US16786049

申请日：2020-02-10

Applicant: McMaster University

Inventor： Rabia Mateen ,  Monsur Ali ,  Todd Hoare

IPC: G01N33/544 ,  C12Q1/34 ,  C08F220/28 ,  C08J3/24 ,  C08J3/075

Abstract: The invention pertains to a printable hydrogel that can both immobilize and stabilize a wide range of biomolecules and/or cells on a substrate while restricting the access of surrounding chemicals to the biomolecule active site. Such hydrogels can be adapted to high-throughput screening applications and can discriminate between true inhibitors and promiscuous aggregating inhibitors as well as enable the determination of dose-response relationships of biomolecule and/or cell inhibitory chemicals with high accuracy.