公开(公告)号：US11744938B2

公开(公告)日：2023-09-05

申请号：US17001192

申请日：2020-08-24

Applicant: Medtronic, Inc.

Inventor： Michael C. Schmitz ,  Dale F. Seeley ,  Keith R. Hildebrand

IPC: A61M5/142 ,  A61M5/172 ,  A61M5/168 ,  G16H20/17

CPC classification number: A61M5/14248 ,  A61M5/1723 ,  G16H20/17 ,  A61M5/14276 ,  A61M5/16827 ,  A61M2005/14208 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50

Abstract: Titration schemes are carried out by medical infusion devices, such as ambulatory or implantable infusion devices. The titration schemes carried out by infusion systems and devices may take into account patient side effects in controlling the rate at which a medicament is delivered from the devices of systems.

公开(公告)号：US09707338B2

公开(公告)日：2017-07-18

申请号：US14063870

申请日：2013-10-25

Applicant: MEDTRONIC, INC.

Inventor： Dale F. Seeley ,  Michael C. Schmitz ,  Keith R. Hildebrand ,  Edwin Rivera

IPC: A61M5/14 ,  A61M5/142 ,  A61M5/168

CPC classification number: A61M5/14248 ,  A61M5/1413 ,  A61M5/16877 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/586 ,  A61M2205/59

Abstract: An ambulatory infusion device includes a common module having a pump mechanism and a fluid flow path in communication with the pump mechanism. The device also includes a custom module operably coupleable to the common module. The custom module includes a reservoir for housing a liquid composition comprising a medicament and control electronics. The reservoir is configured to fluidly couple with the fluid flow path, and the control electronics are configured to electrically couple to the pump mechanism when the common module and the custom module are operably coupled. When the common module and the custom module are operably coupled, the pump mechanism is configured to drive the liquid composition from the reservoir to a patient via the fluid flow path, and the control electronics are configured to control the rate at which the pump mechanism drives the liquid composition.

公开(公告)号：US09155695B2

公开(公告)日：2015-10-13

申请号：US13828148

申请日：2013-03-14

Applicant: Medtronic, Inc.

Inventor： Michael C. Schmitz ,  Roger E. Harrington ,  Carmen E. Snaza ,  Keith R. Hildebrand ,  Ngoc N. Lu

IPC: A01N43/38 ,  A61K31/40 ,  A61K9/00 ,  A61K31/4045 ,  A61K9/19 ,  A61K47/12

CPC classification number: A61K9/0019 ,  A61K9/19 ,  A61K31/4045 ,  A61K47/12

Abstract: Compositions and methods are provided that utilize an injectable ropinirole having a therapeutically effective amount of ropinirole in an aqueous solvent, the composition having a pH of from about 3.0 to about 6.5. The compositions and methods provided contain less than 3% by weight of impurities and are suitable for administration by infusion pumps. In some embodiments, the compositions are made in an oxygen free environment and/or are made with an antioxidant to reduce impurities and improve stability. In some embodiments, the compositions provided are utilized to treat Parkinson's disease.

Abstract translation: 提供了组合物和方法，其利用在含水溶剂中具有治疗有效量的罗哌尼罗的可注射的罗匹尼罗，所述组合物具有约3.0至约6.5的pH。 所提供的组合物和方法含有少于3重量％的杂质，并且适合于输液泵的给药。 在一些实施方案中，组合物在无氧环境中制备和/或由抗氧化剂制成以减少杂质并提高稳定性。 在一些实施方案中，所提供的组合物用于治疗帕金森病。

公开(公告)号：US20150119821A1

公开(公告)日：2015-04-30

申请号：US14063883

申请日：2013-10-25

Applicant: MEDTRONIC, INC.

Inventor： Michael C. Schmitz ,  Dale F. Seeley ,  Keith R. Hildebrand

IPC: A61M5/168 ,  B65B3/04 ,  B65B55/12 ,  A61M5/14

CPC classification number: B65B55/12 ,  A61M5/14248 ,  A61M2005/14268 ,  A61M2205/6045 ,  A61M2209/045 ,  B65B3/003 ,  B65B3/04

Abstract: Prefilled reservoir apparatuses for use in ambulatory infusion devices include a rigid top and a flexible bag that forms at least a portion of a reservoir containing a liquid medicament composition. The reservoir apparatuses include a septum assembly that includes a fluid flow path in communication with the reservoir and a self-sealing septum disposed in or over the fluid flow path. The septum is positioned and configured to be pierced by a cannula of a base of an infusion device when the reservoir apparatus is received by the base.

Abstract translation: 用于动态输液装置的预充储存装置包括刚性顶部和形成至少一部分包含液体药物组合物的储存器的柔性袋。 储存装置包括隔膜组件，其包括与储存器连通的流体流动路径和设置在流体流动路径中或上方的自密封隔膜。 当储存装置被基座接收时，隔膜被定位和构造成被输注装置的基座的套管刺穿。

公开(公告)号：US20150374665A1

公开(公告)日：2015-12-31

申请号：US14852039

申请日：2015-09-11

Applicant: Medtronic, Inc.

Inventor： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

IPC: A61K31/4168 ,  A61K47/34

CPC classification number: A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

Abstract: Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

Abstract translation: 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

公开(公告)号：US20150032053A1

公开(公告)日：2015-01-29

申请号：US13953108

申请日：2013-07-29

Applicant: MEDTRONIC, INC.

Inventor： Michael C. Schmitz ,  Dale F. Seeley ,  Keith R. Hildebrand

IPC: A61M5/168

CPC classification number: A61M5/14248 ,  A61M5/14276 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50 ,  G06F19/3468

Abstract: Titration schemes are carried out by medical infusion devices, such as ambulatory or implantable infusion devices. The titration schemes carried out by infusion systems and devices may take into account patient side effects in controlling the rate at which a medicament is delivered from the devices of systems.

Abstract translation: 滴定方案由医用输液装置进行，例如流动或植入式输注装置。 由输注系统和装置进行的滴定方案可以考虑患者在控制药物从系统装置输送的速率方面的副作用。

公开(公告)号：US09463889B2

公开(公告)日：2016-10-11

申请号：US14063883

申请日：2013-10-25

Applicant: MEDTRONIC, INC.

Inventor： Michael C. Schmitz ,  Dale F. Seeley ,  Keith R. Hildebrand

IPC: B65B55/12 ,  B65B3/04 ,  B65B3/00 ,  A61M5/142

CPC classification number: B65B55/12 ,  A61M5/14248 ,  A61M2005/14268 ,  A61M2205/6045 ,  A61M2209/045 ,  B65B3/003 ,  B65B3/04

Abstract: Prefilled reservoir apparatuses for use in ambulatory infusion devices include a rigid top and a flexible bag that forms at least a portion of a reservoir containing a liquid medicament composition. The reservoir apparatuses include a septum assembly that includes a fluid flow path in communication with the reservoir and a self-sealing septum disposed in or over the fluid flow path. The septum is positioned and configured to be pierced by a cannula of a base of an infusion device when the reservoir apparatus is received by the base.

Abstract translation: 用于动态输液装置的预充储存装置包括刚性顶部和形成至少一部分包含液体药物组合物的储存器的柔性袋。 储存装置包括隔膜组件，其包括与储存器连通的流体流动路径和设置在流体流动路径中或上方的自密封隔膜。 当储存装置被基座接收时，隔膜被定位和构造成被输注装置的基座的套管刺穿。

公开(公告)号：US20140275202A1

公开(公告)日：2014-09-18

申请号：US13828148

申请日：2013-03-14

Applicant: MEDTRONIC, INC.

Inventor： Michael C. Schmitz ,  Roger E. Harrington ,  Carmen E. Snaza ,  Keith R. Hildebrand ,  Ngoc N. Lu

IPC: A61K9/00 ,  A61K31/4045

CPC classification number: A61K9/0019 ,  A61K9/19 ,  A61K31/4045 ,  A61K47/12

Abstract: Compositions and methods are provided that utilize an injectable ropinirole having a therapeutically effective amount of ropinirole in an aqueous solvent, the composition having a pH of from about 3.0 to about 6.5. The compositions and methods provided contain less than 3% by weight of impurities and are suitable for administration by infusion pumps. In some embodiments, the compositions are made in an oxygen free environment and/or are made with an antioxidant to reduce impurities and improve stability. In some embodiments, the compositions provided are utilized to treat Parkinson's disease.

Abstract translation: 提供了组合物和方法，其利用在含水溶剂中具有治疗有效量的罗哌尼罗的可注射的罗匹尼罗，所述组合物具有约3.0至约6.5的pH。 所提供的组合物和方法含有少于3重量％的杂质，并且适合于输液泵的给药。 在一些实施方案中，组合物在无氧环境中制备和/或由抗氧化剂制成以减少杂质并提高稳定性。 在一些实施方案中，所提供的组合物用于治疗帕金森病。

公开(公告)号：US09770438B2

公开(公告)日：2017-09-26

申请号：US14852039

申请日：2015-09-11

Applicant: Medtronic, Inc.

Inventor： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

IPC: A01N43/50 ,  A61K31/415 ,  A61K31/4168 ,  A61K9/00 ,  A61K9/16 ,  A61K47/34 ,  A61K9/06

CPC classification number: A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

Abstract: Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

公开(公告)号：US20150119804A1

公开(公告)日：2015-04-30

申请号：US14063870

申请日：2013-10-25

Applicant: MEDTRONIC, INC.

Inventor： Dale F. Seeley ,  Michael C. Schmitz ,  Keith R. Hildebrand ,  Edwin Rivera

IPC: A61M5/168

CPC classification number: A61M5/14248 ,  A61M5/1413 ,  A61M5/16877 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/586 ,  A61M2205/59

Abstract: An ambulatory infusion device includes a common module having a pump mechanism and a fluid flow path in communication with the pump mechanism. The device also includes a custom module operably coupleable to the common module. The custom module includes a reservoir for housing a liquid composition comprising a medicament and control electronics. The reservoir is configured to fluidly couple with the fluid flow path, and the control electronics are configured to electrically couple to the pump mechanism when the common module and the custom module are operably coupled. When the common module and the custom module are operably coupled, the pump mechanism is configured to drive the liquid composition from the reservoir to a patient via the fluid flow path, and the control electronics are configured to control the rate at which the pump mechanism drives the liquid composition.

Abstract translation: 流动输液装置包括具有泵机构和与泵机构连通的流体流路的公共模块。 该设备还包括可操作地连接到公共模块的定制模块。 定制模块包括用于容纳包含药物和控制电子器件的液体组合物的储存器。 储存器构造成与流体流动路径流体耦合，并且控制电子设备被配置为当公共模块和定制模块可操作地耦合时电耦合到泵机构。 当共用模块和定制模块可操作地耦合时，泵机构构造成经由流体流动路径将液体组合物从储存器驱动到患者，并且控制电子设备被配置为控制泵机构驱动的速率 液体组成。