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公开(公告)号：US20190159884A1
公开(公告)日：2019-05-30
申请号：US16144078
申请日：2018-09-27
发明人： Keith Perkins , Zachary Borglin , Julie Benton , Matt Petruska , Darren Galligan , Samuel Robaina , Rajesh Radhakrishnan
摘要： The techniques of this disclosure generally relate to prosthesis formed from a biodegradable composite yarn. The biodegradable composite yarn includes a permanent core and a biodegradable shell. The biodegradable shell slowly dissolves over a period of time when placed in a vessel. As the biodegradable shell dissolves, openings are created in the prosthesis that are filled with tissue from the vessel wall of the vessel. The integration of the tissue into the prosthesis provides biological fixation of prosthesis in the vessel and prevents endoleaks and migration of prosthesis.
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公开(公告)号：US20190110884A1
公开(公告)日：2019-04-18
申请号：US16219312
申请日：2018-12-13
发明人： Keith Perkins , Jeffery Argentine , Matt Petruska , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
摘要： A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.
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公开(公告)号：US20170231749A1
公开(公告)日：2017-08-17
申请号：US15043246
申请日：2016-02-12
发明人： Keith Perkins , Jeffery Argentine , Matt Petruska , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
IPC分类号： A61F2/07
CPC分类号： A61F2/07 , A61F2/0077 , A61F2002/065 , A61F2002/068 , A61F2002/075 , A61F2002/077 , A61F2210/0061 , A61F2230/0065 , A61F2250/0051 , A61F2250/0056 , A61F2310/00023
摘要： A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.
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公开(公告)号：US11938249B2
公开(公告)日：2024-03-26
申请号：US16928080
申请日：2020-07-14
发明人： Jeffery Argentine , Matt Petruska , Keith Perkins , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
CPC分类号： A61L27/56 , A61F2/06 , A61F2/07 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/16 , A61F2002/072 , A61F2002/077 , A61F2210/0061 , A61L2300/42
摘要： The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.
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公开(公告)号：US10939990B2
公开(公告)日：2021-03-09
申请号：US15950612
申请日：2018-04-11
发明人： Zachary Borglin , Matt Petruska , Keith Perkins , Julie Benton
IPC分类号： A61F2/07 , D02G3/36 , A61L27/58 , D03D1/00 , D03D15/00 , A61F2/06 , D02G3/44 , A61F2/00 , A61L27/18 , A61L27/54 , A61L27/56 , A61L31/14 , A61L31/16 , A61L31/02 , A61L31/06 , A61L31/10 , B23K26/388 , A61L31/04
摘要： A laser is used to form openings within a graft material to selectively enhance permeability of a prosthesis for tissue integration therein. A feature of utilizing a laser to create the openings for tissue integration builds from its tunability. More particularly, the laser precisely places openings in any pattern and location, and on any textile that forms the graft material. Further, the power and focus of the laser is precisely adjusted to control the diameter and shape of the openings. All parameters of the openings can be controlled at will, allowing for the opportunity to selectively enhance and optimize the permeability of the graft material in a vessel.
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公开(公告)号：US20190159882A1
公开(公告)日：2019-05-30
申请号：US16143125
申请日：2018-09-26
发明人： Keith Perkins , Zachary Borglin , Julie Benton , Matt Petruska , Darren Galligan , Samuel Robaina , Rajesh Radhakrishnan
IPC分类号： A61F2/07
摘要： The techniques of this disclosure generally relate to a prosthesis including framed biodegradable yarn graft material having a frame and biodegradable yarns combined with the frame. The biodegradable yarns seal tissue integration openings within the frame. The frame provides long term mechanical strength while the biodegradable yarns provide acute strength and impermeability to prevent endoleaks. As the biodegradable yarns degrade, the drop in textile density creates tissue integration openings, through which tissue grows. The integrate of tissue into the framed biodegradable yarn graft material provides biological fixation of the prosthesis in vessels and prevents endoleaks and migration of the prosthesis.
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公开(公告)号：US20190160208A1
公开(公告)日：2019-05-30
申请号：US16142545
申请日：2018-09-26
发明人： Keith Perkins , Zachary Borglin , Julie Benton , Matt Petruska , Darren Galligan , Samuel Robaina , Rajesh Radhakrishnan
摘要： The techniques of this disclosure generally relate to applying an armor coating to a graft material. The armor coating is armor, impermeable to fluid, and elastic. The armor coating seals openings within the graft material eliminating passage of fluid through the graft material.
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公开(公告)号：US10188500B2
公开(公告)日：2019-01-29
申请号：US15043246
申请日：2016-02-12
发明人： Keith Perkins , Jeffery Argentine , Matt Petruska , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
摘要： A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.
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公开(公告)号：US20170360993A1
公开(公告)日：2017-12-21
申请号：US15621637
申请日：2017-06-13
发明人： Jeffery Argentine , Matt Petruska , Keith Perkins , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
CPC分类号： A61L27/56 , A61F2/06 , A61F2/07 , A61F2002/072 , A61F2002/077 , A61F2210/0061 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/16 , A61L2300/42
摘要： The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.
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