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公开(公告)号：US20190110884A1
公开(公告)日：2019-04-18
申请号：US16219312
申请日：2018-12-13
发明人： Keith Perkins , Jeffery Argentine , Matt Petruska , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
摘要： A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.
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公开(公告)号：US20170231749A1
公开(公告)日：2017-08-17
申请号：US15043246
申请日：2016-02-12
发明人： Keith Perkins , Jeffery Argentine , Matt Petruska , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
IPC分类号： A61F2/07
CPC分类号： A61F2/07 , A61F2/0077 , A61F2002/065 , A61F2002/068 , A61F2002/075 , A61F2002/077 , A61F2210/0061 , A61F2230/0065 , A61F2250/0051 , A61F2250/0056 , A61F2310/00023
摘要： A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.
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公开(公告)号：US11938249B2
公开(公告)日：2024-03-26
申请号：US16928080
申请日：2020-07-14
发明人： Jeffery Argentine , Matt Petruska , Keith Perkins , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
CPC分类号： A61L27/56 , A61F2/06 , A61F2/07 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/16 , A61F2002/072 , A61F2002/077 , A61F2210/0061 , A61L2300/42
摘要： The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.
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公开(公告)号：US20190159882A1
公开(公告)日：2019-05-30
申请号：US16143125
申请日：2018-09-26
发明人： Keith Perkins , Zachary Borglin , Julie Benton , Matt Petruska , Darren Galligan , Samuel Robaina , Rajesh Radhakrishnan
IPC分类号： A61F2/07
摘要： The techniques of this disclosure generally relate to a prosthesis including framed biodegradable yarn graft material having a frame and biodegradable yarns combined with the frame. The biodegradable yarns seal tissue integration openings within the frame. The frame provides long term mechanical strength while the biodegradable yarns provide acute strength and impermeability to prevent endoleaks. As the biodegradable yarns degrade, the drop in textile density creates tissue integration openings, through which tissue grows. The integrate of tissue into the framed biodegradable yarn graft material provides biological fixation of the prosthesis in vessels and prevents endoleaks and migration of the prosthesis.
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公开(公告)号：US10595981B2
公开(公告)日：2020-03-24
申请号：US15238538
申请日：2016-08-16
摘要： The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having a graft material and a stent structure attached with a suture, or a seam formed by a suture, where the suture has a coating that expands upon exposure to body fluids. The expansion allows for the coating to fill suture holes in the graft material so as to reduce or eliminate endoleaks.
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公开(公告)号：US11147952B2
公开(公告)日：2021-10-19
申请号：US15141355
申请日：2016-04-28
发明人： Adam Shipley , Tony Le , Rajesh Radhakrishnan , Terry Morgan
摘要： A medical device includes an inflatable balloon defining an interior surface and an exterior surface, and a coating including a therapeutic agent disposed on the exterior surface of the inflatable balloon. The coating has a release transition temperature within a range from about 25° C. to about 50° C. When the temperature of the coating is below the release transition temperature, the coating retains at least a portion of the therapeutic agent on the exterior of the inflatable balloon. When the temperature of the coating is above the release transition temperature, the coating releases at least a portion of the therapeutic agent from the exterior of the inflatable balloon.
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公开(公告)号：US20190160208A1
公开(公告)日：2019-05-30
申请号：US16142545
申请日：2018-09-26
发明人： Keith Perkins , Zachary Borglin , Julie Benton , Matt Petruska , Darren Galligan , Samuel Robaina , Rajesh Radhakrishnan
摘要： The techniques of this disclosure generally relate to applying an armor coating to a graft material. The armor coating is armor, impermeable to fluid, and elastic. The armor coating seals openings within the graft material eliminating passage of fluid through the graft material.
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公开(公告)号：US10188500B2
公开(公告)日：2019-01-29
申请号：US15043246
申请日：2016-02-12
发明人： Keith Perkins , Jeffery Argentine , Matt Petruska , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
摘要： A scaffolded stent-graft includes a graft material comprising an inner surface and an outer surface. The inner surface defines a lumen within the graft material. The scaffolded stent-graft further includes a scaffold comprising a mesh coupled to the graft material at the outer surface. The scaffold is configured to promote tissue ingrowth therein. In this manner, the scaffold enhances tissue integration into the scaffolded stent-graft. The tissue integration enhances biological fixation of the scaffolded stent-graft in vessels minimizing the possibility of endoleaks and migration.
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公开(公告)号：US20170360993A1
公开(公告)日：2017-12-21
申请号：US15621637
申请日：2017-06-13
发明人： Jeffery Argentine , Matt Petruska , Keith Perkins , Samuel Robaina , Darren Galligan , Rajesh Radhakrishnan
CPC分类号： A61L27/56 , A61F2/06 , A61F2/07 , A61F2002/072 , A61F2002/077 , A61F2210/0061 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/16 , A61L2300/42
摘要： The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures. The hydrogel compositions can also include various stabilizing polymers and active agents to further aid their use in the body.
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公开(公告)号：US20190159884A1
公开(公告)日：2019-05-30
申请号：US16144078
申请日：2018-09-27
发明人： Keith Perkins , Zachary Borglin , Julie Benton , Matt Petruska , Darren Galligan , Samuel Robaina , Rajesh Radhakrishnan
摘要： The techniques of this disclosure generally relate to prosthesis formed from a biodegradable composite yarn. The biodegradable composite yarn includes a permanent core and a biodegradable shell. The biodegradable shell slowly dissolves over a period of time when placed in a vessel. As the biodegradable shell dissolves, openings are created in the prosthesis that are filled with tissue from the vessel wall of the vessel. The integration of the tissue into the prosthesis provides biological fixation of prosthesis in the vessel and prevents endoleaks and migration of prosthesis.
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