公开(公告)号：US20090032700A1

公开(公告)日：2009-02-05

申请号：US12172605

申请日：2008-07-14

申请人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

发明人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/4295 ,  H01J49/424

摘要： In a three-dimensional Paul RF ion trap at least one of the ring electrode and end cap electrodes is structured to produce a high capture efficiency for analyte ions introduced into the trap. The electrode structuring may be produced by an electrode surface profile having edges or protrusions, resulting in a scattering reflection of the introduced ions. Alternatively, at least one electrode may be formed by physically separate electrode components. In one embodiment, the trap can be switched between operating as a linear ion trap with good capture efficiency and operating as a three-dimensional ion trap with good ion reaction conditions.

摘要翻译： 在三维Paul RF离子阱中，环形电极和端盖电极中的至少一个被构造成为引入陷阱的分析物离子产生高捕获效率。 电极结构可以通过具有边缘或突起的电极表面轮廓来产生，导致引入离子的散射反射。 或者，可以通过物理分离的电极组件形成至少一个电极。 在一个实施例中，可以在具有良好捕获效率的线性离子阱之间切换陷阱，并且作为具有良好离子反应条件的三维离子阱操作。

公开(公告)号：US08164056B2

公开(公告)日：2012-04-24

申请号：US12854493

申请日：2010-08-11

申请人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

发明人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

IPC分类号： H01J49/42

CPC分类号： H01J49/4295 ,  H01J49/424

摘要： In a three-dimensional Paul RF ion trap the ring electrode and end cap electrodes are formed from pairs of pole rods. This multipole rod system is then operated as a linear ion trap with a constant field distribution along the multipole rod system. While the system is operating as a linear ion trap, analyte ions are introduced and stored within the linear ion trap. After the ions have been stored, a single-phase RF voltage is supplied to all rods of a middle segment thus forming a three-dimensional ion trap, thereby collecting the ions in a spherical cloud within this middle segment. The collected analyte ions can then be reacted in the three-dimensional ion trap and the product ions resulting from the reactions can be ejected for mass analysis.

摘要翻译： 在三维Paul RF离子阱中，环形电极和端盖电极由极棒对形成。 然后，该多极棒系统沿着多极杆系统作为具有恒定场分布的线性离子阱操作。 当系统作为线性离子阱操作时，分析物离子被引入并存储在线性离子阱内。 在离子被储存之后，单相RF电压被提供给中间段的所有棒，从而形成三维离子阱，从而在该中间段内将离子收集在球形云中。 收集的分析物离子然后可以在三维离子阱中反应，并且可以喷射由反应产生的产物离子进行质量分析。

公开(公告)号：US20110139976A1

公开(公告)日：2011-06-16

申请号：US12854493

申请日：2010-08-11

申请人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

发明人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

IPC分类号： B01D59/44

CPC分类号： H01J49/4295 ,  H01J49/424

摘要： In a three-dimensional Paul RF ion trap the ring electrode and end cap electrodes are formed from pairs of pole rods. This multipole rod system is then operated as a linear ion trap with a constant field distribution along the multipole rod system. While the system is operating as a linear ion trap, analyte ions are introduced and stored within the linear ion trap. After the ions have been stored, a single-phase RF voltage is supplied to all rods of a middle segment thus forming a three-dimensional ion trap, thereby collecting the ions in a spherical cloud within this middle segment. The collected analyte ions can then be reacted in the three-dimensional ion trap and the product ions resulting from the reactions can be ejected for mass analysis.

摘要翻译： 在三维Paul RF离子阱中，环形电极和端盖电极由极棒对形成。 然后，该多极棒系统沿着多极杆系统作为具有恒定场分布的线性离子阱操作。 当系统作为线性离子阱操作时，分析物离子被引入并存储在线性离子阱内。 在离子被储存之后，单相RF电压被提供给中间段的所有棒，从而形成三维离子阱，从而将该离子收集在该中间段内的球形云中。 收集的分析物离子然后可以在三维离子阱中反应，并且可以喷射由反应产生的产物离子进行质量分析。

公开(公告)号：US07872229B2

公开(公告)日：2011-01-18

申请号：US12172605

申请日：2008-07-14

申请人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

发明人： Melvin A. Park ,  Michael Schubert ,  Jochen Franzen

IPC分类号： H01J49/42

CPC分类号： H01J49/4295 ,  H01J49/424

摘要： In a three-dimensional Paul RF ion trap at least one of the ring electrode and end cap electrodes is structured to produce a high capture efficiency for analyte ions introduced into the trap. The electrode structuring may be produced by an electrode surface profile having edges or protrusions, resulting in a scattering reflection of the introduced ions. Alternatively, at least one electrode may be formed by physically separate electrode components. In one embodiment, the trap can be switched between operating as a linear ion trap with good capture efficiency and operating as a three-dimensional ion trap with good ion reaction conditions.

摘要翻译： 在三维Paul RF离子阱中，环形电极和端盖电极中的至少一个被构造成为引入陷阱的分析物离子产生高捕获效率。 电极结构可以通过具有边缘或突起的电极表面轮廓来产生，导致引入离子的散射反射。 或者，可以通过物理分离的电极组件形成至少一个电极。 在一个实施例中，可以在具有良好捕获效率的线性离子阱之间切换陷阱，并且作为具有良好离子反应条件的三维离子阱操作。

公开(公告)号：US06989534B2

公开(公告)日：2006-01-24

申请号：US10849499

申请日：2004-05-19

申请人： Michael Schubert ,  Jochen Franzen

发明人： Michael Schubert ,  Jochen Franzen

IPC分类号： H01J49/42

CPC分类号： H01J49/424 ,  H01J49/067 ,  H01J49/4295

摘要： The invention relates to methods and devices for the effective capturing of externally generated ions in an RF operated quadrupole ion trap. The invention involves applying a voltage consisting of positive and negative pulses, instead of a sinusoidal RF voltage, during the capturing process, with capturing intervals between each pulse in which the voltage is low.

摘要翻译： 本发明涉及用于在RF操作的四极离子阱中有效捕获外部产生的离子的方法和装置。 本发明涉及在捕获过程期间施加由正脉冲和负脉冲组成的电压而不是正弦RF电压，其中电压低的每个脉冲之间的捕获间隔。

公开(公告)号：US5654542A

公开(公告)日：1997-08-05

申请号：US588209

申请日：1996-01-19

申请人： Michael Schubert ,  Jochen Franzen

发明人： Michael Schubert ,  Jochen Franzen

IPC分类号： H01J49/42

CPC分类号： H01J49/428

摘要： A method for the simultaneous resonant excitation of the oscillations of ions of various mass-to-charge ratios in ion traps, particularly for the ejection of undesirable ion species, by applying RF frequencies with various frequency components to electrodes of the ion trap. The method consists in generating and storing a broadband signal for as short a time as possible so that it can be fed to the ion trap a number of times in succession cyclically, without generating undesirable interference due to phase shifts. The excitation of the ions should be as temporally constant as possible throughout the waveform period. The duration of the waveform period depends on the mass resolution required. Excitation is terminated by controlling the broadband signal gradually toward zero in a constant function.

摘要翻译： 通过将具有各种频率分量的RF频率施加到离子阱的电极，同时共振激发离子阱中各种质荷比的离子的振荡，特别是用于喷射不期望的离子种类的方法。 该方法包括在尽可能短的时间内产生和存储宽带信号，使得其可以循环地连续多次馈送到离子阱，而不会由于相移而产生不期望的干扰。 在整个波形周期内，离子的激发应该尽可能地保持恒定。 波形周期的持续时间取决于所需的质量分辨率。 通过在恒定功能中将宽带信号逐渐向零控制来终止激励。

公开(公告)号：US06410913B1

公开(公告)日：2002-06-25

申请号：US09613614

申请日：2000-07-11

申请人： Andreas Brekenfeld ,  Michael Schubert ,  Jochen Franzen

发明人： Andreas Brekenfeld ,  Michael Schubert ,  Jochen Franzen

IPC分类号： H01J4942

CPC分类号： H01J49/0063 ,  H01J49/424

摘要： The invention relates to the fragmentation of ions in ion traps filled with collision gas by exciting their axial oscillations in a dipole-shaped excitation field with a frequency mixture which covers the frequency of ion oscillations. The invention consists of ramping up the voltages of the frequency mixture for the dipolar excitation field, as a result of which, surprisingly, approximately the same fragmentation results are obtained for ions of different structures in the same fragmentation times as at a structurally specific optimal voltage applied at a constant level.

摘要翻译： 本发明涉及通过在具有覆盖离子振荡频率的频率混合物的偶极子形激发场中激发它们的轴向振荡来使填充有碰撞气体的离子阱中的离子的分裂。 本发明包括提高用于偶极激发场的频率混合的电压，结果令人惊奇的是，在与结构上特定的最佳电压相同的断裂时间中获得与不同结构的离子大致相同的断裂结果 应用在一个恒定的水平。

公开(公告)号：US20050023461A1

公开(公告)日：2005-02-03

申请号：US10849499

申请日：2004-05-19

申请人： Michael Schubert ,  Jochen Franzen

发明人： Michael Schubert ,  Jochen Franzen

IPC分类号： G01N23/00 ,  H01J49/42

CPC分类号： H01J49/424 ,  H01J49/067 ,  H01J49/4295

摘要： The invention relates to methods and devices for the effective capturing of externally generated ions in an RF operated quadrupole ion trap. The invention involves applying a voltage consisting of positive and negative pulses, instead of a sinusoidal RF voltage, during the capturing process, with capturing intervals between each pulse in which the voltage is low.

摘要翻译： 本发明涉及用于在RF操作的四极离子阱中有效捕获外部产生的离子的方法和装置。 本发明涉及在捕获过程期间施加由正脉冲和负脉冲组成的电压而不是正弦RF电压，其中电压低的每个脉冲之间的捕获间隔。

公开(公告)号：US5936241A

公开(公告)日：1999-08-10

申请号：US32579

申请日：1998-02-27

申请人： Jochen Franzen ,  Michael Schubert

发明人： Jochen Franzen ,  Michael Schubert

IPC分类号： H01J49/42

CPC分类号： H01J49/4265

摘要： The invention consists of deriving the control of the space charge in the ion trap for the initial daughter ion spectrum from the filling rates of previous normal spectra, from the abundance ratio of the parent ions to be isolated to the total ions in the spectrum, and from the at least roughly known isolation and fragmentation yields. For further daughter ion spectra, the resulting measured overall filling rate with daughter ions may be used. The same applies in an analogue way to spectra of isolated ions or of ions from MS.sup.n processes.

摘要翻译： 本发明包括从先前正常光谱的填充率，从要分离的母离子的丰度比与光谱中的总离子的丰度比，导出离子阱中离子阱中空间电荷的控制，以及 从至少大致已知的分离和碎裂产率。 对于更多的子离子光谱，可以使用与子离子的测得的总体填充率。 同样的情况也适用于分离离子或MSn过程离子的光谱。

公开(公告)号：US5811800A

公开(公告)日：1998-09-22

申请号：US713812

申请日：1996-09-13

申请人： Jochen Franzen ,  Michael Schubert

发明人： Jochen Franzen ,  Michael Schubert

IPC分类号： H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/062 ,  H01J49/422

摘要： The invention relates to methods and devices for the temporary storage of ions which are to be subjected to mass spectrometric analysis. Such temporary storage of ions in an RF multipole rod system for their analysis in an RF quadrupole ion trap is known from U.S. Pat. No. 5,179,278. The invention uses this known temporary storage for such ions which are produced in an ion source from substance peaks from chromatographic or electrophoretich separation devices, or from other devices which feed substances in form of short-lasting peaks. The temporary store thereby accepts sufficient ions of a substance peak for several successive mass spectrometric analyses, so that a mass spectrometric characterization of the substances, which may also require varying measurement methods, is made possible to the desired degree. Particularly ions from electrophoretically or chromatographically separated substance peaks should be able to be temporarily stored long enough until the mass spectrometric analyses have been concluded to the desired extent. Several temporary stores can collect the ions from several rapidly successive substance peaks. However, short-lasting substance peaks from laser desorptive or pyrolitic processes can also be thoroughly analyzed by means of temporary storage.

摘要翻译： 本发明涉及临时储存待进行质谱分析的离子的方法和装置。 在RF多极杆系统中这样的临时存储离子在RF四极杆离子阱中进行分析是已知的。 第5,179,278号。 本发明使用这种已知的临时储存用于离子源中产生的这些离子，所述离子源来自色谱或电泳分离装置的物质峰，或者从其它以短持久峰形式供给物质的装置。 临时存储器由此接受足够的物质峰离子以进行几次连续的质谱分析，使得可能需要改变测量方法的物质的质谱表征成为可能达到期望的程度。 特别是来自电泳或色谱分离的物质峰的离子应该能够被暂时保存足够长的时间，直到质谱分析已经达到预期的程度。 几个临时商店可以从几个快速连续的物质峰中收集离子。 然而，也可以通过临时储存来彻底地分析来自激光解吸或热解过程的短暂物质峰。