公开(公告)号：US20210300940A1

公开(公告)日：2021-09-30

申请号：US17250489

申请日：2019-07-29

申请人： Merck Patent GmbH

发明人： Brian Sherer ,  Ruoxi Lan ,  Nadia Brugger ,  Xiaoling Chen ,  Momar Toure ,  Esther Cleary ,  Lizbeth Celeste Deselm ,  Yanping Wang

IPC分类号： C07D495/10 ,  C07D401/14 ,  C07D401/04 ,  C07D471/04 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/10 ,  C07D417/14

摘要： Compounds of Formula (I) and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists.

公开(公告)号：US11001561B2

公开(公告)日：2021-05-11

申请号：US16843735

申请日：2020-04-08

申请人： MERCK PATENT GMBH

发明人： Catherine Jorand-Lebrun ,  Roch Boivin ,  Theresa Johnson ,  Yanping Wang ,  Yufang Xiao ,  Xiaoling Chen ,  Nina Linde ,  Doreen Musch ,  Deepak Kumar

IPC分类号： C07D239/36 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052 ,  C07D491/107 ,  C07D491/20 ,  A61P35/00

摘要： The invention relates to pyrimidinone derivatives of the general Formula I, or a pharmaceutically acceptable salt thereof, and the use of the compounds of the present invention for the treatment of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.

公开(公告)号：US11702392B2

公开(公告)日：2023-07-18

申请号：US17181614

申请日：2021-02-22

申请人： MERCK PATENT GMBH

发明人： Catherine Jorand-Lebrun ,  Roch Boivin ,  Theresa Johnson ,  Yanping Wang ,  Yufang Xiao ,  Xiaoling Chen ,  Nina Linde ,  Doreen Musch ,  Deepak Kumar

IPC分类号： C07D239/36 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052 ,  C07D491/107 ,  C07D491/20 ,  A61P35/00

CPC分类号： C07D239/36 ,  A61P35/00 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/10 ,  C07D487/10 ,  C07D491/052 ,  C07D491/107 ,  C07D491/20

摘要： The invention relates to pyrimidinone derivatives of the general Formula I,




or a pharmaceutically acceptable salt thereof, and the use of the compounds of the present invention for the treatment of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.

公开(公告)号：US20200317622A1

公开(公告)日：2020-10-08

申请号：US16843735

申请日：2020-04-08

申请人： MERCK PATENT GMBH

发明人： Catherine Jorand-Lebrun ,  Roch Boivin ,  Theresa Johnson ,  Yanping Wang ,  Yufang Xiao ,  Xiaoling Chen ,  Nina Linde ,  Doreen Musch ,  Deepak Kumar

IPC分类号： C07D239/36 ,  A61P35/00 ,  C07D401/04 ,  C07D491/107 ,  C07D491/052 ,  C07D403/04 ,  C07D487/10 ,  C07D239/42 ,  C07D401/14 ,  C07D471/10 ,  C07D491/20

摘要： The invention relates to pyrimidinone derivatives of the general Formula I, or a pharmaceutically acceptable salt thereof, and the use of the compounds of the present invention for the treatment of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.