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公开(公告)号：US09775830B2
公开(公告)日：2017-10-03
申请号：US15342550
申请日：2016-11-03
申请人： Merck Patent GmbH
发明人： Henry Yu , Thomas E. Richardson , Robert James Foglesong , Lizbeth Celeste Deselm , Andreas Goutopoulos
IPC分类号： C07D231/12 , A61K31/423 , A61K31/427 , A61K31/415 , A61K31/4155 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06 , C07D413/06 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D231/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/10 , C07D417/10 , C07D471/04 , A61K9/00 , A61K47/06 , A61K9/06 , A61K9/19 , A61K9/20 , A61K9/48
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0078 , A61K9/06 , A61K9/19 , A61K9/2018 , A61K9/2059 , A61K9/48 , A61K31/4155 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K47/06 , C07D231/06 , C07D231/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D471/04
摘要： Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
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![Substituted pyrido[3,2-d]pyrimidines for treating cancer](/abs-image/US/2016/09/13/US09440968B2/abs.jpg.150x150.jpg)
公开(公告)号：US09440968B2
公开(公告)日：2016-09-13
申请号：US14432618
申请日：2013-11-27
申请人： Merck Patent GmbH
发明人： Bayard R. Huck , Ruoxi Lan , Justin Potnick , Lizbeth Celeste Deselm , Mark W. Cronin, Jr. , Constantin Neagu , Xiaoling Chen , Roch Boivin , Theresa L. Johnson , Andreas Goutopoulos
IPC分类号： A61K31/519 , C07D239/70 , C07D471/04 , C07D403/12 , C07D401/12 , C07D253/08 , A61K45/06 , A61K31/53
CPC分类号： C07D253/08 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
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公开(公告)号：US20210300940A1
公开(公告)日：2021-09-30
申请号：US17250489
申请日：2019-07-29
申请人： Merck Patent GmbH
发明人： Brian Sherer , Ruoxi Lan , Nadia Brugger , Xiaoling Chen , Momar Toure , Esther Cleary , Lizbeth Celeste Deselm , Yanping Wang
IPC分类号： C07D495/10 , C07D401/14 , C07D401/04 , C07D471/04 , C07D409/14 , C07D405/14 , C07D413/14 , C07D471/10 , C07D417/14
摘要： Compounds of Formula (I) and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists.
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公开(公告)号：US10030013B2
公开(公告)日：2018-07-24
申请号：US15701842
申请日：2017-09-12
申请人： Merck Patent GmbH
发明人： Catherine Jorand-Lebrun , Reinaldo Jones , Annie Cho Won , Ngan Nguyen , Theresa L. Johnson , Lizbeth Celeste Deselm , Kausik Panda
IPC分类号： A61K31/506 , C07D451/04 , C07D487/04 , C07D451/14 , C07D401/14 , C07D401/12 , C07D413/14 , C07D405/14 , C07D403/14 , C07D417/14
摘要： The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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![Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors](/abs-image/US/2018/05/29/US09981925B2/abs.jpg.150x150.jpg)
公开(公告)号：US09981925B2
公开(公告)日：2018-05-29
申请号：US15227638
申请日：2016-08-03
申请人： Merck Patent GmbH
发明人： Bayard R. Huck , Ruoxi Lan , Justin Potnick , Lizbeth Celeste Deselm , Mark W. Cronin, Jr. , Constantin Neagu , Xiaoling Chen , Roch Boivin , Theresa L. Johnson , Andreas Goutopoulos
IPC分类号： C07D253/08 , C07D403/12 , C07D401/12 , C07D471/04 , A61K45/06 , A61K31/519 , A61K31/53
CPC分类号： C07D253/08 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
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公开(公告)号：US09790221B2
公开(公告)日：2017-10-17
申请号：US14945610
申请日：2015-11-19
申请人： Merck Patent GmbH
发明人： Catherine Jorand-Lebrun , Reinaldo Jones , Annie Cho Won , Ngan Nguyen , Theresa L. Johnson , Lizbeth Celeste Deselm , Kausik Panda
IPC分类号： C07D451/04 , C07D401/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D401/14 , C07D451/14 , C07D487/04
CPC分类号： C07D451/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/14 , C07D487/04
摘要： The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
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公开(公告)号：US20150025066A1
公开(公告)日：2015-01-22
申请号：US14379625
申请日：2012-12-18
发明人： Henry Yu , Lizbeth Celeste Deselm
IPC分类号： C07D498/14 , C07D498/22 , A61K31/5383
CPC分类号： C07D498/14 , A61K31/5383 , C07D413/12 , C07D413/14 , C07D498/22 , Y02A50/409 , Y02A50/411
摘要： Compounds of the formula I in which A, L1, L2, X and Y have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
摘要翻译： 其中A，L1，L2，X和Y具有权利要求1所述含义的式I化合物是Syk的抑制剂，并且可以用于治疗类风湿性关节炎。
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公开(公告)号：US09517227B2
公开(公告)日：2016-12-13
申请号：US14300945
申请日：2014-06-10
申请人： Merck Patent GmbH
发明人： Henry Yu , Thomas E. Richardson , Robert James Foglesong , Lizbeth Celeste Deselm , Andreas Goutopoulos
IPC分类号： C07D231/06 , C07D405/06 , C07D403/06 , C07D401/06 , C07D417/10 , C07D413/06 , A61K31/4155 , A61K31/5377 , A61K31/415 , C07D231/12 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/06 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K45/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04 , A61K9/00 , A61K47/06 , A61K9/06 , A61K9/19 , A61K9/20 , A61K9/48
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0078 , A61K9/06 , A61K9/19 , A61K9/2018 , A61K9/2059 , A61K9/48 , A61K31/4155 , A61K31/423 , A61K31/427 , A61K31/437 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K47/06 , C07D231/06 , C07D231/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/04 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D471/04
摘要： Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
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公开(公告)号：US20150259339A1
公开(公告)日：2015-09-17
申请号：US14432618
申请日：2013-11-27
申请人： Merck Patent GmbH
发明人： Bayard R. Huck , Ruoxi Lan , Justin Potnick , Lizbeth Celeste Deselm , Mark W. Cronin, JR. , Constantin Neagu , Xiaoling Chen , Roch Boivin , Theresa L. Johnson , Andreas Goutopoulos
IPC分类号： C07D471/04 , A61K31/519 , C07D401/12 , C07D253/08 , A61K31/53
CPC分类号： C07D253/08 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Novel azaquinazoline carboxamide derivatives of formula (I) wherein W1, W2, W3, W4, R1, R2, R3 and m which are defined above, are p70S6K inhibitor, and can be employed, inter alia, for the treatment of hyperproliferative disorders.
摘要翻译： 式（I）的新型氮杂喹唑啉羧酰胺衍生物，其中上述定义的W1，W2，W3，W4，R1，R2，R3和m是p70S6K抑制剂，并且可以用于治疗过度增殖性疾病。
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公开(公告)号：US09073944B2
公开(公告)日：2015-07-07
申请号：US14379625
申请日：2012-12-18
申请人： Merck Patent GmbH
发明人： Henry Yu , Lizbeth Celeste Deselm
IPC分类号： C07D413/12 , C07D413/14 , C07D498/14 , A61K31/5383 , C07D498/22
CPC分类号： C07D498/14 , A61K31/5383 , C07D413/12 , C07D413/14 , C07D498/22 , Y02A50/409 , Y02A50/411
摘要： Compounds of the formula I in which A, L1, L2, X and Y have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
摘要翻译： 其中A，L1，L2，X和Y具有权利要求1所述含义的式I化合物是Syk的抑制剂，并且可以用于治疗类风湿性关节炎。
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