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公开(公告)号:US10927086B2
公开(公告)日:2021-02-23
申请号:US16483957
申请日:2018-02-19
申请人: Merck Sharp & Dohme Corp. , Kun Liu , Dane Clausen , Liangqin Guo , Yongxin Han , Shuwen He , Joseph Kozlowski , Derun Li , Qinglin Pu , Wensheng Yu , Hongjun Zhang
发明人: Kun Liu , Dane Clausen , Liangqin Guo , Yongxin Han , Shuwen He , Joseph Kozlowski , Derun Li , Qinglin Pu , Wensheng Yu , Hongjun Zhang
IPC分类号: C07D271/08 , C07D413/12
摘要: Compounds of Formula I, or a pharmaceutically acceptable salt, solvate or hydrate thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号:US11034661B2
公开(公告)日:2021-06-15
申请号:US16495883
申请日:2018-03-23
申请人: Merck Sharp & Dohme Corp. , Liangqin Guo , Yongxin Han , Kun Liu , Shuwen He , Joseph Kozlowski , Ravi Nargund , Wensheng Yu , Hongjun Zhang , Qinglin Pu , Derun Li , Abdelghani Achab , Guoqing Li
发明人: Liangqin Guo , Yongxin Han , Kun Liu , Shuwen He , Joseph Kozlowski , Ravi Nargund , Wensheng Yu , Hongjun Zhang , Qinglin Pu , Derun Li , Abdelghani Achab , Guoqing Li
IPC分类号: C07D271/08 , C07D413/12
摘要: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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3.
公开(公告)号:US20200277252A1
公开(公告)日:2020-09-03
申请号:US16753035
申请日:2018-10-04
申请人: Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou , MERCK SHARP & DOHME CORP.
发明人: Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
IPC分类号: C07C237/42 , C07D241/24 , C07D213/82 , C07D233/90 , C07D263/34 , C07D231/14 , C07D277/56 , C07D239/28 , C07D213/75 , C07D309/14 , C07D237/20 , C07D307/14 , C07D205/04 , C07D285/06 , C07D487/04
摘要: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号:US11319283B2
公开(公告)日:2022-05-03
申请号:US16753035
申请日:2018-10-04
申请人: MERCK SHARP & DOHME CORP. , Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
发明人: Meredeth Ann McGowan , Abdelghani Achab , Xavier Fradera , Yongxin Han , Derun Li , Jongwon Lim , Kun Liu , Nunzio Sciammetta , Catherine M. White , Wensheng Yu , Hongjun Zhang , Hua Zhou
IPC分类号: C07D205/04 , C07C237/42 , C07D213/75 , C07D213/82 , C07D231/14 , C07D233/90 , C07D237/20 , C07D239/28 , C07D241/24 , C07D263/34 , C07D277/56 , C07D285/06 , C07D307/14 , C07D309/14 , C07D487/04
摘要: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号:US09695198B2
公开(公告)日:2017-07-04
申请号:US14652150
申请日:2013-12-16
申请人: Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD.
发明人: Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka
IPC分类号: C07D413/14 , C07D417/06 , C07D498/04 , C07D513/04 , C07D413/12 , C07D471/04 , C07D413/06
CPC分类号: C07D513/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要: The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
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公开(公告)号:US20220056051A1
公开(公告)日:2022-02-24
申请号:US17312480
申请日:2019-12-13
申请人: Abdelghani Abe ACHAB , Matthew L. CHILDERS , Jared N. CUMMING , Symon GATHIAKA , Charles A. LESBURG , Derun LI , Min LU , Matthew J. MITCHELTREE , Anandan PALANI , Rachel L. PALTE , Hongjun ZHANG , Merck Sharp & Dohme Corp.
发明人: Abdelghani Abe Achab , Matthew L. Childers , Jared N. Cumming , Symon Gathiaka , Charles A. Lesburg , Derun Li , Min Lu , Matthew J. Mitcheltree , Anandan Palani , Rachel L. Palte , Hongjun Zhang
IPC分类号: C07F5/02
摘要: Described herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof. The compounds of Formula (I) act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.
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公开(公告)号:US20220259188A1
公开(公告)日:2022-08-18
申请号:US17614732
申请日:2020-06-01
申请人: Hua ZHOU , John J. ACTON, III , Michael J. ARDOLINO , Yi-Heng CHEN , Peter H. FULLER , Anmol GULATI , Rebecca Elizabeth JOHNSON , William P. KAPLAN , Solomon D. KATTAR , Mitchell H. KEYLOR , Derun LI , Kaitlyn Marie LOGAN , Min LU , Gregori J. MORRIELLO , Santhosh F. NEELAMKAVIL , Barbara PIO , Nunzio SCIAMMETTA , Vladimir SIMOV , Jing SU , Luis TORRES , Xin YAN , Merck Sharp & Dohme Corp.
发明人: Hua Zhou , John J. Acton, III , Michael J. Ardolino , Yi-Heng Chen , Peter H. Fuller , Anmol Gulati , Rebecca Elizabeth Johnson , William P. Kaplan , Solomon D. Kattar , Mitchell H. Keylor , Derun Li , Kaitlyn Marie Logan , Min Lu , Gregori J. Morriello , Santhosh F. Neelamkavil , Barbara Pio , Nunzio Sciammetta , Vladimir Simov , Jing Su , Luis Torres , Xin Yan
IPC分类号: C07D405/14 , C07D487/08 , C07D409/14 , C07D403/04 , C07D403/14 , C07D498/04 , C07D498/08 , C07D487/10 , C07D401/14 , C07D471/10 , C07D491/107 , C07D471/04 , C07D487/04 , A61P25/16
摘要: The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.
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公开(公告)号:US10414774B2
公开(公告)日:2019-09-17
申请号:US16324596
申请日:2017-08-10
申请人: Merck Sharp & Dohme Corp. , Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
发明人: Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
IPC分类号: C07D487/04 , C07D519/00 , A61P3/10 , C07D498/04 , C07D513/04 , C07D471/04
摘要: Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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9.
公开(公告)号:US20190218223A1
公开(公告)日:2019-07-18
申请号:US16324596
申请日:2017-08-10
申请人: Jared N. CUMMING , Kevin D. DYKSTRA , Alan HRUZA , Derun LI , Hong LIU , Haiqun TANG , Brandon M. TAOKA , Andreas VERRAS , Shawn P. WALSH , Wen-Lian WU , Merck Sharp & Dohme Corp.
发明人: Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
IPC分类号: C07D487/04 , C07D519/00 , C07D471/04 , C07D498/04 , C07D513/04 , A61P3/10
CPC分类号: C07D487/04 , A61P3/10 , C07D471/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要: Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.
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公开(公告)号:US20150368269A1
公开(公告)日:2015-12-24
申请号:US14652150
申请日:2013-12-16
申请人: Tomokazu HIRABAYASHI , Mika KATSUNO , Cameron James SMITH , Edward SHERER , Louis-Charles CAMPEAU , James BALKOVEC , William John GREENLEE , Derun LI , Liangqin GUO , Tin Yan CHAN , Yi-Heng CHEN , Yili CHEN , Samuel CHACKALAMANNIL , John Qiang TAN , MERCH SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD.
发明人: Cameron James Smith , Edward Sherer , Louis-Charles Campeau , James Balkovec , William John Greenlee , Derun Li , Liangqin Guo , Tin-Yau Chan , Yi-Heng Chen , Yili Chen , Samuel Chackalamannil , John Qiang Tan , Tomokazu Hirabayashi , Mika Sekioka
IPC分类号: C07D513/04 , C07D417/06 , C07D413/06 , C07D498/04 , C07D471/04
CPC分类号: C07D513/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要: The present invention provides a compound of Formula (I) where A is a heterocycle ring system and B is a heterocycle ring system or aryl ring system, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译: 本发明提供式(I)化合物,其中A为杂环环系,B为杂环环系或芳环系,以及包含一种或多种所述化合物的药物组合物,以及使用所述化合物治疗或预防的方法 血栓形成,栓塞,高凝状态或纤维化变化。
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