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公开(公告)号：US09745295B2
公开(公告)日：2017-08-29
申请号：US14786464
申请日：2014-04-22
发明人： Neville J. Anthony , Brian M. Andresen , Alan B. Northrup , Kaleen K. Childers , Anthony Donofrio , Thomas A. Miller , Yuan Liu , Michelle R. Machacek , Hyun Chong Woo , Kerrie B. Spencer , John Michael Ellis , Michael D. Altman , Eric T. Romeo , Daniel Guay , Jonathan Grimm , Marie-Eve Lebrun , Joel S. Robichaud , Liping Wang , Byron DuBois , Qiaolin Deng
IPC分类号： A61K31/4439 , A61K31/53 , A61K31/501 , A61K31/497 , A61K31/506 , C07D417/12 , C07D417/14
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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公开(公告)号：US10246457B2
公开(公告)日：2019-04-02
申请号：US15564352
申请日：2016-04-04
发明人： Tony Siu , Michael D. Altman , Brian M. Andresen , Jian Liu , Joseph Kozlowski , Sobhana Babu Boga , Younong Yu , Rajan Anand , Jiaqiang Cai , Dahai Wang , Shilan Liu
IPC分类号： C07D471/04 , C07D401/14 , C07D405/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/14 , C07D409/14 , A61P19/02 , A61K45/06 , C07D231/56 , C07D413/14
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R7, R8 and R9 are as herein described. The present invention also provides pharmaceutical compositions comprising these compounds and methods for their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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公开(公告)号：US09809561B2
公开(公告)日：2017-11-07
申请号：US15103414
申请日：2014-12-19
发明人： Thomas D. Aicher , Chad A. VanHuis , William D. Thomas , John K. MacLean , Brian M. Andresen , Kenneth J. Barr , Corey E. Bienstock , Neville J. Anthony , Matthew Daniels , Kun Liu , Yuan Liu , Catherine M. White , Blair T. Lapointe , Nunzio Sciammetta , Vladimir Simov
IPC分类号： C07D265/36 , C07D413/14 , C07D215/58 , C07D401/06 , C07D401/12 , C07D413/04 , C07D471/04 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/538 , A61K45/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07D487/04
CPC分类号： C07D265/36 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/538 , A61K45/06 , C07D215/58 , C07D401/06 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04
摘要： The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2, R3, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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4.发明申请CARBAMATE BENZOXAZINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE 有权用于调节罗丹明活性和疾病治疗的碳酸酯苯并咪唑酸和酸衍生物公开(公告)号：US20160311787A1
公开(公告)日：2016-10-27
申请号：US15103409
申请日：2014-12-19
发明人： Thomas D. Aicher , Chad A. VanHuis , John MacLean , Brian M. Andresen , Kenneth J. Barr , Corey Bienstock , Matthew Daniels , Kun Liu , Yuan Liu , Catherine White , Nunzio Sciammetta , Vladimir Simov
IPC分类号： C07D265/36 , C07D413/12 , C07D417/12 , C07D471/04 , C07D513/04 , A61K31/538 , C07D487/04
CPC分类号： C07D265/36 , A61K31/538 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, Ra1, Ra2, Rb1, Rb2, Rc, Rd, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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公开(公告)号：US09943516B2
公开(公告)日：2018-04-17
申请号：US15515388
申请日：2015-09-25
发明人： Michael D. Altman , Brian M. Andresen , Jason D. Brubaker , Anthony Donofrio , Thierry Fischmann , Craig R. Gibeau , Charles A. Lesburg , Jongwon Lim , John K. F. Maclean , Umar F. Mansoor , Alan B. Northrup , John M. Sanders , Graham F. Smith , Luis Torres
IPC分类号： A61K31/517 , C07D405/04 , A61K45/06 , C07D239/94
CPC分类号： A61K31/517 , A61K45/06 , A61P29/00 , A61P35/00 , C07D239/94 , C07D405/04 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
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6.发明授权3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof 有权3-环己烯基和环己基取代的吲哚和吲唑化合物作为RORGAMAMT抑制剂及其用途公开(公告)号：US09487490B2
公开(公告)日：2016-11-08
申请号：US14421057
申请日：2013-08-14
发明人： Kenneth J. Barr , John K. Maclean , Hongjun Zhang , Richard T. Beresis , Dongshan Zhang , Brian M. Andresen , Neville J. Anthony , Blair T. Lapointe , Nunzio Sciammetta
IPC分类号： C07D471/04 , A61K31/4745 , C07D231/56 , A61K31/404 , A61K31/416 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D209/26 , C07D401/06 , C07D403/06 , C07D405/12 , C07D413/06
CPC分类号： C07D231/56 , A61K31/404 , A61K31/416 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D209/26 , C07D401/06 , C07D403/06 , C07D405/12 , C07D413/06 , C07D471/04 , Y02A50/409
摘要： The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
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7.发明申请公开(公告)号：US20150284381A1
公开(公告)日：2015-10-08
申请号：US14440520
申请日：2013-11-04
IPC分类号： C07D417/14 , A61K31/444
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/008 , A61K9/08 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K31/444 , A61K45/06 , A61K47/10 , A61K47/186 , A61K47/24 , A61K47/26 , A61K47/38 , A61K2300/00
摘要： The invention provides certain amino-pyridine-containing compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R3, R4, R5, R6, and the subscript n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译： 本发明提供某些含有氨基 - 吡啶的式（I）（I）化合物或其药学上可接受的盐，其中R3，R4，R5，R6和下标n如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。
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公开(公告)号：US20190292159A1
公开(公告)日：2019-09-26
申请号：US16270882
申请日：2019-02-08
发明人： Thomas D. Aicher , Chad A. VanHuis , William D. Thomas , John K. MacLean , Brian M. Andresen , Kenneth J. Barr , Corey E. Bienstock , Neville J. Anthony , Matthew Daniels , Kun Liu , Yuan Liu , Catherine M. White , Blair T. Lapointe , Nunzio Sciammetta , Vladimir Simov
IPC分类号： C07D265/36 , C07D413/12 , A61K31/4709 , C07D413/06 , C07D487/04 , C07D417/06 , C07D471/04 , C07D413/04 , C07D401/12 , C07D401/06 , C07D215/58 , C07D413/14 , A61K45/06 , A61K31/538 , A61K31/4375 , A61K31/47
摘要： The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2, R3, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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公开(公告)号：US10221146B2
公开(公告)日：2019-03-05
申请号：US15730997
申请日：2017-10-12
发明人： Thomas D. Aicher , Chad A. VanHuis , William D. Thomas , John K. MacLean , Brian M. Andresen , Kenneth J. Barr , Corey E. Bienstock , Neville J. Anthony , Matthew Daniels , Kun Liu , Yuan Liu , Catherine M. White , Blair T. Lapointe , Nunzio Sciammetta , Vladimir Simov
IPC分类号： C07D265/36 , C07D413/14 , C07D215/58 , C07D401/06 , C07D401/12 , C07D413/04 , C07D471/04 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/538 , A61K45/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07D487/04
摘要： The invention provides certain bicyclic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2, R3, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
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公开(公告)号：US09822107B2
公开(公告)日：2017-11-21
申请号：US15105713
申请日：2014-12-18
申请人： Brian M. Andresen , Kenneth L. Arrington , Ryan D. Otte , John Michael Ellis , John W. Butcher , Alan B. Northrup , Joel S. Robichaud , Jacques Yves Gauthier , Jean-Francois Fournier , MERCK SHARP & DOHME CORP.
发明人： Brian M. Andresen , Kenneth L. Arrington , Ryan D. Otte , John Michael Ellis , John W. Butcher , Alan B. Northrup , Joel S. Robichaud , Jacques Yves Gauthier , Jean-Francois Fournier
IPC分类号： C07D417/12 , C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/538
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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