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公开(公告)号：US20220331321A1
公开(公告)日：2022-10-20
申请号：US17633655
申请日：2020-07-21
申请人： Merck Sharp & Dohme Corp. , The Walter and Eliza Hall Institute of Medical Research , MSD R & D (China) Co. LTD.
发明人： John A. McCauley , Alan F. Cowman , Manuel de Lera Ruiz , Paola Favuzza , Zhuyan Guo , Bin Hu , Michael J. Kelly, III , Zhiyu Lei , David B. Olsen , Brad Sleebs , Jennifer K. Thompson , Tony Triglia , Dongmei Zhan , Cailing Zhang , Lianyun Zhao
IPC分类号： A61K31/513 , C07D405/14 , C07D493/10 , C07D491/052 , C07D409/14 , C07D239/22 , C07D405/12 , C07D409/04 , A61P33/06 , A61K45/06
摘要： Methods of treating malaria comprising administration of compounds of Formula (I′) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
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公开(公告)号：US20230139282A1
公开(公告)日：2023-05-04
申请号：US17795349
申请日：2021-02-02
申请人： Manuel DE LERA RUIZ , Paola FAVUZZA , Zhuyan GUO , Bin HU , Michael J. KELLY, III , Zhiyu LEI , John A. MCCAULEY , David B. OLSEN , Brad SLEEBS , Tony TRIGLIA , Dongmei ZHAN , Lianyun ZHAO , Merck Sharp & Dohme LLC , The Walter and Eliza Hall Institute of Medical Research , MSD R&D (China) Co., Ltd.
发明人： Manuel de Lera Ruiz , Paola Favuzza , Zhuyan Guo , Bin Hu , Michael J. Kelly, III , Zhiyu Lei , John A. McCauley , David B. Olsen , Brad Sleebs , Tony Triglia , Dongmei Zhan , Lianyun Zhao
IPC分类号： A61K31/513 , A61K45/06 , C07D405/12 , C07D233/88 , C07D405/14 , C07D417/14 , C07D491/18 , A61P33/06 , A61K31/529 , A61K31/5377 , C07D401/06
摘要： Provided are methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. Also provided are uses of the compounds of Formula (I), as defined herein, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
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公开(公告)号：US20230013692A1
公开(公告)日：2023-01-19
申请号：US17776040
申请日：2020-11-16
申请人： Merck Sharp & Dohme LLC , MSD R&D (China) Co. Ltd. , The Walter and Eliza Hall Institute of Medical Research
发明人： John A. McCauley , Manuel de Lera Ruiz , Zhuyan Guo , Bin Hu , Michael J. Kelly, III , Zhiyu Lei , David B. Olsen , Brad Sleebs , Dongmei Zhan , Lianyun Zhao
IPC分类号： C07D239/22 , C07D401/06 , C07D405/14 , A61P33/06
摘要： The present invention provides methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for the possible inhibition of plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
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公开(公告)号：US20210379020A1
公开(公告)日：2021-12-09
申请号：US17399589
申请日：2021-08-11
发明人： Tanweer A. Khan , Jared N. Cumming , David B. Olsen , Justin A. Boddey , Alan F. Cowman , Brad E. Sleebs
IPC分类号： A61K31/4168 , A61K31/4439 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/454 , A61K31/496 , A61K31/4985 , A61K31/495 , A61K31/5395 , B32B27/00 , B32B27/18 , B41J2/005 , B41M5/025 , B44C1/17 , A61P33/06 , A61K31/5377 , A61K45/06
摘要： The present invention provides methods of treating malaria by administration of a compound of Formula (I): or a pharmaceutically acceptable salt of said compound, to a subject in need thereof, wherein the variables X, R1, R3, R4, R5, A, B, L, m and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
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公开(公告)号：US20200223220A1
公开(公告)日：2020-07-16
申请号：US16827776
申请日：2020-03-24
发明人： Tanweer A. Khan , Jared N. Cumming , David B. Olsen , Justin A. Boddey , Alan F. Cowman , Brad E. Sleebs
摘要： The present invention provides methods of treating malaria by administration of a compound of Formula (I): or a pharmaceutically acceptable salt of said compound, to a subject in need thereof, wherein the variables X, R1, R3, R4, R5, A, B, L, m and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
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公开(公告)号：US20190046507A1
公开(公告)日：2019-02-14
申请号：US16076462
申请日：2017-02-13
发明人： Tanweer A. Khan , Jared N. Cumming , David B. Olsen , Justin A. Boddey , Alan F. Cowman , Brad E. Sleebs
IPC分类号： A61K31/4168 , A61K31/496 , A61K31/4985 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/4178 , A61K31/422 , A61K31/5377 , A61K45/06 , A61P33/06
摘要： The present invention provides methods of treating malaria by administration of a compound of Formula (I): or a pharmaceutically acceptable salt of said compound, to a subject in need thereof, wherein the variables X, R1, R3, R4, R5, A, B, L, m and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
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公开(公告)号：US20200230140A1
公开(公告)日：2020-07-23
申请号：US16076400
申请日：2017-02-13
发明人： Tanweer A. Khan , Jared N. Cumming , David B. Olsen , Justin A. Boddey , Alan F. Cowman , Brad E. Sleebs
IPC分类号： A61K31/513 , A61K31/527 , A61P33/06
摘要： The present invention provides methods of treating malaria comprising administration of an N3-substituted iminopyrimidinone of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables R1, R2, R3, R4, R5, A, B, L, m, and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.
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公开(公告)号：US20210061777A1
公开(公告)日：2021-03-04
申请号：US17093833
申请日：2020-11-10
发明人： Mihir B. Mandal , David B. Olsen , Jing Su , Lihu Yang , Katherine Young , Takao Suzuki , Lanying You
IPC分类号： C07D263/20 , C07D413/14 , A61K31/421 , A61K31/422 , C07D413/10 , A61K45/06 , A61K31/427 , A61K31/4439 , A61K31/541 , C07D413/06 , C07D417/10 , C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/553 , C07D413/04 , C07D417/14
摘要： The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
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公开(公告)号：US09777035B2
公开(公告)日：2017-10-03
申请号：US14669398
申请日：2015-03-26
IPC分类号： A61K31/7064 , A61K45/06 , C07H19/12 , C07H19/14 , C07H19/06 , C07D487/04
CPC分类号： C07H19/14 , A61K31/7064 , A61K45/06 , C07D487/04 , C07H19/06 , C07H19/12
摘要： The present invention is directed to 4′-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
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公开(公告)号：US09765107B2
公开(公告)日：2017-09-19
申请号：US14899008
申请日：2014-06-16
发明人： Stephane Bogen , Vinay Girijavallabhan , Quang Truong , Ping Chen , Frank Bennett , Angela Kerekes , Qun Dang , David B. Olsen , Ian Davies
IPC分类号： A01N43/04 , A61K31/70 , C07H19/10 , A61K45/06 , A61K31/661 , C07F9/6558 , C07F9/6574 , C07H19/11 , A61K31/7072 , A61K31/7068 , A61K31/706 , A61K31/7064
CPC分类号： C07H19/10 , A61K31/661 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07F9/65586 , C07F9/65744 , C07H19/11 , A61K2300/00
摘要： The present invention relates to Cyclic Phosphonate Substituted Nucleoside Derivatives of Formula (I): (structure) and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein, as well as to compositions and methods of using the Cyclic Phosphonate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
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