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1.发明授权Cosmetic composition for skin cell regeneration mimicking extracellular matrix 有权用于皮肤细胞再生的化妆品组合模仿细胞外基质公开(公告)号：US08895515B2
公开(公告)日：2014-11-25
申请号：US12955301
申请日：2010-11-29
申请人： Mi Jin Kim , Jong Won Shim , Yong Jin Kim , Eun Jung An , Chan Woo Lee , Soo Jin Lee , Jin Woong Kim
发明人： Mi Jin Kim , Jong Won Shim , Yong Jin Kim , Eun Jung An , Chan Woo Lee , Soo Jin Lee , Jin Woong Kim
摘要： The present invention relates to a cosmetic composition which mimics the extracellular matrix to stimulate the regeneration of skin cells, and more particularly to a cosmetic composition which contains active ingredients consisting of low-molecular-weight materials, which easily permeate through the skin, at a composition ratio similar to that in the extracellular matrix. The cosmetic composition stimulates the repair of the skin to maintain homeostasis and is effective for the regeneration of skin cells.
摘要翻译： 本发明涉及一种化妆品组合物，其模拟细胞外基质以刺激皮肤细胞的再生，更具体地涉及一种化妆品组合物，其含有由容易渗透皮肤的低分子量材料组成的活性成分 组成比与细胞外基质相似。 化妆品组合物刺激皮肤的修复以维持体内平衡，并且对皮肤细胞的再生是有效的。
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2.发明申请COSMETIC COMPOSITION FOR SKIN CELL REGENERATION MIMICKING EXTRACELLULAR MATRIX 有权化妆品组合物用于皮肤细胞再生复合细胞基质公开(公告)号：US20110130339A1
公开(公告)日：2011-06-02
申请号：US12955301
申请日：2010-11-29
申请人： Mi Jin KIM , Jong Won Shim , Yong Jin Kim , Eun Jung An , Chan Woo Lee , Soo Jin Lee , Jin Woong Kim
发明人： Mi Jin KIM , Jong Won Shim , Yong Jin Kim , Eun Jung An , Chan Woo Lee , Soo Jin Lee , Jin Woong Kim
摘要： The present invention relates to a cosmetic composition which mimics the extracellular matrix to stimulate the regeneration of skin cells, and more particularly to a cosmetic composition which contains active ingredients consisting of low-molecular-weight materials, which easily permeate through the skin, at a composition ratio similar to that in the extracellular matrix. The cosmetic composition stimulates the repair of the skin to maintain homeostasis and is effective for the regeneration of skin cells.
摘要翻译： 本发明涉及一种化妆品组合物，其模拟细胞外基质以刺激皮肤细胞的再生，更具体地涉及一种化妆品组合物，其含有由容易渗透皮肤的低分子量材料组成的活性成分 组成比与细胞外基质相似。 化妆品组合物刺激皮肤的修复以维持体内平衡，并且对皮肤细胞的再生是有效的。
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3.发明授权Multi-layered lamellar granule and skin external application composition containing same 有权多层片状颗粒和含有它的皮肤外用组合物公开(公告)号：US08771743B2
公开(公告)日：2014-07-08
申请号：US13055091
申请日：2008-09-02
申请人： Do Hoon Kim , Eun Jung An , Jae Sung Hwang , Hong Ju Shin , Won Seok Park , Chang Geun Yi , Jong Hee Park , Jeong Hwan Kim , Jin Woong Kim , Jung A Seo , Yong Jin Kim , Jong Won Shim , Mi Jin Kim
发明人： Do Hoon Kim , Eun Jung An , Jae Sung Hwang , Hong Ju Shin , Won Seok Park , Chang Geun Yi , Jong Hee Park , Jeong Hwan Kim , Jin Woong Kim , Jung A Seo , Yong Jin Kim , Jong Won Shim , Mi Jin Kim
CPC分类号： A61K9/5078 , A61K8/0245 , A61K8/68 , A61K9/0014 , A61K9/10 , A61K2800/412 , A61K2800/614 , A61Q19/007
摘要： Provided are: a multi-layered lamellar granule comprising a nucleating agent, a ceramide-containing artificial stratum corneum lipid lamellar layer which encases the nucleating agent and a polymer layer disposed on the artificial stratum corneum lipid lamellar layer; and an external skin application composition comprising the same. The external skin application composition shows improved moisturizing and barrier repair capabilities when applied to the skin, which can be advantageously used in cosmetics and pharmaceuticals.
摘要翻译： 提供：包含成核剂，包含成核剂的含神经酰胺的人造角质层脂质层层和设置在人造角质层脂层上的聚合物层的多层片状颗粒; 和包含其的外用皮肤应用组合物。 外用皮肤应用组合物在施用于皮肤时显示改善的保湿和屏障修复能力，其可有利地用于化妆品和药物中。
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4.发明申请公开(公告)号：US20110123583A1
公开(公告)日：2011-05-26
申请号：US13055091
申请日：2008-09-02
申请人： Do Hoon Kim , Eun Jung An , Jae Sung Hwang , Hong Ju Shin , Won Seok Park , Chang Guen Yi , Jong Hee Park , Jeong Hwan Kim , Jin Woong Kim , Jung A Seo , Yong Jin Kim , Jong Won Shim , Mi Jin Kim
发明人： Do Hoon Kim , Eun Jung An , Jae Sung Hwang , Hong Ju Shin , Won Seok Park , Chang Guen Yi , Jong Hee Park , Jeong Hwan Kim , Jin Woong Kim , Jung A Seo , Yong Jin Kim , Jong Won Shim , Mi Jin Kim
IPC分类号： A61K8/11 , A61K31/197 , A61K31/575 , A61Q19/00
CPC分类号： A61K9/5078 , A61K8/0245 , A61K8/68 , A61K9/0014 , A61K9/10 , A61K2800/412 , A61K2800/614 , A61Q19/007
摘要： Provided are: a multi-layered lamellar granule comprising a nucleating agent, a ceramide-containing artificial stratum corneum lipid lamellar layer which encases the nucleating agent and a polymer layer disposed on the artificial stratum corneum lipid lamellar layer; and an external skin application composition comprising the same. The external skin application composition shows improved moisturizing and barrier repair capabilities when applied to the skin, which can be advantageously used in cosmetics and pharmaceuticals.
摘要翻译： 提供：包含成核剂，包含成核剂的含神经酰胺的人造角质层脂质层层和设置在人造角质层脂层上的聚合物层的多层片状颗粒; 和包含其的外用皮肤应用组合物。 外用皮肤应用组合物在施用于皮肤时显示改善的保湿和屏障修复能力，其可有利地用于化妆品和药物中。
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5.发明申请Cationic Polymer Nanoparticles Encapsulating An Active Ingredients, And The Cosmetic Composition Containing The Same 有权封装活性成分的阳离子聚合物纳米颗粒，以及含有它的化妆品组合物公开(公告)号：US20080268035A1
公开(公告)日：2008-10-30
申请号：US12090680
申请日：2006-10-18
申请人： Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
发明人： Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
IPC分类号： A61K9/51 , A61K31/122 , A61K8/72
CPC分类号： A61K8/11 , A61K8/671 , A61K8/8152 , A61K8/85 , A61K2800/413 , A61K2800/5426 , A61Q19/00 , C08F220/18 , C08F220/34 , C08G63/6852 , C08F2220/1825
摘要： Disclosed herein are cationic polymer nanocapsules encapsulating an oil-soluble active ingredient, and a cosmetic composition containing the same. The cationic polymer nanocapsules have a molecular weight of 5,000-100,000, a surface potential of 5-100 mV and a particle size of 50-500 nm. Also, disclosed is a cosmetic composition containing said cationic polymer nanocapsules.
摘要翻译： 本文公开了包封油溶性活性成分的阳离子聚合物纳米胶囊和含有它们的化妆品组合物。 阳离子聚合物纳米胶囊的分子量为5,000-100,000，表面电位为5-100mV，粒度为50-500nm。 还公开了含有所述阳离子聚合物纳米胶囊的化妆品组合物。
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6.发明授权Cationic polymer nanoparticles encapsulating an active ingredients, and the cosmetic composition containing the same 有权包封活性成分的阳离子聚合物纳米颗粒和含有它的化妆品组合物公开(公告)号：US08877217B2
公开(公告)日：2014-11-04
申请号：US12090680
申请日：2006-10-18
申请人： Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
发明人： Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
IPC分类号： A61K8/11
CPC分类号： A61K8/11 , A61K8/671 , A61K8/8152 , A61K8/85 , A61K2800/413 , A61K2800/5426 , A61Q19/00 , C08F220/18 , C08F220/34 , C08G63/6852 , C08F2220/1825
摘要： Disclosed herein are cationic polymer nanocapsules encapsulating an oil-soluble active ingredient, and a cosmetic composition containing the same. The cationic polymer nanocapsules have a molecular weight of 5,000-100,000, a surface potential of 5-100 mV and a particle size of 50-500 nm. Also, disclosed is a cosmetic composition containing said cationic polymer nanocapsules.
摘要翻译： 本文公开了包封油溶性活性成分的阳离子聚合物纳米胶囊和含有它们的化妆品组合物。 阳离子聚合物纳米胶囊的分子量为5,000-100,000，表面电位为5-100mV，粒度为50-500nm。 还公开了含有所述阳离子聚合物纳米胶囊的化妆品组合物。
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公开(公告)号：US09849089B2
公开(公告)日：2017-12-26
申请号：US13878735
申请日：2011-10-12
申请人： Eun Jung An , Do Hoon Kim , Hyung Jun Lim , Jong Won Shim , Choon Bok Jeong , Lee Kyoung Kwon , Jun Oh Kim
发明人： Eun Jung An , Do Hoon Kim , Hyung Jun Lim , Jong Won Shim , Choon Bok Jeong , Lee Kyoung Kwon , Jun Oh Kim
CPC分类号： A61K9/14 , A61K8/0241 , A61K8/042 , A61K8/14 , A61K8/553 , A61K8/735 , A61K2800/10 , A61K2800/622 , A61K2800/654 , A61Q19/00
摘要： The present invention relates to hydrogel particles coated with lipid, which are made from dispersing hydrogel particles in an organic solvent in which lipids are dissolved, and to a method for manufacturing same. Unlike the existing method for manufacturing hydrogel core vesicles, the present invention can effectively manufacture same by using an emulsification method, without involving the steps of chemical treatment of the surface of hydrogels or dilution, thereby facilitating mass production and preventing the decrease of drug encapsulation efficiency. The present method could be widely used for research on delivery carriers of oil/water-soluble active material or cell structure reproduction and more particularly, a keratinocyte mimetic of the present invention containing natural moisturizing factors can contain a large quantity of bound water for a long time, thereby exhibiting superior capability to retain moisture and moisturize, and providing a composition for an ingredient in cosmetics for moisturizing.
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公开(公告)号：US20130202667A1
公开(公告)日：2013-08-08
申请号：US13878735
申请日：2011-10-12
申请人： Eun Jung An , Do Hoon Kim , Hyung Jun Lim , Jong Won Shim , Choon Bok Jeong , Lee Kyoung Kwon , Jun Oh Kim
发明人： Eun Jung An , Do Hoon Kim , Hyung Jun Lim , Jong Won Shim , Choon Bok Jeong , Lee Kyoung Kwon , Jun Oh Kim
CPC分类号： A61K9/14 , A61K8/0241 , A61K8/042 , A61K8/14 , A61K8/553 , A61K8/735 , A61K2800/10 , A61K2800/622 , A61K2800/654 , A61Q19/00
摘要： The present invention relates to hydrogel particles coated with lipid, which are made from dispersing hydrogel particles in an organic solvent in which lipids are dissolved, and to a method for manufacturing same. Unlike the existing method for manufacturing hydrogel core vesicles, the present invention can effectively manufacture same by using an emulsification method, without involving the steps of chemical treatment of the surface of hydrogels or dilution, thereby facilitating mass production and preventing the decrease of drug encapsulation efficiency. The present method could be widely used for research on delivery carriers of oil/water-soluble active material or cell structure reproduction and more particularly, a keratinocyte mimetic of the present invention containing natural moisturizing factors can contain a large quantity of bound water for a long time, thereby exhibiting superior capability to retain moisture and moisturize, and providing a composition for an ingredient in cosmetics for moisturizing.
摘要翻译： 本发明涉及通过将水凝胶颗粒分散在其中溶解有脂质的有机溶剂中制成的脂质的水凝胶颗粒及其制造方法。 与现有的水凝胶核心泡囊的制造方法不同，本发明可以通过乳化法有效地制造，但不涉及化学处理水凝胶表面或稀释的步骤，从而促进大量生产并防止药物包封效率的降低 。 本发明的方法可广泛用于油/水溶性活性物质或细胞结构繁殖的递送载体的研究，更具体地说，含有天然保湿因子的本发明的角质形成细胞模拟物可以含有长时间的大量结合水 从而表现出优异的保持水分和保湿的能力，并提供用于保湿的化妆品中的成分的组合物。
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9.发明授权UV-scattering inorganic/polymer composite particles and a method for preparing the same 有权紫外线散射无机/聚合物复合颗粒及其制备方法公开(公告)号：US07247378B2
公开(公告)日：2007-07-24
申请号：US10157987
申请日：2002-05-31
申请人： Jin Woong Kim , Jong Won Shim , Young Ha Lee , Han Kon Kim , Hak Hee Kang
发明人： Jin Woong Kim , Jong Won Shim , Young Ha Lee , Han Kon Kim , Hak Hee Kang
CPC分类号： C08L51/10 , C08F257/02 , C08F265/04 , C08F292/00 , C08L51/003 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： There are provided inorganic/polymer composite particles having good UV-scattering efficiency and improved dispersion stability in organic formulation; and a method for preparing the same, which comprises the following steps of (1) dispersing hydrophobic-treated inorganic particles in monomer and then adding initiator thereto; (2) emulsifying the inorganic dispersion of step (1) in presence of surfactant and dispersion stabilizer; and (3) suspension polymerizing the inorganic/monomer emulsion of step (2), to give inorganic/polymer composite particles.
摘要翻译： 提供了具有良好的UV散射效率和改善有机配方中分散稳定性的无机/聚合物复合颗粒; 及其制备方法，其包括以下步骤：（1）将疏水处理的无机颗粒分散在单体中，然后向其中加入引发剂; （2）在表面活性剂和分散稳定剂的存在下乳化步骤（1）的无机分散体; 和（3）将步骤（2）的无机/单体乳液悬浮聚合，得到无机/聚合物复合颗粒。
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