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公开(公告)号：US09440079B2
公开(公告)日：2016-09-13
申请号：US13470328
申请日：2012-05-13
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.
摘要翻译： 用于管理刺激安全限值的神经刺激系统。 系统确定每个电极处的组织电荷注入度量，将该度量与硬停止电荷限制进行比较，并且根据比较来防止神经刺激器将刺激能量递送至组织区域。 硬停止极限可以是用户可编程的，或者可以响应于电极特性的检测而被自动修改。 该系统可以定量地向使用者通知注入到组织中的注入电荷的值。 电极可以组织成不同的组，在这种情况下，系统可以在每个电极组中独立地直接控制组织电荷。 如果提供电流转向，则系统可以沿着一个方向沿着组织区域移位电刺激能量，同时防止每个电极处的电荷注入值达到或超过硬停止充电极限。
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公开(公告)号：US09950172B2
公开(公告)日：2018-04-24
申请号：US13470326
申请日：2012-05-13
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.
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公开(公告)号：US07742810B2
公开(公告)日：2010-06-22
申请号：US11752895
申请日：2007-05-23
IPC分类号： A61N1/05
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is placed in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译： 提供了向患者提供治疗的方法和神经刺激系统。 将至少一个电极放置成与患者的组织接触。 从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激 脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。 调节预脉冲具有相对短的持续时间（例如，小于200μs）。
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公开(公告)号：US08473061B2
公开(公告)日：2013-06-25
申请号：US12761622
申请日：2010-04-16
申请人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K. L. Peterson , Courtney Lane , Anne Margaret Pianca
发明人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K. L. Peterson , Courtney Lane , Anne Margaret Pianca
IPC分类号： A61N1/00
CPC分类号： A61N1/0534 , A61N1/20 , A61N1/3606 , A61N1/36082 , A61N1/36182
摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.
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公开(公告)号：US08311644B2
公开(公告)日：2012-11-13
申请号：US12782589
申请日：2010-05-18
IPC分类号： A61N1/05
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译： 提供了向患者提供治疗的方法和神经刺激系统。 至少一个电极与患者的组织接触放置。 从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激 脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。 调节预脉冲具有相对短的持续时间（例如，小于200μs）。
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6.发明授权公开(公告)号：US09446249B2
公开(公告)日：2016-09-20
申请号：US13244458
申请日：2011-09-24
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36185 , A61N1/372
摘要： A system and method for locating an implantable tissue stimulation lead within a patient. A measurement indicative of a coupling efficiency between the tissue stimulation lead and tissue at a location is taken. The location of the tissue stimulation lead relative to the tissue is tracked. Coupling efficiency information based on the measurement from the monitoring device is generated, tracking information based on the tissue stimulation lead location is generated, and the coupling efficiency information and tracking information is concurrently conveyed to the user.
摘要翻译： 一种用于定位患者内的可植入组织刺激引线的系统和方法。 采用指示组织刺激引线和组织在一处的耦合效率的测量。 跟踪组织刺激引线相对于组织的位置。 生成基于来自监视装置的测量的耦合效率信息，生成基于组织刺激引导位置的跟踪信息，并且耦合效率信息和跟踪信息被同时传送给用户。
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公开(公告)号：US08918174B2
公开(公告)日：2014-12-23
申请号：US11625281
申请日：2007-01-19
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/36185 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37252 , A61N1/3787
摘要： An implantable medical device system, external programmer, and method of indicating the status of a power source in a medical device implanted within a patient. An actual status of the power source is maintained at the medical device. A status indicator of an external programmer indicates an estimated status of the power source, which can be reconciled with the actual status of the power source when the external programmer is placed in telecommunicative contact with the implantable medical device.
摘要翻译： 一种植入式医疗装置系统，外部编程器和指示植入患者体内的医疗装置中的电源的状态的方法。 在医疗设备上保持电源的实际状态。 外部编程器的状态指示器指示当外部编程器与可植入医疗设备进行电话接触时可以与电源的实际状态对准的电源的估计状态。
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8.发明授权System and method for displaying stimulation field generated by electrode array 有权用于显示由电极阵列产生的刺激场的系统和方法公开(公告)号：US08805524B2
公开(公告)日：2014-08-12
申请号：US13361669
申请日：2012-01-30
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译： 可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复 这样的比率。 所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。 随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。 刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。 这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。
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9.发明授权Current generation architecture for an implantable stimulator device having coarse and fine current control 有权具有粗细和精细电流控制的植入式刺激器装置的当前一代架构公开(公告)号：US08620436B2
公开(公告)日：2013-12-31
申请号：US11550763
申请日：2006-10-18
IPC分类号： A61N1/02
CPC分类号： A61N1/36125 , A61N1/0531 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/36071
摘要： Disclosed herein is a current generation architecture for an implantable stimulator device such as an Implantable Pulse Generator (IPG). Current source and sink circuitry are both divided into coarse and fine portions, which respectively can provide a coarse and fine current resolution to a specified electrode on the IPG. The coarse portion is distributed across all of the electrodes and so can source or sink current to any of the electrodes. The coarse portion is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking a coarse amount of current to or from any one of the electrodes on the device. The fine portion of the current generation circuit preferably includes source and sink circuitry dedicated to each of the electrode on the device, which can comprise digital-to-analog current converters (DACs). The DACs also receives the above-noted reference current, which is amplified by the DACs in fine increments by appropriate selection of fine current control signals. When the coarse and fine current control circuitry are used in tandem, ample current with a fine current resolution can be achieved at any electrode and in a space- and power-efficient manner.
摘要翻译： 本文公开了用于植入式脉冲发生器（IPG）的植入式刺激器装置的当前一代架构。 电流源和接收电路都分为粗细部分，分别可以为IPG上的指定电极提供粗细和精细的电流分辨率。 粗糙部分分布在所有电极上，因此可以将电流吸收或吸收到任何电极。 粗略部分被分成多个级，每个级能够经由相关联的开关组，该器件对设备上的任何一个电极进行粗电流的吸收或吸收。 电流产生电路的优良部分优选地包括专用于器件上每个电极的源极和漏极电路，其可以包括数模转换器（DAC）。 DAC还接收上述参考电流，其通过适当选择精细电流控制信号以细微增量由DAC放大。 当粗调和精细电流控制电路串联使用时，可以在任何电极上以空间和功率有效的方式实现具有精细电流分辨率的充足电流。
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10.发明授权Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement 有权使用脉冲放置避免频率锁定在多通道神经刺激系统中的方法公开(公告)号：US08543200B2
公开(公告)日：2013-09-24
申请号：US12550237
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K. L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36082
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.
摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。
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