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    HYPERTROPHIC CARDIOMYOPATHY
    1.
    发明申请
    HYPERTROPHIC CARDIOMYOPATHY 有权
    超声心动图

    公开(公告)号：US20070207473A1

    公开(公告)日：2007-09-06

    申请号：US11555548

    申请日：2006-11-01

    申请人： Michael Ackerman ,  Sara Van Driest

    发明人： Michael Ackerman ,  Sara Van Driest

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  G01N2800/325

    摘要： This document provides methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals. For example, methods and materials for using mutations (e.g., mutations in ZASP and MYBPC3 nucleic acids) to identify, assess, and predict HCM in mammals (e.g., humans) are provided.

    摘要翻译： 本文件提供了与哺乳动物中增生性心肌病（HCM）的鉴别，评估和预测相关的方法和材料。 例如，提供了用于使用突变（例如，ZASP和MYBPC3核酸中的突变）鉴定，评估和预测哺乳动物（例如人）中的HCM的方法和材料。

    Block oligomers containing 1-hydrocarbyloxy-2,2,6,6-tetramethyl-4-piperidyl groups as stabilizers for organic materials
    2.
    发明授权
    Block oligomers containing 1-hydrocarbyloxy-2,2,6,6-tetramethyl-4-piperidyl groups as stabilizers for organic materials 有权
    含有1-烃氧基-2,2,6,6-四甲基-4-哌啶基的嵌段低聚物作为有机材料的稳定剂

    公开(公告)号：US06492440B1

    公开(公告)日：2002-12-10

    申请号：US09424139

    申请日：2000-06-09

    申请人： James Peter Galbo ,  Nicola Lelli ,  Valerio Borzatta ,  Jean-Pierre Wolf ,  Michael Ackerman ,  Piero Piccinelli ,  Ivan Orban

    发明人： James Peter Galbo ,  Nicola Lelli ,  Valerio Borzatta ,  Jean-Pierre Wolf ,  Michael Ackerman ,  Piero Piccinelli ,  Ivan Orban

    IPC分类号： C08K535

    CPC分类号： C07D401/14 ,  C08G73/0273 ,  C08G73/0644 ,  C08K5/34926

    摘要： A product obtainable by 1) reacting a compound of the formula (&agr;) with a compound of the formula (&bgr;) in a molar ratio of 1.2:1 to 1.4:1; 2) reacting the end groups of the formula (&ggr;) being present in the product of the reaction 1) with e.g. dibutylamine in a molar ratio of 2:1.7 to 2:3; the reactions 1) and 2) being carried out in an organic solvent in the presence of an inorganic base; and 3) transferring the groups of the formula being present in the product of the reaction 2) to groups of the formula said transfer being carried out by reacting the product of the reaction 2) with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst. The products obtained are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers such as polyolefins.

    摘要翻译： 可通过以下方式获得的产物：1）使式（α）的化合物与式（β）化合物的摩尔比为1.2:1至1.4:1; 2）使存在于反应1）的产物中的式（γ） 二丁胺摩尔比为2：1.7至2：3; 反应1）和2）在无机碱存在下在有机溶剂中进行; 和3）将本反应产物中存在的所述组合物转移到通过反应2）的产物与氢过氧化物在烃溶剂中在过氧化物分解 催化剂。 获得的产品可用作有机材料的光稳定剂，热稳定剂和氧化稳定剂，特别是合成聚合物如聚烯烃。

    Block oligomers containing 1-hydrocarbyloxy-2,2,6,6-tetramethyl-4-piperidyl groups as stabilizers for organic materials
    3.
    发明授权
    Block oligomers containing 1-hydrocarbyloxy-2,2,6,6-tetramethyl-4-piperidyl groups as stabilizers for organic materials 有权
    含有1-烃氧基-2,2,6,6-四甲基-4-哌啶基的嵌段低聚物作为有机材料的稳定剂

    公开(公告)号：US06409941B1

    公开(公告)日：2002-06-25

    申请号：US09424141

    申请日：1999-11-18

    申请人： James Peter Galbo ,  Nicola Lelli ,  Valerio Borzatta ,  Jean-Pierre Wolf ,  Michael Ackerman ,  Piero Piccinelli

    发明人： James Peter Galbo ,  Nicola Lelli ,  Valerio Borzatta ,  Jean-Pierre Wolf ,  Michael Ackerman ,  Piero Piccinelli

    IPC分类号： C07D40112

    CPC分类号： C07D401/14 ,  C08G73/0644 ,  C08K5/34926 ,  C08L23/02 ,  C08L79/02 ,  C08L2201/08 ,  C08L2666/20

    摘要： A product obtainable by transferring groups of formula (G-I) being present in a block oligomer having a polydispersity {overscore (M)}w/{overscore (M)}n of 1 to 1.7 and corresponding to formula (I) to groups of formula (Gu-II), wherein R1 is a hydrocarbyl radical or —O—R1 is oxyl; said transfer is carried out by reaction of the block oligomer with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst; n is a number from 2 to 14; R2 is for example C2-C12alkylene; A is for example —N(R4)(R5); R4 and R5 are for example C1-C18alkyl; R is preferably a group of formula (G-I) and B and B* have one of the meanings given for A; with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R and R2 has the same or a different meaning. The products are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.

    摘要翻译： 通过将具有多分散性（超核（M）} w / {超核（M）} n为1〜1.7，对应于式（I）的嵌段齐聚物中的式（GI） （Gu-II），其中R1是烃基或-O-R1是氧基; 所述转移通过在过氧化物分解催化剂存在下在烃溶剂中使嵌段低聚物与氢过氧化物反应来进行; n是从2到14的数字; R2是例如C 2 -C 12亚烷基; A是例如-N（R4）（R5）; R4和R5是例如C1-C18烷基; R优选为式（G-I）的基团，而B和B *具有对A给出的含义之一; 条件是在式（I）的各个反复单元中，基团B，R和R 2各自具有相同或不同的含义。 该产品可用作有机材料的光稳定剂，热稳定剂和氧化稳定剂，特别是合成聚合物。

    Cattle management system and method
    4.
    发明申请
    Cattle management system and method 有权

    公开(公告)号：US20060054092A1

    公开(公告)日：2006-03-16

    申请号：US11228020

    申请日：2005-09-14

    申请人： Neal Valencia ,  Michael Ackerman ,  Jim Carisch

    发明人： Neal Valencia ,  Michael Ackerman ,  Jim Carisch

    IPC分类号： A01K39/00

    CPC分类号： A01K29/00 ,  G06F19/00

    摘要： A cattle management system and method are provided for managing numerous routine and non-routine management activities. The system and method incorporate a data processing system wherein comprehensive data is gathered and maintained on each individual animal as well as on selected groups of animals. Preferably, a central database is used which allows enhanced functionality with respect to not only data entry and data transfer, but also with respect to providing system generated management recommendations. Some significant functionality of the present invention includes the ability to track the location of each individual animal by utilizing unique identification data for each animal, recording all monitored events that take place at each location during the animal's production cycle, and reporting the events and locations as required to government entities, financial institutions, and other entities within the cattle industry.

    Block oligomers containing 1-hydrocarbyloxy-2,2,6,6-tetramethyl-4-piperidyl groups as stabilizers for organic materials
    5.
    发明授权
    Block oligomers containing 1-hydrocarbyloxy-2,2,6,6-tetramethyl-4-piperidyl groups as stabilizers for organic materials 有权
    含有1-烃氧基-2,2,6,6-四甲基-4-哌啶基的嵌段低聚物作为有机材料的稳定剂

    公开(公告)号：US06403680B1

    公开(公告)日：2002-06-11

    申请号：US09424138

    申请日：1999-11-18

    申请人： James Peter Galbo ,  Nicola Lelli ,  Valerio Borzatta ,  Jean-Pierre Wolf ,  Michael Ackerman ,  Piero Piccinelli ,  Ivan Orban

    发明人： James Peter Galbo ,  Nicola Lelli ,  Valerio Borzatta ,  Jean-Pierre Wolf ,  Michael Ackerman ,  Piero Piccinelli ,  Ivan Orban

    IPC分类号： C08K534

    CPC分类号： C07D401/14 ,  C08K5/34926

    摘要： A product obtained by 1) reacting a compound of the formula (&agr;) with a compound of the formula (&bgr;) in a stoichiometric ratio to obtain a compound of the formula (&ggr;) 2) reacting the compound of the formula (&bgr;) with the compound of the formula (&ggr;) in a molar ratio of 0.4:1 to 0.75:1; 3) reacting the end groups of the formula (&dgr;) being present in the product of the reaction 2) with e.g. dibutylamine in a molar ratio of 2:1.7 to 2:3; the reactions 1) to 3) being carried out in an organic solvent in the presence of an inorganic base; and 4) transferring the groups of the formula being present in the product of the reaction 3) to groups of the formula said transfer being carried out by reacting the product of the reaction 3) with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst; R1 is in particular a hydrocarbyl radical, B is e.g. N-(2,2,6,6-tetramethyl-4-piperdyl)-butylamino, R is e.g. 2,2,6,6-tetramethyl-4-piperidyl and R2 is e.g. hexamethylene.

    摘要翻译： 通过以下方式获得的产物：1）以化学计量比使式（α）化合物与式（β）化合物反应得到式（γ）化合物2）使式（β）化合物与式 使摩尔比为0.4:1至0.75:1的式（γ）化合物; 3）使反应2）的产物中存在的式（delta）的端基与例如 二丁胺摩尔比为2：1.7至2：3; 反应1）〜3）在无机碱存在下在有机溶剂中进行; 和4）将反应3）中存在的配方的基团转移到通过在过氧化物分解催化剂存在下在烃溶剂中使反应3）的产物与氢过氧化物反应来进行的公式转移的基团 ; R1特别是烃基，B是例如。 N-（2,2,6,6-四甲基-4-哌啶基） - 丁基氨基， 2,2,6,6-四甲基-4-哌啶基，R 2是例如。 六亚甲基。

    Workpiece forming
    7.
    发明申请
    Workpiece forming 审中-公开
    工件成型

    公开(公告)号：US20050061424A1

    公开(公告)日：2005-03-24

    申请号：US10485182

    申请日：2002-08-07

    申请人： Michael Ackerman ,  Terry Flower ,  Allan Keevil ,  Jerome Way ,  Alan Jocelyn ,  Douglas Nash ,  Aravinda Kar

    发明人： Michael Ackerman ,  Terry Flower ,  Allan Keevil ,  Jerome Way ,  Alan Jocelyn ,  Douglas Nash ,  Aravinda Kar

    IPC分类号： B21D26/055 ,  B23K26/00 ,  B32B1/00 ,  B29C47/00

    CPC分类号： B21D26/055

    摘要： A method of forming a workpiece (18) comprises: holding the workpiece adjacent a mould (20); using a laser (30) to heat at least a part of the workpiece to a temperature sufficient to induce superplasticity; and applying a fluid pressure to the workpiece, so that it takes the shape of the mould. This has the advantage that the superplastic properties of the material can be used to form the workpiece precisely to the required shape, without needing to heat all of the processing chamber to the superplastic temperature. Before using the laser to heat the workpiece to its superplastic temperature, the laser can be used to heat the whole of the workpiece to a substantially uniform temperature to anneal it. Similarly, after using the laser to superplastically form the workpiece, the laser is used to heat the whole of the workpiece to a substantially uniform temperature to remove any residual stresses. This has the advantage that the whole of the forming can be carried out as a single process, in a single processing apparatus.

    摘要翻译： 一种形成工件（18）的方法包括：将工件保持在模具（20）附近; 使用激光器（30）将至少一部分工件加热到足以引起超塑性的温度; 并向工件施加流体压力，从而使其具有模具的形状。 这具有这样的优点：材料的超塑性能可用于将工件精确地形成为所需形状，而不需要将所有的处理室加热到超塑性温度。 在使用激光将工件加热到其超塑性温度之前，激光可用于将整个工件加热至基本均匀的温度以退火。 类似地，在使用激光器超塑性地形成工件之后，使用激光器将整个工件加热到基本均匀的温度以去除任何残余应力。 这具有以下优点：整个成型可以在单个处理装置中作为单个工艺进行。

    Method of genetic testing in heritable arrhythmia syndrome patients
    10.
    发明申请
    Method of genetic testing in heritable arrhythmia syndrome patients 审中-公开
    遗传性心律失常综合征患者基因检测方法

    公开(公告)号：US20050142591A1

    公开(公告)日：2005-06-30

    申请号：US10976086

    申请日：2004-10-27

    申请人： Michael Ackerman

    发明人： Michael Ackerman

    IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： A method of diagnosing heritable arrhythmia syndrome in a patient is disclosed. In one embodiment, the method comprises the steps of (a) isolating a nucleic acid sample from the patient and (b) comparing the nucleic acid sample to the compendium of novel DNA mutations disclosed in Table 1, wherein the comparison is to the mutations described from at least one of the genes selected from the group consisting of KCNQ1, KCNH2, SCN5A, and KCNE2.

    摘要翻译： 公开了一种诊断患者遗传性心律失常综合征的方法。 在一个实施方案中，该方法包括以下步骤：（a）从患者中分离核酸样品，和（b）将核酸样品与表1中公开的新型DNA突变纲要进行比较，其中比较与所描述的突变 来自选自KCNQ1，KCNH2，SCN5A和KCNE2的基因中的至少一种。