公开(公告)号：US20110066134A1

公开(公告)日：2011-03-17

申请号：US12755989

申请日：2010-04-07

申请人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

发明人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

IPC分类号： A61N1/30

CPC分类号： A61K31/137 ,  A61K9/0009 ,  A61K9/0014

摘要： Pharmaceutical drugs and formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface, such as a nail, are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafine and methods for administering terbinafine to a body surface via iontophoresis. When the drug source is introduced into the nail using a mask, terbinafine concentrations in peripheral areas of nail following iontophoretic treatment are less than drug concentrations directly under the mask. Further, differences in delivered drug concentrations is effectuated by creating drug delivery gradients. Drug can be delivered to dissimilar tissues based on different transfer efficiencies exhibited by the dissimilar tissues, resulting in higher percentage delivery in one tissue vs. another tissue.

摘要翻译： 描述了适用于其离子电渗疗法的药物和制剂，其提供了抗真菌药物至少一个身体表面（例如钉子）的离子电渗疗法递送。 还描述了适用于包含特比萘芬的离子电渗疗法的药物制剂以及通过离子电渗疗法将特比萘芬给予体表面的方法。 当使用掩模将药物源引入指甲时，离子电渗治疗后指甲周边区域的特比萘芬浓度低于掩模下方的药物浓度。 此外，通过产生药物递送梯度来实现递送的药物浓度的差异。 药物可以根据不同组织表现出的不同转移效率递送到不同的组织，导致一个组织中相对于另一个组织的较高百分比递送。

公开(公告)号：US20080051692A1

公开(公告)日：2008-02-28

申请号：US11565335

申请日：2006-11-30

申请人： John Petersen ,  Dennis Goldberg ,  James Kelland ,  Robert Ehteredge ,  Michael Barsness ,  Kuowei Chang

发明人： John Petersen ,  Dennis Goldberg ,  James Kelland ,  Robert Ehteredge ,  Michael Barsness ,  Kuowei Chang

IPC分类号： A61N1/30

CPC分类号： A61N1/303

摘要： An applicator for a device for electrokinetic delivery of medicament to a treatment site includes an applicator head having an active electrode, a matrix, and a medicament or a medicament and an electrically conductive carrier, carried by the matrix in electrical contact with the electrode. The cartridge includes a plurality of raised projections allowing the matrix and head to be ultrasonically welded one to the other. The electrode opens through a face of the head remote from the matrix for connection with an electrical connector carried by the device. A lid overlies the matrix and is releasably attached to a margin of the head. The lid includes layers of different materials with one of the layers formed of a metallic material having a discontinued interface with the lid and a tab carried by the lid.

摘要翻译： 用于将药物电动递送到治疗部位的装置的施加器包括具有活性电极，基质以及由电极与电极电接触的基质携带的药物或药物和导电载体的施用器头。 盒包括多个凸起突起，允许矩阵和头被彼此超声波焊接。 电极通过远离矩阵的头部的面打开，以与由该装置承载的电连接器连接。 盖子覆盖在基体上并且可释放地附接到头部的边缘。 盖子包括不同材料的层，其中一个层由金属材料形成，该金属材料具有与盖子不连续的界面和由盖子承载的翼片。

公开(公告)号：US20080312579A1

公开(公告)日：2008-12-18

申请号：US12139873

申请日：2008-06-16

申请人： Kuowei Chang ,  Dennis I. Goldberg ,  Robert W. Etheredge ,  Michael S. Barsness

发明人： Kuowei Chang ,  Dennis I. Goldberg ,  Robert W. Etheredge ,  Michael S. Barsness

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0412 ,  A61N1/0424 ,  A61N1/0428 ,  A61N1/0448

摘要： An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a segmented active electrode; a medicament matrix having one side abutting the segmented active electrode and another side adapted to contact a surface of skin over the treatment site, wherein the matrix includes at least one current direction barrier suppressing transverse current flow through the matrix.

摘要翻译： 一种用于将药物施用于哺乳动物使用者的治疗部位的电动装置，所述装置包括：分段活性电极; 药物基质，其一侧邻接所述分段的活性电极，另一侧适于在所述治疗部位接触皮肤表面，其中所述基质包括至少一个电流方向屏障，其阻止穿过所述基质的横向电流。

公开(公告)号：US20230285050A1

公开(公告)日：2023-09-14

申请号：US17999652

申请日：2021-05-26

申请人： Subir Ray ,  Kuowei Chang

发明人： Subir Ray ,  Kuowei Chang

IPC分类号： A61B17/34 ,  A61B17/04

CPC分类号： A61B17/3474 ,  A61B17/0469 ,  A61B17/3496 ,  A61B17/3498 ,  A61B2017/3454 ,  A61B2017/00349

摘要： The present invention provides devices and methods for laparoscopic access and wound closure. The device is in the form of a unitary needle device, which enables performance of several tasks, including penetration or puncture of fascia layers, insufflation of a body cavity with gas, and placing a suture for wound closure. In particular, the device features a blunt-tipped stylet having a hook or notch at the proximal end, which can be used to capture a suture.

公开(公告)号：US3931589A

公开(公告)日：1976-01-06

申请号：US453237

申请日：1974-03-21

申请人： Sol Aisenberg ,  Kuowei Chang

发明人： Sol Aisenberg ,  Kuowei Chang

IPC分类号： H01S3/097 ,  H01S3/22 ,  H01S3/03

CPC分类号： H01S3/09707 ,  H01S3/097

摘要： An improved ion-laser system utilizing a cold, perforated-wall hollow-cate electron-beam discharge to produce a high energy, high intensity self-collimated electron-beam to provide a high efficiency, high power continuous wave or pulsed ion-laser oscillations in both visible and ultra-violet ranges.

摘要翻译： 一种改进的离子激光系统，利用冷的穿孔壁中空阴极电子束放电来产生高能量，高强度的自准直电子束，以提供高效，高功率连续波或脉冲离子激光振荡 在可见光和紫外线范围内。