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    Controlling Drug Transport and Current in Iontophoretic Onychomycosis Treatment
    1.
    发明申请
    Controlling Drug Transport and Current in Iontophoretic Onychomycosis Treatment 审中-公开
    控制药物运输和离子电渗甲真菌治疗中的电流

    公开(公告)号：US20110066134A1

    公开(公告)日：2011-03-17

    申请号：US12755989

    申请日：2010-04-07

    申请人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

    发明人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

    IPC分类号： A61N1/30

    CPC分类号： A61K31/137 ,  A61K9/0009 ,  A61K9/0014

    摘要： Pharmaceutical drugs and formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface, such as a nail, are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafine and methods for administering terbinafine to a body surface via iontophoresis. When the drug source is introduced into the nail using a mask, terbinafine concentrations in peripheral areas of nail following iontophoretic treatment are less than drug concentrations directly under the mask. Further, differences in delivered drug concentrations is effectuated by creating drug delivery gradients. Drug can be delivered to dissimilar tissues based on different transfer efficiencies exhibited by the dissimilar tissues, resulting in higher percentage delivery in one tissue vs. another tissue.

    摘要翻译： 描述了适用于其离子电渗疗法的药物和制剂，其提供了抗真菌药物至少一个身体表面（例如钉子）的离子电渗疗法递送。 还描述了适用于包含特比萘芬的离子电渗疗法的药物制剂以及通过离子电渗疗法将特比萘芬给予体表面的方法。 当使用掩模将药物源引入指甲时，离子电渗治疗后指甲周边区域的特比萘芬浓度低于掩模下方的药物浓度。 此外，通过产生药物递送梯度来实现递送的药物浓度的差异。 药物可以根据不同组织表现出的不同转移效率递送到不同的组织，导致一个组织中相对于另一个组织的较高百分比递送。

    ELECTROKINETIC SYSTEM AND METHOD FOR DELIVERING METHOTREXATE
    2.
    发明申请
    ELECTROKINETIC SYSTEM AND METHOD FOR DELIVERING METHOTREXATE 审中-公开
    电动系统及其输送方法

    公开(公告)号：US20070185432A1

    公开(公告)日：2007-08-09

    申请号：US11538249

    申请日：2006-10-03

    申请人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Petersen

    发明人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Petersen

    IPC分类号： A61N1/30

    CPC分类号： A61B17/205 ,  A61M37/0015 ,  A61M2037/0061

    摘要： The electrokinetic methotrexate delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament, e.g., methotrexate, or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, methotrexate, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

    摘要翻译： 电动氨甲蝶呤递送系统包括至少一个施用器，其具有承载在施用器的非导电表面上的多个非导电微针。 相对表面由用于与有源电极接触的导电材料形成。 施用器包括在相对表面之间包含药物，例如甲氨蝶呤或其载体的基质。 当施用器被微针穿透皮肤施加到个体的皮肤上时，通过电源，有效电极，甲氨蝶呤或导电载体，目标治疗部位，个体的身体， 接地电极和电源，从而通过非导电微针将药物电动驱动到目标治疗部位。

    Electrokinetic delivery system and methods therefor
    4.
    发明申请
    Electrokinetic delivery system and methods therefor 审中-公开
    电动输送系统及其方法

    公开(公告)号：US20070066934A1

    公开(公告)日：2007-03-22

    申请号：US11228461

    申请日：2005-09-19

    申请人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Peterson

    发明人： Robert Etheredge ,  Dennis Goldberg ,  Phillip Friden ,  John Peterson

    IPC分类号： A61B17/20

    CPC分类号： A61B17/205 ,  A61M37/0015

    摘要： The electrokinetic medicament delivery system includes at least one applicator having a multiplicity of non-conductive micro-needles carried on a non-conductive surface of the applicator. The opposite surface is formed of electrically conductive material for contact with an active electrode. The applicator includes a matrix containing a medicament or a carrier therefor between the opposite surfaces. When the applicator is applied to the individual's skin with the micro-needles penetrating the skin, an electrical current is completed through the power source, the active electrode, medicament, or electrically conductive carrier therefor, the targeted treatment site, the individual's body, a ground electrode and the power supply, thereby electokinetically driving the medicament through the non-conductive micro-needles into the targeted treatment site.

    摘要翻译： 电动药物递送系统包括至少一个施用器，其具有承载在施用器的非导电表面上的多个非导电微针。 相对表面由用于与有源电极接触的导电材料形成。 施用器包括在相对表面之间包含药物或载体的基质。 当施用器被微针穿透皮肤施加到个体的皮肤上时，通过动力源，有效电极，药物或导电载体，目标治疗部位，个体的身体， 接地电极和电源，从而通过非导电微针将药物电动驱动到目标治疗部位。

    Drug delivery device having improved adhesion and attachment system for drug delivery device
    5.
    发明授权
    Drug delivery device having improved adhesion and attachment system for drug delivery device 有权
    药物输送装置具有改进的用于药物递送装置的粘附和附着系统

    公开(公告)号：US06585707B2

    公开(公告)日：2003-07-01

    申请号：US09315629

    申请日：1999-05-20

    申请人： Oz Cabiri ,  David Katz ,  Mario Rozanowich ,  Haim Danon ,  Joseph Gross ,  Izrail Tsals ,  Craig Brodeur ,  Robert Etheredge

    发明人： Oz Cabiri ,  David Katz ,  Mario Rozanowich ,  Haim Danon ,  Joseph Gross ,  Izrail Tsals ,  Craig Brodeur ,  Robert Etheredge

    IPC分类号： A61F1302

    CPC分类号： A61M5/14248 ,  A61M25/02 ,  A61M2025/0253 ,  A61M2025/0266

    摘要： A system adapted to be disposed between a rigid or semi-rigid device and human skin for reliably attaching the device to the skin for an extended period of time. The system includes a skin-contacting surface for adhering to human skin, and an opposed surface for attachment to a rigid or semi-rigid device. The system is attached along its opposed surface to a portion of the total area of the adjacent surface of the device. When the device is subjected to external stress, the stress is transmitted through the area of attachment and distributed to the unattached area. This minimises stress on the skin and reduces the chance of detachment from the skin.

    摘要翻译： 一种适于布置在刚性或半刚性装置与人体皮肤之间的系统，用于将装置可靠地连接到皮肤上较长时间。 该系统包括用于粘附到人体皮肤的皮肤接触表面和用于附接到刚性或半刚性装置的相对表面。 该系统沿其相对表面附接到装置的相邻表面的总区域的一部分。 当设备受到外部应力时，应力通过附件区域传递，并分配到未附着的区域。 这最大限度地减少了皮肤上的压力，减少了从皮肤脱落的机会。

    Method of making a multi-layer absorbent article
    7.
    发明授权
    Method of making a multi-layer absorbent article 失效
    制造多层吸收制品的方法

    公开(公告)号：US06177606B1

    公开(公告)日：2001-01-23

    申请号：US09329721

    申请日：1999-06-10

    申请人： Robert Etheredge ,  Marion Scocca

    发明人： Robert Etheredge ,  Marion Scocca

    IPC分类号： A61F1315

    CPC分类号： A61F13/26 ,  A61F13/2051 ,  Y10S604/904

    摘要： An absorbent article for absorption of bodily fluids is provided, including a layer of non-absorbent material defining a tunnel shaped loop and a central portion enclosed by the loop, and an absorbent material retained within the tunnel-shaped loop. The non-absorbent material includes a plurality of apertures through which fluid can flow to reach the absorbent material, and an overwrap material overlies the non-absorbent material to transport fluid over the surface of the non-absorbent material. Preferably the absorbent article is a tampon and the loop is ring shaped.

    摘要翻译： 提供了一种用于吸收体液的吸收制品，其包括限定隧道形环的非吸收材料层和由环包围的中心部分，以及保留在隧道状环内的吸收材料。 非吸收性材料包括多个孔，流体可以通过该孔流到达吸收材料，外覆材料覆盖在非吸收材料上，以将流体输送到非吸收材料的表面上。 优选地，吸收制品是棉条，并且环是环形的。

    Multi-layer absorbent article
    8.
    发明授权
    Multi-layer absorbent article 失效
    多层吸收制品

    公开(公告)号：US5928184A

    公开(公告)日：1999-07-27

    申请号：US833947

    申请日：1997-04-14

    申请人： Robert Etheredge ,  Marion Scocca

    发明人： Robert Etheredge ,  Marion Scocca

    IPC分类号： A61F13/20 ,  A61F13/26 ,  A61F13/15

    CPC分类号： A61F13/26 ,  A61F13/2051 ,  Y10S604/904

    摘要： An absorbent article for absorption of bodily fluids is provided, including a layer of non-absorbent material defining a tunnel shaped loop and a central portion enclosed by the loop, and an absorbent material retained within the tunnel-shaped loop. The non-absorbent material includes a plurality of apertures through which fluid can flow to reach the absorbent material, and an overwrap material overlies the non-absorbent material to transport fluid over the surface of the non-absorbent material. Preferably the absorbent article is a tampon and the loop is ring shaped.

    摘要翻译： 提供了一种用于吸收体液的吸收制品，其包括限定隧道形环的非吸收材料层和由环包围的中心部分，以及保留在隧道状环内的吸收材料。 非吸收性材料包括多个孔，流体可以通过该孔流到达吸收材料，外覆材料覆盖在非吸收材料上，以将流体输送到非吸收材料的表面上。 优选地，吸收制品是棉条，并且环是环形的。