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    Controlling Drug Transport and Current in Iontophoretic Onychomycosis Treatment
    1.
    发明申请
    Controlling Drug Transport and Current in Iontophoretic Onychomycosis Treatment 审中-公开
    控制药物运输和离子电渗甲真菌治疗中的电流

    公开(公告)号：US20110066134A1

    公开(公告)日：2011-03-17

    申请号：US12755989

    申请日：2010-04-07

    申请人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

    发明人： Michael Barsness ,  Shawn Davis ,  Robert Etheredge ,  Kuowei Chang ,  Hyun Kim

    IPC分类号： A61N1/30

    CPC分类号： A61K31/137 ,  A61K9/0009 ,  A61K9/0014

    摘要： Pharmaceutical drugs and formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface, such as a nail, are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafine and methods for administering terbinafine to a body surface via iontophoresis. When the drug source is introduced into the nail using a mask, terbinafine concentrations in peripheral areas of nail following iontophoretic treatment are less than drug concentrations directly under the mask. Further, differences in delivered drug concentrations is effectuated by creating drug delivery gradients. Drug can be delivered to dissimilar tissues based on different transfer efficiencies exhibited by the dissimilar tissues, resulting in higher percentage delivery in one tissue vs. another tissue.

    摘要翻译： 描述了适用于其离子电渗疗法的药物和制剂，其提供了抗真菌药物至少一个身体表面（例如钉子）的离子电渗疗法递送。 还描述了适用于包含特比萘芬的离子电渗疗法的药物制剂以及通过离子电渗疗法将特比萘芬给予体表面的方法。 当使用掩模将药物源引入指甲时，离子电渗治疗后指甲周边区域的特比萘芬浓度低于掩模下方的药物浓度。 此外，通过产生药物递送梯度来实现递送的药物浓度的差异。 药物可以根据不同组织表现出的不同转移效率递送到不同的组织，导致一个组织中相对于另一个组织的较高百分比递送。

    Rotating gripper wafer flipper
    8.
    发明申请
    Rotating gripper wafer flipper 审中-公开
    旋转夹具晶圆片

    公开(公告)号：US20060046376A1

    公开(公告)日：2006-03-02

    申请号：US11210059

    申请日：2005-08-23

    申请人： Willard Hofer ,  Shawn Davis ,  Joe Phillips

    发明人： Willard Hofer ,  Shawn Davis ,  Joe Phillips

    IPC分类号： H01L21/8238

    CPC分类号： H01L21/68707

    摘要： A wafer-handling apparatus for semiconductor wafers, the apparatus including a holding structure having wedge assemblies configured to hold and rotate a wafer about a first axis, the first axis extending generally perpendicular to a surface of the wafer. Further, a shaft is operatively coupled to the holding structure and configured to rotate the holding structure about a second axis, the second axis different than the first axis.

    摘要翻译： 一种用于半导体晶片的晶片处理装置，该装置包括具有楔形组件的保持结构，该楔形组件构造成围绕第一轴线保持和旋转晶片，第一轴线大致垂直于晶片的表面延伸。 此外，轴可操作地联接到保持结构并且构造成围绕第二轴线旋转保持结构，第二轴线不同于第一轴线。

    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS
    10.
    发明申请
    RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
    快速交付和/或取消流体

    公开(公告)号：US20110251562A1

    公开(公告)日：2011-10-13

    申请号：US13166611

    申请日：2011-06-22

    申请人： Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  Douglas A. Levinson ,  Mark Michelman

    发明人： Donald E. Chickering, III ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  Douglas A. Levinson ,  Mark Michelman

    IPC分类号： A61M5/00

    CPC分类号： A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

    摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

    摘要翻译： 本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽取或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。 例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。