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公开(公告)号：US5921982A
公开(公告)日：1999-07-13
申请号：US846739
申请日：1997-04-30
Applicant: Michael D. Lesh , Stuart D. Edwards
Inventor： Michael D. Lesh , Stuart D. Edwards
CPC classification number: A61B18/1492 , A61B2017/003 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00815 , A61B2018/00839 , A61B2018/1425 , A61B2018/1435 , A61B2090/3782 , A61N7/02
Abstract: A medical probe device for contacting tissue within the body a catheter tube having a control end and a probe end. The probe end includes a housing having a port. An element is located within the housing that is movable between a first position confined within the housing and a second position extending through the port outside the housing. The element has a distal tip adapted to penetrate a tissue region during movement between the first and second position. The element comprises an electrode for emitting electromagnetic radio frequency energy into the tissue region, or cannula with an interior lumen for conveying fluid to and from the tissue region, or a sensor for sensing temperature conditions in the tissue region.
Abstract translation: 一种医疗探针装置，用于使身体内的组织具有具有控制端和探针端的导管。 探针端部包括具有端口的壳体。 元件位于壳体内，其可在限制在壳体内的第一位置和延伸穿过壳体外部的端口的第二位置之间移动。 元件具有适于在第一和第二位置之间移动期间穿透组织区域的远侧末端。 该元件包括用于将电磁射频能量发射到组织区域中的电极，或具有用于向组织区域输送流体的内腔的插管或用于感测组织区域中的温度条件的传感器。
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2.发明授权公开(公告)号：US06716196B2
公开(公告)日：2004-04-06
申请号：US09797483
申请日：2001-02-28
Applicant: Michael D. Lesh , Thomas F. Kordis , Stuart D. Edwards
Inventor： Michael D. Lesh , Thomas F. Kordis , Stuart D. Edwards
IPC: A61M5178
CPC classification number: A61M25/0136 , A61B17/22 , A61B2017/00243 , A61B2017/22082 , A61B2017/3488 , A61B2018/00273 , A61B2018/00815 , A61B2018/1425 , A61B2018/1435 , A61B2090/3784 , A61M25/0084 , A61M25/0133 , A61M25/0147 , A61N7/02
Abstract: This is a method and an apparatus for the introduction of therapeutic compounds into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected therapeutic compound to be delivered to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.
Abstract translation: 这是用于将治疗化合物引入组织，特别是心脏组织的方法和装置。 所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除 。 这允许将所选择的治疗化合物递送到特定部位。 导管还可以包括可视化组件，其包括在身体的远端处的换能器。
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公开(公告)号：US20120035643A1
公开(公告)日：2012-02-09
申请号：US13274380
申请日：2011-10-17
Applicant: Alexander K. Khairkhahan , Andrew G.C. Frazier , Alan R. Klenk , Marc S. Kreidler , Stewart M. Kume , Darrell H. Ogi , Chad C. Roue , Erik J. van der Burg , Dino DeCicco , Michael D. Lesh
Inventor： Alexander K. Khairkhahan , Andrew G.C. Frazier , Alan R. Klenk , Marc S. Kreidler , Stewart M. Kume , Darrell H. Ogi , Chad C. Roue , Erik J. van der Burg , Dino DeCicco , Michael D. Lesh
IPC: A61M29/00
CPC classification number: A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/122 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00619 , A61B2017/00623 , A61B2017/081 , A61B2017/1205 , A61B2017/12095 , A61F2/01 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0071 , A61F2230/008 , A61M25/10 , A61M2025/1054 , A61M2210/125
Abstract: Disclosed is an adjustable occlusion device for use in a body lumen such as the left atrial appendage. The occlusion device is removably carried by a deployment catheter. The device may be enlarged or reduced to facilitate optimal placement or removal. Methods are also disclosed.
Abstract translation: 公开了一种用于体腔内的可调闭塞装置，例如左心耳。 闭塞装置可移除地由展开导管携带。 该装置可以被放大或缩小以便于最佳的放置或移除。 还公开了方法。
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公开(公告)号：US07988726B2
公开(公告)日：2011-08-02
申请号：US10715221
申请日：2003-11-17
Applicant: Jonathan J. Langberg , Michael D. Lesh
Inventor： Jonathan J. Langberg , Michael D. Lesh
IPC: A61F2/24
CPC classification number: A61F2/2451 , A61F2/2466 , A61N2001/0585
Abstract: An implantable device is positioned within the coronary sinus and tightened around the mitral annulus to reduce mitral valve regurgitation. The device carries at least one electrode, in electronic communication with a cardiac rhythm management device.
Abstract translation: 植入式装置位于冠状窦内并且紧固在二尖瓣环周围以减少二尖瓣反流。 该装置携带至少一个与心律管理装置电子通信的电极。
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公开(公告)号：US20090221996A1
公开(公告)日：2009-09-03
申请号：US12464473
申请日：2009-05-12
Applicant: Michael D. Lesh
Inventor： Michael D. Lesh
CPC classification number: A61B18/1492 , A61B18/00 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002 , A61N7/02
Abstract: This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle.
Abstract translation: 本发明是适于在肺静脉中形成圆周传导阻滞的周缘消融装置组件。 该组件包括圆周消融元件，其适于沿着围绕肺静脉管腔的肺静脉壁消融组织的周缘区域，从而横切肺静脉的导电性，以抵抗沿着其纵向轴线并进入左心房的传导。 周向消融元件包括可膨胀构件，其具有可从径向收缩位置到径向扩张位置的可调节的工作长度。 赤道带包围工作长度的外表面，并且适于在由消融致动器致动时消融邻近的组织。 赤道带相对于可扩展构件的纵向轴线具有相对于工作长度窄的长度，并且当工作长度处于径向扩张位置时也比其圆周短得多。 绝缘体的图案可以包括在消融元件上，否则将跨越工作长度以形成所描述的赤道带。 可膨胀构件还适于在其口部的区域中符合肺静脉，例如通过提供大量径向顺应性或通过沿具有远端减小外径的工作长度提供锥形。 在组合组件中邻近周缘消融元件提供线性消融元件，该组合组件适用于在左心室的肺静脉口区域中的侵入性较小的“迷宫”型手术。
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Patent Agency Ranking
公开(公告)号：US20090198331A1
公开(公告)日：2009-08-06
申请号：US12024846
申请日：2008-02-01
Applicant: Randy J. Kesten , Michael D. Lesh
Inventor： Randy J. Kesten , Michael D. Lesh
IPC: A61F2/12
CPC classification number: A61F2/12
Abstract: An implantable prosthesis is provided having a membrane which holds a flowable substance. The membrane is separated into a first chamber and a second chamber with the first and second chambers being fluidly coupled via an orifice. The orifice has a size which may be adjusted by the user after implanting the prosthesis into the patient.
Abstract translation: 提供具有保持可流动物质的膜的可植入假体。 膜被分离成第一室和第二室，其中第一和第二室通过孔流体耦合。 孔口具有在将假体植入病人之后可由使用者调节的尺寸。
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公开(公告)号：US20090198328A1
公开(公告)日：2009-08-06
申请号：US12024826
申请日：2008-02-01
Applicant: Randy J. Kesten , Michael D. Lesh
Inventor： Randy J. Kesten , Michael D. Lesh
IPC: A61F2/12
CPC classification number: A61F2/12
Abstract: An implantable prosthesis is provided having a membrane which holds a flowable substance. The membrane is separated into a first chamber and a second chamber with the first and second chambers being fluidly coupled via an orifice. The orifice has a size which may be adjusted by the user after implanting the prosthesis into the patient.
Abstract translation: 提供具有保持可流动物质的膜的可植入假体。 膜被分离成第一室和第二室，其中第一和第二室通过孔流体耦合。 孔口具有在将假体植入病人之后可由使用者调节的尺寸。
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公开(公告)号：US07025756B2
公开(公告)日：2006-04-11
申请号：US10861691
申请日：2004-06-04
Applicant: Andrew G. C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
Inventor： Andrew G. C. Frazier , Michael D. Lesh , Chad C. Roue , Erik J. van der Burg
IPC: A61M31/00
CPC classification number: A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
Abstract: Disclosed is an anastomosis catheter, for achieving a tissue to tissue or synthetic graft to tissue attachment. The catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may be used to achieve end to end or end to side anastomoses. Methods are also disclosed.
Abstract translation: 公开了一种用于实现组织到组织或合成移植物到组织附着的吻合导管。 导管包括多个可展开的组织锚，其可以横向地布置到周围组织中。 锚可以用于实现端对端或端到端吻合。 还公开了方法。
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公开(公告)号：US06997925B2
公开(公告)日：2006-02-14
申请号：US10274729
申请日：2002-10-21
Applicant: Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
Inventor： Mark A. Maguire , Michael D. Lesh , James C. Peacock, III , Edward L. Carcamo
IPC: A61B18/18
CPC classification number: A61B18/1492 , A61B18/00 , A61B18/08 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/00065 , A61B2018/00101 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00238 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2018/143 , A61B2018/1432 , A61B2218/002 , A61M25/1002 , A61N7/02
Abstract: This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.
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公开(公告)号：US06855144B2
公开(公告)日：2005-02-15
申请号：US10233264
申请日：2002-08-30
Applicant: Michael D. Lesh
Inventor： Michael D. Lesh
CPC classification number: A61B18/1492 , A61B18/1815 , A61B2017/00243 , A61B2017/22038 , A61B2017/22054 , A61B2017/22067 , A61B2018/00011 , A61B2018/0016 , A61B2018/00214 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00369 , A61B2018/00375 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839 , A61B2018/00898 , A61B2018/00994 , A61B2218/002
Abstract: A tissue ablation device creates long linear lesions along a body space wall of an animal, and primarily between adjacent pulmonary vein ostia in a left atrial wall. An ablation element includes first and second ends that are bordered by first and second anchors. The anchors are adapted to secure the ablation element ends at predetermined first and second locations along the body space wall such that the ablation element is adapted to ablate an elongate region of tissue between those locations. The anchors may be guidewire tracking members, each including a bore adapted to receive and track over a guidewire, and may anchor within adjacent pulmonary vein ostia when the engaged guidewires are positioned within the respective veins. Stop members may be provided on the guidewires and may be adapted for positioning the relative anchors or for forcing the anchors to fit snugly within the vein ostia. A conduit passageway through the catheter houses a stiffening stylet which may be advanced into the region of the ablation element in order to impart a shape to that element to conform it to a predetermined region of anatomy, or to stiffen the underlying catheter in order to advance the assembly into remote anatomy.
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