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公开(公告)号：US5932726A
公开(公告)日：1999-08-03
申请号：US838838
申请日：1997-04-11
申请人： Michael Ernest Pierce , Anusuya Choudhury , Rodney Lawrence Parsons, Jr. , Lilian Alicia Radesca
发明人： Michael Ernest Pierce , Anusuya Choudhury , Rodney Lawrence Parsons, Jr. , Lilian Alicia Radesca
IPC分类号： A61K31/535 , A61P31/18 , A61P43/00 , C07D265/18 , C07D265/16
CPC分类号： C07D265/18 , Y02P20/55
摘要： The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
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公开(公告)号：US20050026903A1
公开(公告)日：2005-02-03
申请号：US10881628
申请日：2004-06-30
申请人： Anusuya Choudhury , Jeffrey Grimm , Jimmy Liang , Neelakandha Mani , Kirk Sorgi
发明人： Anusuya Choudhury , Jeffrey Grimm , Jimmy Liang , Neelakandha Mani , Kirk Sorgi
IPC分类号： A61K31/16 , A61K31/19 , A61K31/445 , A61K31/55 , C07D231/12 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/06
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D409/06
摘要： There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, and methods of making the same.
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公开(公告)号：US08278446B2
公开(公告)日：2012-10-02
申请号：US11766257
申请日：2007-06-21
IPC分类号： C07D239/48 , C07D239/50 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D413/04 , C07D417/12
摘要： The present invention is directed to a process for chemoselective substitution on a halopyrimidine carboxaldehyde having multiple reactive sites and subsequent stereoselective oxime formation.
摘要翻译： 本发明涉及一种在具有多个反应位点和随后的立体选择性肟形成的卤代嘧啶甲醛上进行化学选择性取代的方法。
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4.发明授权Process for the preparation of piperazinyl and diazepanyl benzamide derivatives 有权制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的方法公开(公告)号：US07893257B2
公开(公告)日：2011-02-22
申请号：US11953262
申请日：2007-12-10
申请人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
发明人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
IPC分类号： C07D413/10
CPC分类号： C07D413/10 , C07D241/04 , C07D401/10 , C07D403/10 , Y02P20/55
摘要： The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
摘要翻译： 本发明涉及用于制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的新方法，其可用于治疗由组胺受体介导的病症和病症，优选H3受体。
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公开(公告)号：US08569494B2
公开(公告)日：2013-10-29
申请号：US12910920
申请日：2010-10-25
申请人： Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Gingsee Lee , Garrick Packard , Jingjing Zhao , Patrick Anthony Jokiel , Deborah Mortensen , Jennifer Riggs , Juan Antonio Gamboa , Marie Georges Beauchamps , Matthew Michael Kreilein , Mohit Atul Kothare , Sophie Perrin-Ninkovic , Philip James Pye , William Wei-Hwa Leong , Jan Elsner , Anusuya Choudhury
发明人： Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Gingsee Lee , Garrick Packard , Jingjing Zhao , Patrick Anthony Jokiel , Deborah Mortensen , Jennifer Riggs , Juan Antonio Gamboa , Marie Georges Beauchamps , Matthew Michael Kreilein , Mohit Atul Kothare , Sophie Perrin-Ninkovic , Philip James Pye , William Wei-Hwa Leong , Jan Elsner , Anusuya Choudhury
IPC分类号： C07D471/00
CPC分类号： C07D471/04 , C07D241/20 , C07D487/04 , C07D498/14 , C07D519/00
摘要： Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.
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公开(公告)号：US5925789A
公开(公告)日：1999-07-20
申请号：US55480
申请日：1998-04-06
申请人： Michael E. Pierce , Cheng Y. Chen , Anusuya Choudhury , Lilian A. Radesca , Lushi Tan , Dalian Zhao
发明人： Michael E. Pierce , Cheng Y. Chen , Anusuya Choudhury , Lilian A. Radesca , Lushi Tan , Dalian Zhao
IPC分类号： C07D265/16 , A61P31/18 , A61P37/04 , C07C213/00 , C07C213/02 , C07C215/68 , C07C215/70 , C07C217/58 , C07C221/00 , C07C225/22 , C07D265/18 , C07C209/18
CPC分类号： C07D265/18 , C07C213/00 , C07C213/02 , C07C221/00 , C07C2101/02
摘要： The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
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7.发明申请PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES 有权制备哌嗪和二氮茚衍生物衍生物的方法公开(公告)号：US20080171870A1
公开(公告)日：2008-07-17
申请号：US11953262
申请日：2007-12-10
申请人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
发明人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
IPC分类号： C07D413/00 , C07D295/00
CPC分类号： C07D413/10 , C07D241/04 , C07D401/10 , C07D403/10 , Y02P20/55
摘要： The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
摘要翻译： 本发明涉及用于制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的新方法，其可用于治疗由组胺受体介导的病症和病症，优选H3受体。
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8.发明授权Process for the preparation of piperazinyl and diazepanyl benzamide derivatives 有权制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的方法公开(公告)号：US08680273B2
公开(公告)日：2014-03-25
申请号：US12987370
申请日：2011-01-10
申请人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
发明人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
IPC分类号： C07D241/04
CPC分类号： C07D413/10 , C07D241/04 , C07D401/10 , C07D403/10 , Y02P20/55
摘要： The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
摘要翻译： 本发明涉及用于制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的新方法，其可用于治疗由组胺受体介导的病症和病症，优选H3受体。
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9.发明申请PROCESS FOR THE PREPARATION OF PIPERAZINYL AND DIAZEPANYL BENZAMIDE DERIVATIVES 有权制备哌嗪和二氮茚衍生物衍生物的方法公开(公告)号：US20110105752A1
公开(公告)日：2011-05-05
申请号：US12987370
申请日：2011-01-10
申请人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
发明人： Anusuya Choudhury , Jeffrey S. Grimm , Kirk L. Sorgi , David Palmer , Jing Liu
IPC分类号： C07D241/04
CPC分类号： C07D413/10 , C07D241/04 , C07D401/10 , C07D403/10 , Y02P20/55
摘要： The present invention is directed to a novel process for the preparation of piperazinyl and diazepanyl benzamide derivatives, useful for the treatment of disorders and conditions mediated by a histamine receptor, preferably the H3 receptor.
摘要翻译： 本发明涉及用于制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的新方法，其可用于治疗由组胺受体介导的病症和病症，优选H3受体。
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10.发明申请PROCESS FOR THE PREPARATION OF TRI-SUBSTITUTED PYRIDINE AND TRI-SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL AS GDIR AGONISTS 审中-公开制备三取代的吡啶和三取代的吡嗪衍生物作为GDIR激动剂有用的方法公开(公告)号：US20100113479A1
公开(公告)日：2010-05-06
申请号：US12608014
申请日：2009-10-29
申请人： Anusuya Choudhury , Michael Reuman
发明人： Anusuya Choudhury , Michael Reuman
IPC分类号： A61K31/497 , C07D239/34 , A61P3/10
CPC分类号： C07D401/14
摘要： The present invention is directed to novel processes for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives, useful as glucose dependent insulinotropic receptor agonist, for the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.
摘要翻译： 本发明涉及用于制备三取代吡啶和三取代嘧啶衍生物的新方法，其可用作葡萄糖依赖性促胰岛激素受体激动剂，用于治疗代谢相关疾病及其并发症，例如糖尿病和肥胖症。
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