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公开(公告)号：US20080176898A1
公开(公告)日：2008-07-24
申请号：US11587318
申请日：2005-04-14
申请人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
发明人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
IPC分类号： A61K31/445 , C07D211/06 , A61K31/195 , A61P9/00 , C07C229/06
CPC分类号： C07D211/62 , C07C235/34 , C07C235/36 , C07D205/04 , C07D207/08 , C07D211/60
摘要： The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.
摘要翻译： 本发明涉及苯乙酰胺，其制备方法及其用于制备用于治疗和/或预防人和动物尤其是心血管疾病疾病的药物。
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公开(公告)号：US20060154912A1
公开(公告)日：2006-07-13
申请号：US10537623
申请日：2003-11-28
申请人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： A61K31/455 , A61K31/397 , A61K31/195 , A61K31/445
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。
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公开(公告)号：US07498460B2
公开(公告)日：2009-03-03
申请号：US10537623
申请日：2003-11-28
申请人： Michael Härter , Jens Ergüden , Frank Wunder , Hanna Tinel , Johannes Köbberling , Eva-Maria Becker , Klaus Münter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Bärfacker , Walter Hübsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Härter , Jens Ergüden , Frank Wunder , Hanna Tinel , Johannes Köbberling , Eva-Maria Becker , Klaus Münter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Bärfacker , Walter Hübsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： C07C229/10
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。
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公开(公告)号：US08173704B2
公开(公告)日：2012-05-08
申请号：US12083509
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/19 , A61K31/195 , C07C59/00 , C07C65/03 , C07C321/00
CPC分类号： C07C59/68 , C07C229/14 , C07D249/12 , C07D257/04 , C07D271/07 , C07D271/113
摘要： The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二氟苯酚衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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5.发明申请Tetrazole Derivatives and Their Use for the Treatment of Cardiovascular Diseases 有权四唑衍生物及其用于治疗心血管疾病的用途公开(公告)号：US20090215843A1
公开(公告)日：2009-08-27
申请号：US12085543
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/395 , C07D257/04 , A61P9/00
CPC分类号： C07D257/04
摘要： The present application relates to novel tetrazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型四唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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公开(公告)号：US09018258B2
公开(公告)日：2015-04-28
申请号：US13312320
申请日：2011-12-06
申请人： Thomas Lampe , Michael G. Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andŕeas Knorr , Peter Kolkhof , Elisabeth Woltering
发明人： Thomas Lampe , Michael G. Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andŕeas Knorr , Peter Kolkhof , Elisabeth Woltering
IPC分类号： A61K31/196 , C07C233/55 , C07C231/02 , C07C233/24
CPC分类号： C07C231/02 , A61K31/196 , C07C233/24 , C07C233/55
摘要： The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的1-苄基环烷基羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 用于治疗和/或预防心血管疾病。
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公开(公告)号：US08796335B2
公开(公告)日：2014-08-05
申请号：US13431934
申请日：2012-03-27
申请人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195 , C07C45/00
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US20120022084A1
公开(公告)日：2012-01-26
申请号：US13111856
申请日：2011-05-19
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Walter Kroh , Andreas Knorr , Eva-Maria Becker , Frank Wunder , Volkhart Min-Jian Li , Elke Hartmann , Joachim Mittendorf , Karl-Heinz Schlemmer , Rolf Jautelat , Donald Bierer
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Walter Kroh , Andreas Knorr , Eva-Maria Becker , Frank Wunder , Volkhart Min-Jian Li , Elke Hartmann , Joachim Mittendorf , Karl-Heinz Schlemmer , Rolf Jautelat , Donald Bierer
IPC分类号： A61K31/506 , A61P9/04 , A61P7/00 , A61P9/12 , A61P9/10 , A61P13/12 , C07D471/04 , A61P9/00
CPC分类号： A61K31/506 , A61K45/06 , C07C57/145 , C07C309/04 , C07C309/05 , C07D471/04
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的5-氟-1H-吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们用于制备用于治疗和/ 或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20100168240A1
公开(公告)日：2010-07-01
申请号：US12529713
申请日：2008-03-15
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
IPC分类号： A61K31/194 , C07C65/28 , A61P9/04 , A61P9/12 , A61P9/10
CPC分类号： C07C65/28
摘要： The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本发明涉及式（I）的新型取代二苯甲酸衍生物，其中A代表式（II）或（III）的基团，其制备方法及其在治疗和/或预防疾病中的用途 。 本发明还涉及所述物质在制备药物中用于治疗和/或预防疾病的用途，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20090291993A1
公开(公告)日：2009-11-26
申请号：US12083509
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/41 , A61K31/195 , A61K31/19 , C07D257/04 , C07C229/00 , C07C59/00
CPC分类号： C07C59/68 , C07C229/14 , C07D249/12 , C07D257/04 , C07D271/07 , C07D271/113
摘要： The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二氟苯酚衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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