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    Stearoyl-CoA desaturase assay
    3.
    发明申请
    Stearoyl-CoA desaturase assay 审中-公开
    硬脂酰-CoA去饱和酶测定

    公开(公告)号：US20060281071A1

    公开(公告)日：2006-12-14

    申请号：US11448198

    申请日：2006-06-07

    申请人： James Ntambi ,  Makoto Miyazaki

    发明人： James Ntambi ,  Makoto Miyazaki

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  C12Q1/48 ,  C12P7/64 ,  A61K31/202 ,  C12N1/18

    CPC分类号： C12P7/64 ,  C12N9/0083 ,  C12Q1/26 ,  G01N2500/00

    摘要： A yeast-based method for identifying an agent that can modulate the activity of a human or mouse stearoyl-CoA desaturase (SCD) is disclosed. Further disclosed are substrate specificities of various human and mouse SCDs, which facilitate the identification of modulators for human and mouse SCDs.

    摘要翻译： 公开了一种用于鉴定可调节人或小鼠硬脂酰辅酶A去饱和酶（SCD）的活性的试剂的基于酵母的方法。 还公开了各种人和小鼠SCD的底物特异性，其有利于鉴定人和小鼠SCD的调节剂。

    Stearoyl-CoA desaturase 4 gene
    4.
    发明申请
    Stearoyl-CoA desaturase 4 gene 有权
    硬脂酰CoA去饱和酶4基因

    公开(公告)号：US20050278795A1

    公开(公告)日：2005-12-15

    申请号：US11147606

    申请日：2005-06-08

    申请人： James Ntambi ,  Makoto Miyazaki

    发明人： James Ntambi ,  Makoto Miyazaki

    IPC分类号： A01K67/00 ,  A01K67/027 ,  A61B5/04 ,  C07H21/04 ,  C12N9/02 ,  C12N9/04 ,  C12N15/09

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0362 ,  C12N9/001 ,  C12N9/0083

    摘要： The cloning of a fourth mouse SCD gene, mSCD4, as well as its corresponding cDNA and amino acid sequences are disclosed. Mouse SCD4 is expressed mainly in the heart tissue and synthesizes the bulk of monounsaturated fatty acids in the heart. The disclosure here enables new tools (e.g., nucleic acids, polypeptides, antibodies, vectors, recombinant cells, and transgenic and knock-out animals) for studying the function of various SCD isoforms and their connection to various disease conditions. New tools for converting saturated fatty acyl-CoA to monounsaturated acyl-CoA and for identifying SCD modulators including isoform-specific modulators are also enabled. In addition, given that accumulation of lipid in the heart (fatty heart) can have deleterious consequences, the present invention also provides a new prevention and treatment target for fatty heart as well as methods for screening candidate drugs.

    摘要翻译： 公开了第四只小鼠SCD基因mSCD4的克隆及其相应的cDNA和氨基酸序列。 小鼠SCD4主要在心脏组织中表达并合成心脏中大部分单不饱和脂肪酸。 这里的公开使得能够研究各种SCD同种型的功能及其与各种疾病状况的连接的新工具（例如，核酸，多肽，抗体，载体，重组细胞和转基因和敲除动物）。 用于将饱和脂肪酰基辅酶A转化为单不饱和酰基辅酶A和用于鉴定包括异构体特异性调节剂在内的SCD调节剂的新工具也得以实现。 此外，由于脂质在心脏（脂肪心脏）中的积累可能具有有害的后果，本发明还提供了用于脂肪心脏的新的预防和治疗靶标以及用于筛选候选药物的方法。

    Vitamin D analogs for obesity prevention and treatment
    5.
    发明申请
    Vitamin D analogs for obesity prevention and treatment 有权
    用于肥胖预防和治疗的维生素D类似物

    公开(公告)号：US20050119242A1

    公开(公告)日：2005-06-02

    申请号：US10997698

    申请日：2004-11-24

    申请人： Hector DeLuca ,  Margaret Clagett-Dame ,  Jamie Ahrens ,  James Ntambi ,  Brian Thomson

    发明人： Hector DeLuca ,  Margaret Clagett-Dame ,  Jamie Ahrens ,  James Ntambi ,  Brian Thomson

    IPC分类号： A61K31/59 ,  A61K31/592 ,  A61K31/593

    CPC分类号： A61K31/59 ,  A61K31/592 ,  A61K31/593

    摘要： Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at least one analog of 1α,25-dihydroxyvitamin D3 or 1α,25-dihydroxyvitamin D2 or a pharmaceutical composition that includes such an analog to a subject in need thereof. The analog may be a 19-nor vitamin D analog such as a compound of formula IA, a compound of formula IB, or a mixture thereof where the variables R1, R2, and R3 have the values described herein.

    摘要翻译： 用于治疗和预防肥胖症，抑制脂肪细胞分化，抑制增加的SCD-1基因转录和/或减少受试者体内脂肪的方法包括施用至少一种类似物的1α，25-二羟基维生素D 3或 1α，25-二羟基维生素D 2 N或包含与有需要的受试者类似的药物组合物。 类似物可以是19-或维生素D类似物，例如式IA化合物，式IB化合物或其混合物，其中变量R 1，R 2， >，且R 3具有本文所述的值。