公开(公告)号：US4355646A

公开(公告)日：1982-10-26

申请号：US210656

申请日：1980-11-26

申请人： Michael J. Kallok ,  John D. Doring

发明人： Michael J. Kallok ,  John D. Doring

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61N1/056

摘要： A lead having multiple electrodes which is transvenously implanted for use in standby defibrillation of patients having a high risk of ventricular fibrillation. The lead employs four electrodes. The two distal electrodes have a spacing for optimal measurement of impedance changes due to mechanical contractions. This impedance measurement is used for mechanical sensing of normal cardiac activity. The electrode at the very distal tip terminates in a hemispherical shape. Two proximal electrodes are closely spaced and located at a distance from the two distal electrodes which ensures their placement within the superior vena cava whenever the distal electrodes are placed within the right ventricular apex. The body of the lead uses drawn brazed strand conductors wound triaxially for maximum flexibility, minimum cross-sectional area and the required high current carrying capability. At the proximal end of the lead, three connectors are used to electrically couple the lead to an implantable pulse generator. The two distal electrodes are electrically separated and each terminates in a separate proximal connector. The two proximal electrodes are electrically coupled to a single proximal connector. A stylet is employed to aid in implantation.

摘要翻译： 具有多个电极的导线，其被转移植入以用于具有高心室颤动风险的患者的待机除颤。 铅使用四个电极。 两个远端电极具有用于由于机械收缩而最佳测量阻抗变化的间隔。 该阻抗测量用于正常心脏活动的机械感测。 在非常远的尖端处的电极终止于半球形。 两个近端电极紧密间隔开并且位于与两个远端电极相距一定距离处，每当远端电极置于右心室顶点内时，确保它们位于上腔静脉内。 引线的主体使用三维缠绕的钎焊绞线导体，以获得最大的灵活性，最小的横截面积和所需的高电流承载能力。 在引线的近端，使用三个连接器将引线电耦合到可植入的脉冲发生器。 两个远端电极是电气分离的，并且每个终端在单独的近端连接器中。 两个近端电极电耦合到单个近端连接器。 采用探针以辅助植入。

公开(公告)号：US06976967B2

公开(公告)日：2005-12-20

申请号：US10079172

申请日：2002-02-19

申请人： Roger Dahl ,  Michael J. Kallok ,  Steve Sundquist

发明人： Roger Dahl ,  Michael J. Kallok ,  Steve Sundquist

IPC分类号： A61B5/11 ,  A61B5/107 ,  A61B8/08 ,  A61B8/12 ,  A61N1/05 ,  A61N1/08 ,  A61N1/365 ,  A61N1/39 ,  A61B5/04

CPC分类号： A61B5/1076 ,  A61B8/12 ,  A61N1/056 ,  A61N1/08

摘要： An electrical lead includes an elongate body having a proximal end, and a sensing unit capable of resolving a change in a spatial configuration of the electrical lead. A medical device includes a control unit, an elongate body having a proximal end coupled with the control unit, and a sensing unit capable of resolving a change in a spatial configuration of the electrical lead and relating it to the amount of blood ejected from the heart. A method includes receiving a signal transmitted from a lead disposed within a heart and determining a change in a dimension of the heart, due to the heart beating, based upon the signal.

摘要翻译： 电引线包括具有近端的细长主体和能够解决电引线的空间结构变化的感测单元。 医疗设备包括控制单元，具有与控制单元耦合的近端的细长主体，以及能够解决电引线的空间结构变化并将其与从心脏喷出的血液量相关联的感测单元 。 一种方法包括接收从设置在心脏内的导线发送的信号，并且基于该信号确定心脏的心脏尺寸的变化。

公开(公告)号：US5324309A

公开(公告)日：1994-06-28

申请号：US951622

申请日：1992-09-25

申请人： Michael J. Kallok

发明人： Michael J. Kallok

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61N1/3918

摘要： A method and apparatus for cardioversion and defibrillation. The apparatus is provided with two pairs of cardioversion or defibrillation electrodes, and delivers pulses sequentially between said first and second pairs of electrodes, such that the first pulse overlaps the second pulse for a time interval of at least about one millisecond. During the overlap time of the first and second pulses, a defibrillation pulse vector intermediate that defined by the two electrode pairs individually is provided.

摘要翻译： 一种用于心脏复律和除颤的方法和装置。 该装置设置有两对心脏复律或除颤电极，并且在所述第一和第二对电极之间顺序地传送脉冲，使得第一脉冲与第二脉冲重叠至少约一毫秒的时间间隔。 在第一和第二脉冲的重叠时间期间，提供了由两个电极对单独限定的除颤脉冲矢量中间。

公开(公告)号：US4499907A

公开(公告)日：1985-02-19

申请号：US441887

申请日：1982-11-15

申请人： Michael J. Kallok ,  Gene A. Bornzin

发明人： Michael J. Kallok ,  Gene A. Bornzin

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61N1/056

摘要： A transvenous cardioversion lead for use in standby cardioversion in patients who have a high risk of ventricular tachycardia or fibrillation, adapted for use with presently available external defibrillation units. The lead is provided with energy-reducing or energy-limiting circuitry to prevent the inappropriately high energy levels which may be generated by external defibrillation units from causing injury to the patient while preserving the beneficial waveform of the defibrillation pulse. The lead is further provided with at least three electrodes, two for location in the ventricle, at least one for location in the superior vena cava. The lead is so constructed that the superior vena cava electrode and one of the ventricular electrodes may be used for cardioversion, while the two ventricular electrodes may be used for cardiac pacing and sensing.

摘要翻译： 经心脏复律导联用于患有心室性心动过速或颤动风险高的患者的待机复律，适用于目前可用的外部除颤单元。 该引线设置有能量减少或能量限制电路，以防止外部除颤单元在保留除颤脉冲的有益波形的同时对患者造成伤害可能产生的不适当的高能量水平。 引线还设置有至少三个电极，两个用于在心室中定位，至少一个用于位于上腔静脉中。 铅的结构使得上腔静脉电极和心室电极之一可用于心脏复律，而两个心室电极可用于心脏起搏和感测。

公开(公告)号：US08177801B2

公开(公告)日：2012-05-15

申请号：US12405765

申请日：2009-03-17

申请人： Michael J. Kallok ,  Gary M. Petrucci

发明人： Michael J. Kallok ,  Gary M. Petrucci

IPC分类号： A61B17/22

CPC分类号： A61B17/320758 ,  A61B2017/22042 ,  A61B2017/320004 ,  A61B2017/320766

摘要： A high-speed atherectomy device is disclosed, for abrading a blockage (stenosis) in the interior of a lumen (artery). The device uses a rapidly rotating drive shaft that includes an eccentric abrasive element that has its center of mass laterally offset from the rotational axis of the drive shaft. As the drive shaft rotates, centrifugal force drives the eccentric abrasive element outward, so that it traces an abrading diameter at high rotational speeds that is larger than its rest diameter. The drive shaft includes counterweights on both sides of the abrasive element, which may stabilize operation at high rotational speeds. In some cases, the counterweights are also eccentric, with their centers of mass laterally offset from the rotational axis in the opposite direction as that of the abrasive element. The counterweights are longitudinally separated from the abrasive element, and in some cases, the separations are adjustable and/or controllable. In some cases, the guide wire may be retracted prior to or during the high-speed rotation of the drive shaft, with the retraction being to the distal counterweight, the abrasive element, the proximal counterweight, or beyond the proximal counterweight.

摘要翻译： 公开了一种用于研磨内腔（动脉）内部的阻塞（狭窄）的高速粥样斑块切除装置。 该装置使用快速旋转的驱动轴，其包括偏心研磨元件，该偏心研磨元件的质心横向偏离驱动轴的旋转轴线。 当驱动轴旋转时，离心力将偏心研磨元件向外驱动，使其以高于其静止直径的高旋转速度跟踪研磨直径。 驱动轴包括研磨元件的两侧的配重，其可以在高转速下稳定操作。 在一些情况下，配重也是偏心的，其质心中心与旋转轴线沿与研磨元件相反的方向横向偏移。 配重与研磨元件纵向分离，并且在一些情况下，分离是可调节的和/或可控制的。 在一些情况下，导丝可以在驱动轴的高速旋转之前或期间缩回，其中缩回是远端配重，研磨元件，近侧配重或超过近侧配重。

公开(公告)号：US5158080A

公开(公告)日：1992-10-27

申请号：US824308

申请日：1992-01-23

申请人： Michael J. Kallok

发明人： Michael J. Kallok

IPC分类号： A61N1/36

CPC分类号： A61N1/3601

摘要： An apparatus for and method of improving muscle tone of a patient using chronic sub-tetanic electrical stimulation. For patients suffering from obstructive sleep apnea, for example, the muscles of the upper airway are provided the chronic stimulation to mitigate or prevent the adverse medical condition caused in part by excessively flaccid muscle tissue around and in the airway.A stimulation generator supplies pulses to the muscle to be treated through insulated leads which are coupled to electrodes directly in contact with the appropriate neuro-muscular tissue. The output of the stimulation generator is adjusted to a frequency of sufficiently low level as to prevent fused tetanic contraction of the stimulated muscle. The adjustment may be made manually by attending medical personnel or may be done automatically using electrodes to sense the tension of the stimulated muscle. In the automatic mode, the sensing system insures the stimulation frequency level is decreased below the threshold of muscle tetanus.Stimulation may be accomplished at a particular site or may be multiplexed to a number of sites. Chronic stimulation will enhance muscle tone to an individual degree and then will simply maintain the desired status.

摘要翻译： 使用慢性亚急性电刺激改善患者肌肉紧张度的装置和方法。 例如，对于患有阻塞性睡眠呼吸暂停症的患者，为上呼吸道的肌肉提供慢性刺激以减轻或预防部分由气道周围和气道中过度松弛的肌肉组织引起的不良医学状况。 刺激发生器通过绝缘引线将脉冲提供给待治疗的肌肉，所述绝缘引线与直接与适当的神经 - 肌肉组织接触的电极耦合。 将刺激发生器的输出调节到足够低的水平的频率，以防止被刺激的肌肉的融合的强直性收缩。 可以通过参加医务人员手动进行调整，或者可以使用电极自动地进行调节，以感测被刺激的肌肉的张力。 在自动模式下，感应系统确保刺激频率水平降低到肌肉破伤风阈值以下。 刺激可以在特定部位完成，或者可以复用到多个部位。 慢性刺激会增强个人的肌肉紧张度，然后只会保持所需状态。

公开(公告)号：US5133354A

公开(公告)日：1992-07-28

申请号：US610854

申请日：1990-11-08

申请人： Michael J. Kallok

发明人： Michael J. Kallok

IPC分类号： A61N1/36

CPC分类号： A61N1/3601

摘要： An apparatus for and method of improving muscle tone of a patient using chronic sub-tetanic electrical stimulation. For patients suffering from obstructive sleep apnea, for example, the muscles of the upper airway are provided the chronic stimulation to mitigate or prevent the adverse medical condition caused in part by excessively flaccid muscle tissue around and in the airway.A stimulation generator supplies pulses to the muscle to be treated through insulated leads which are coupled to electrodes directly in contact with the appropriate neuro-muscular tissue. The output of the stimulation generator is adjusted to a frequency of sufficiently low level as to prevent fused tetanic contraction of the stimulated muscle. The adjustment may be made manually by attending medical personnel or may be done automatically using electrodes to sense the tension of the stimulated muscle. In the automatic mode, the sensing system insures the stimulation frequency level is decreased below the threshold of muscle tetanus.Stimulation may be accomplished at a particular site or may be mutliplexed to a number of sites. Chronic stimulation will enhance muscle tone to an individual degree and then will simply maintain the desired status.

摘要翻译： 使用慢性亚急性电刺激改善患者肌肉紧张度的装置和方法。 例如，对于患有阻塞性睡眠呼吸暂停症的患者，为上呼吸道的肌肉提供慢性刺激以减轻或预防部分由气道周围和气道中过度松弛的肌肉组织引起的不良医学状况。 刺激发生器通过绝缘引线将脉冲提供给待治疗的肌肉，所述绝缘引线与直接与适当的神经 - 肌肉组织接触的电极耦合。 将刺激发生器的输出调节到足够低的水平的频率，以防止被刺激的肌肉的融合的强直性收缩。 可以通过参加医务人员手动进行调整，或者可以使用电极自动地进行调节，以感测被刺激的肌肉的张力。 在自动模式下，感应系统确保刺激频率水平降低到肌肉破伤风阈值以下。 刺激可以在特定部位完成，或者可能被复合到多个部位。 慢性刺激会增强个人的肌肉紧张度，然后只会保持所需状态。

公开(公告)号：US5211173A

公开(公告)日：1993-05-18

申请号：US947826

申请日：1992-09-21

申请人： Michael J. Kallok ,  Brian B. Lee

发明人： Michael J. Kallok ,  Brian B. Lee

IPC分类号： A61N1/36

CPC分类号： A61N1/3601

摘要： A method of and apparatus for controlling one or more parameters of an electrical stimulation generator in response to measured results of the stimulation. In the preferred mode, this technique is employed in a system for the treatment of obstructive sleep apnea. Sensors are used to determine the effectiveness of the stimulation. Amplitude and pulse width are modified in response to the measurements from the sensors.

摘要翻译： 响应于刺激的测量结果控制电刺激发生器的一个或多个参数的方法和装置。 在优选模式中，该技术用于治疗阻塞性睡眠呼吸暂停的系统。 传感器用于确定刺激的有效性。 响应于传感器的测量，修改幅度和脉冲宽度。

公开(公告)号：US5174287A

公开(公告)日：1992-12-29

申请号：US706165

申请日：1991-05-28

申请人： Michael J. Kallok ,  H. Toby Markowitz

发明人： Michael J. Kallok ,  H. Toby Markowitz

IPC分类号： A61B5/08 ,  A61N1/36 ,  A61N1/365

CPC分类号： A61N1/3601

摘要： An improved apparatus for and method of providing feedback to an implantable pulse generator to treat obstructive sleep apnea. Sensors monitor the electrical activity associated with contractions of the diaphragm. The pressure within the thorax and the upper airway are also measured. Whenever electrical activity of the diaphragm suggests that an inspiration cycle is in progress and the pressure sensors show an abnormal pressure differential across the airway, the presence of obstructive sleep apenea is assumed and electrical stimulation is applied to the musculature of the upper airway.

摘要翻译： 一种用于向可植入脉冲发生器提供反馈以治疗阻塞性睡眠呼吸暂停的改进的装置和方法。 传感器监测与隔膜收缩相关的电活动。 也测量胸腔和上呼吸道内的压力。 无论何时隔膜的电活动表明启动循环正在进行，压力传感器显示气道两侧的异常压力差异，则假设存在阻塞性睡眠apenea，并且电刺激应用于上呼吸道的肌肉组织。

公开(公告)号：US4768523A

公开(公告)日：1988-09-06

申请号：US941994

申请日：1986-12-15

申请人： Patrick T. Cahalan ,  Allan H. Jevne ,  Arthur J. Coury ,  Michael J. Kallok

发明人： Patrick T. Cahalan ,  Allan H. Jevne ,  Arthur J. Coury ,  Michael J. Kallok

IPC分类号： A61N1/05 ,  C08J3/00 ,  C09J141/00

CPC分类号： C08J3/00 ,  A61N1/05 ,  C09J141/00 ,  C08J2333/26

摘要： An improved hydrogel adhesive, particularly adapted for adhesion and contact to tissue. It is especially useful in attaching electrical leads to tissue, for example in attaching pacemaker leads to the heart, interiorly or exteriorly.

摘要翻译： 改进的水凝胶粘合剂，特别适于粘附和接触组织。 将电引线附接到组织中是特别有用的，例如将心脏起搏器引线附接到内部或外部。