公开(公告)号：US08452356B2

公开(公告)日：2013-05-28

申请号：US12434640

申请日：2009-05-02

申请人： Michael J. Vestel ,  Karen M. Nashold ,  Joseph R. Stetter ,  Diane P. Walter ,  Gregory W. Faris ,  Christopher Holland ,  Roger Schmidt

发明人： Michael J. Vestel ,  Karen M. Nashold ,  Joseph R. Stetter ,  Diane P. Walter ,  Gregory W. Faris ,  Christopher Holland ,  Roger Schmidt

IPC分类号： A61B5/00

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6833 ,  A61B5/6849 ,  A61B2562/028

摘要： Optical microneedles are adapted for near-infrared or mid-infrared in vivo spectroscopic sensing; and provide a MEMS-based spectrometer for continuous lactate and glucose monitoring by means of a near-infrared or mid-infrared optical microneedle array in a transdermal patch.

摘要翻译： 光学微针适用于近红外或中红外体内光谱传感; 并且通过在透皮贴剂中的近红外或中红外光学微针阵列提供用于连续乳酸盐和葡萄糖监测的基于MEMS的光谱仪。

公开(公告)号：US20100121163A1

公开(公告)日：2010-05-13

申请号：US12434640

申请日：2009-05-02

申请人： Michael J. Vestel ,  Karen M. Nashold ,  Joseph R. Stetter ,  Diane P. Walter ,  Gregory W. Faris ,  Chistopher Holland ,  Roger Schmidt

发明人： Michael J. Vestel ,  Karen M. Nashold ,  Joseph R. Stetter ,  Diane P. Walter ,  Gregory W. Faris ,  Chistopher Holland ,  Roger Schmidt

IPC分类号： A61B6/08

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6833 ,  A61B5/6849 ,  A61B2562/028

摘要： Optical microneedles are adapted for near-infrared or mid-infrared in vivo spectroscopic sensing; and provide a MEMS-based spectrometer for continuous lactate and glucose monitoring by means of a near-infrared or mid-infrared optical microneedle array in a transdermal patch.

摘要翻译： 光学微针适用于近红外或中红外体内光谱传感; 并且通过在透皮贴剂中的近红外或中红外光学微针阵列提供用于连续乳酸盐和葡萄糖监测的基于MEMS的光谱仪。

公开(公告)号：US5280169A

公开(公告)日：1994-01-18

申请号：US995200

申请日：1992-12-22

申请人： Richard C. Honey ,  Robert A. Brown ,  Karen M. Nashold ,  Richard C. Adamo

发明人： Richard C. Honey ,  Robert A. Brown ,  Karen M. Nashold ,  Richard C. Adamo

IPC分类号： G02B5/23 ,  G02F1/17 ,  H01J3/14 ,  G02F1/01

CPC分类号： G02F1/17 ,  G02B5/23

摘要： Method and apparatus for limiting optical radiation to an optical sensor are disclosed for protecting the sensor against damage from high intensity optical radiation. A fixed electric field is established between a pair of spaced electrodes by connection of the electrodes to a DC voltage source. Small solid particles oscillate back and forth in the electric field between the electrodes. Incident optical radiation is focused at a focal plane at the oscillating solid particles, and energy transmitted through the oscillating particles is focused at the optical sensor. The transmittance of the particle-containing space is substantially constant for incident optical radiation intensity up to a threshold level below which the sensor is undamaged by the radiation. Above the threshold, oscillating particles are heated to a high temperature for vaporization, ionization and thermal expansion thereof for increased scatter and absorption thereby limiting optical radiation to the sensor to an intensity below which damage to the sensor occurs.

摘要翻译： 公开了用于将光辐射限制到光学传感器的方法和装置，用于保护传感器免受高强度光辐射的损害。 通过将电极连接到DC电压源，在一对间隔的电极之间建立固定的电场。 小固体颗粒在电极之间的电场中来回振荡。 入射光辐射聚焦在振荡固体颗粒的焦平面处，透过振荡粒子的能量聚焦在光学传感器处。 对于入射光辐射强度直到阈值水平以下，含有颗粒的空间的透射率基本上是恒定的，在该阈值水平以下，传感器不被辐射损坏。 高于阈值时，振荡颗粒被加热到高温以进行蒸发，电离和热膨胀，以增加散射和吸收，从而将光学辐射限制到传感器到低于传感器损坏的强度。