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公开(公告)号：US08450355B2
公开(公告)日：2013-05-28
申请号：US13120730
申请日：2009-09-22
申请人： Michael K. C. Wong , Wensheng Yu , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Joseph A. Kozlowski , Seong Heon Kim , Guowei Zhou , De-Yi Yang , Razia K. Rizvi , Lei Chen , Aneta Maria Kosinzki , Kristin E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
发明人： Michael K. C. Wong , Wensheng Yu , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Joseph A. Kozlowski , Seong Heon Kim , Guowei Zhou , De-Yi Yang , Razia K. Rizvi , Lei Chen , Aneta Maria Kosinzki , Kristin E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
IPC分类号： A61K31/4166 , A61K31/4178 , C07D233/02
CPC分类号： C07D405/14 , C07D403/06 , C07D403/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α combinations thereof.
摘要翻译： 本发明涉及如本文定义的式（I） - （IX）：或其药学上可接受的盐，溶剂合物或酯的化合物，其可用于治疗由MMP，ADAM，TACE介导的疾病或病症 ，聚集蛋白聚糖酶，其TNF-α组合。
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公开(公告)号：US08569336B2
公开(公告)日：2013-10-29
申请号：US13127953
申请日：2009-11-09
申请人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K. C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K. C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4166 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/506 , C07D233/76 , C07D213/24
CPC分类号： C07D498/04 , C07D513/00 , C07D519/00
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，其可用于治疗疾病或病症介导 通过MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合。
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公开(公告)号：US08541572B2
公开(公告)日：2013-09-24
申请号：US13127952
申请日：2009-11-09
申请人： Joseph A. Kozlowski , Wensheng Yu , Michael K. C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Joseph A. Kozlowski , Wensheng Yu , Michael K. C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： C07D295/03 , C07D241/20 , C07D211/30 , C07D213/46 , C07D403/06 , C07D203/16
CPC分类号： C07D403/14
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗 由MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合介导的疾病或病症。
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公开(公告)号：US08859529B2
公开(公告)日：2014-10-14
申请号：US13120728
申请日：2009-09-22
申请人： Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Ling Tong , Michael K. C. Wong , Brian J. Lavey , Joseph A. Kozlowski , Lei Chen , Razia K. Rizvi , Aneta Maria Kosinski , De-Yi Yang , Guowei Zhou , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
发明人： Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Ling Tong , Michael K. C. Wong , Brian J. Lavey , Joseph A. Kozlowski , Lei Chen , Razia K. Rizvi , Aneta Maria Kosinski , De-Yi Yang , Guowei Zhou , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
IPC分类号： C07D205/06 , C07D413/14 , C07D239/02 , C07D401/14 , C07F9/02 , C07D491/04 , C07D471/02 , C07D233/54 , C07D403/14 , A61K31/675 , A61K31/397 , A61K31/5377 , A61K31/497 , A61K31/505 , A61K31/4427 , A61K31/4155 , C07D405/14 , C07D403/06 , C07D491/048
CPC分类号： C07D403/14 , C07D403/06 , C07D405/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及本文所述的式（I）化合物或其药学上可接受的盐，溶剂化物或酯，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-或介导的疾病或病症 其组合。
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公开(公告)号：US20110288077A1
公开(公告)日：2011-11-24
申请号：US13120730
申请日：2009-09-22
申请人： Michael K.C. Wong , Wensheng Yu , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Joseph A. Kozlowski , Seong Heon Kim , Guowei Zhou , De-Yi Yang , Razia K. Rizvi , Lei Chen , Aneta Maria Kosinski , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
发明人： Michael K.C. Wong , Wensheng Yu , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Joseph A. Kozlowski , Seong Heon Kim , Guowei Zhou , De-Yi Yang , Razia K. Rizvi , Lei Chen , Aneta Maria Kosinski , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
IPC分类号： A61K31/4178 , C07D405/14 , C07D401/14 , C07D491/048 , A61K31/517 , A61K31/4355 , A61K31/4439 , A61K31/496 , A61K31/551 , A61P19/02 , A61P1/02 , A61P35/04 , A61P27/06 , A61P1/00 , A61P17/06 , A61P9/00 , A61P31/00 , A61P31/18 , C07D403/06
CPC分类号： C07D405/14 , C07D403/06 , C07D403/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α combinations thereof.
摘要翻译： 本发明涉及如本文定义的式（I） - （IX）：或其药学上可接受的盐，溶剂合物或酯的化合物，其可用于治疗由MMP，ADAM，TACE介导的疾病或病症 ，聚集蛋白聚糖酶，TNF-α组合。
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公开(公告)号：US20120015926A1
公开(公告)日：2012-01-19
申请号：US13127953
申请日：2009-11-09
申请人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K.C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Joseph A. Kozlowski , Michael K.C. Wong , Lei Chen , Guowei Zhou , Razia K. Rizvi , Robert Feltz , Aneta Maria Kosinski , De-Yi Yang , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4178 , C07D403/14 , C07D513/04 , C07D487/04 , C07D419/14 , C07D405/14 , C07D413/14 , A61K31/4355 , A61K31/429 , A61K31/519 , A61K31/427 , A61K31/433 , A61K31/506 , A61K31/496 , A61K31/5377 , A61P27/06 , A61P11/00 , A61P17/00 , A61P17/06 , A61P31/18 , A61P3/10 , A61P25/00 , A61P19/02 , A61P1/00 , A61P35/00 , C07D491/048
CPC分类号： C07D498/04 , C07D513/00 , C07D519/00
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，其可用于治疗疾病或病症介导 通过MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合。
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公开(公告)号：US20110288054A1
公开(公告)日：2011-11-24
申请号：US13120728
申请日：2009-09-22
申请人： Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Ling Tong , Michael K.C. Wong , Brian J. Lavey , Joseph A. Kozlowski , Lei Chen , Razia K. Rizvi , Aneta Maria Kosinski , De-Yi Yang , Guowei Zhou , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
发明人： Bandarpalle B. Shankar , Seong Heon Kim , Wensheng Yu , Ling Tong , Michael K.C. Wong , Brian J. Lavey , Joseph A. Kozlowski , Lei Chen , Razia K. Rizvi , Aneta Maria Kosinski , De-Yi Yang , Guowei Zhou , Kristen E. Rosner , Luke Fire , Judson E. Richard , Dansu Li
IPC分类号： A61K31/675 , A61K31/4355 , A61K31/5377 , A61K31/496 , C07F9/6561 , A61K31/4178 , C07D403/14 , C07D403/06 , A61K31/513 , C07D405/14 , A61K31/4741 , C07D401/14 , A61K31/4439 , A61P29/00 , C07D491/048
CPC分类号： C07D403/14 , C07D403/06 , C07D405/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译： 本发明涉及本文所述的式（I）化合物或其药学上可接受的盐，溶剂化物或酯，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-或介导的疾病或病症 其组合。
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公开(公告)号：US20120010181A1
公开(公告)日：2012-01-12
申请号：US13127952
申请日：2009-11-09
申请人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人： Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号： A61K31/4178 , C07D401/14 , C07D491/052 , C07D413/14 , C07D417/14 , C07D403/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/436 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P29/00 , A61P19/02 , A61P1/02 , A61P35/00 , A61P35/04 , A61P25/00 , A61P27/06 , A61P1/00 , A61P17/06 , A61P9/00 , A61P31/18 , A61P31/04 , C07D403/06
CPC分类号： C07D403/14
摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗 由MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合介导的疾病或病症。
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公开(公告)号：US20090156586A1
公开(公告)日：2009-06-18
申请号：US12364845
申请日：2009-02-03
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号： A61K31/4178 , C07D403/06 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D413/14 , A61K31/427 , A61K31/517 , A61K31/54 , A61K31/5377 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/506
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
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公开(公告)号：US07524842B2
公开(公告)日：2009-04-28
申请号：US11653511
申请日：2007-01-16
申请人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人： Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号： A61K31/428 , A61K31/4015 , A61K31/4166 , C07D209/04 , C07D233/24 , C07D277/34 , C07D417/06
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。
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