公开(公告)号：US20060074547A1

公开(公告)日：2006-04-06

申请号：US10955523

申请日：2004-09-30

申请人： Michael Kaufman ,  Christian Hecht

发明人： Michael Kaufman ,  Christian Hecht

IPC分类号： G01C21/36

CPC分类号： G06F17/30241 ,  G01C21/32 ,  Y10S707/99953 ,  Y10S707/99954

摘要： A method for operating a navigation system that executes a navigation application software program to provide a navigation-related feature is provided. The method comprises identifying that the navigation application software program uses both updated geographic data and un-updated geographic data from a geographic database associated with said navigation system. The un-updated geographic data has an associated date or version different from the updated geographic data. The method further comprises providing a report indicating that an inconsistency between the updated geographic data and the un-updated geographic data may exist. The method may further include identifying the inconsistency between the updated geographic data and the un-updated geographic data.

摘要翻译： 提供一种用于操作执行导航应用软件程序以提供导航相关特征的导航系统的方法。 该方法包括识别导航应用软件程序使用来自与所述导航系统相关联的地理数据库的更新的地理数据和未更新的地理数据。 未更新的地理数据具有与更新的地理数据不同的关联日期或版本。 该方法还包括提供指示可能存在更新的地理数据与未更新地理数据之间的不一致性的报告。 该方法还可以包括识别更新的地理数据与未更新的地理数据之间的不一致性。

公开(公告)号：US20060033341A1

公开(公告)日：2006-02-16

申请号：US10917448

申请日：2004-08-13

申请人： Michael Kaufman

发明人： Michael Kaufman

IPC分类号： F03B13/00 ,  H02P9/04

CPC分类号： F03B7/00 ,  F01C11/006 ,  F04C18/16 ,  F04C23/005 ,  F04C23/02 ,  F04D25/04 ,  Y02E10/223 ,  Y02P70/525

摘要： The waterwheel powered air delivery device is a system for powering an air compressor, aerator, or other device that moves air from power produced by a waterwheel without the necessity of providing electricity from an outside power source or the intermediate production of electricity from the waterwheel. The waterwheel may be an overshot, undershot or sideshot waterwheel. The device being powered may be an air compressor, aerator, or other air delivery device having an air pump that may be of the diaphragm, piston, rotary vane, rotary screw or other type. Preferably the air produced by the waterwheel and air delivery device is used for aeration of wastewater, although the delivery device may be used for other purposes, e.g., ventilation, power, etc.

摘要翻译： 水轮动力空气输送装置是用于为空气压缩机，曝气器或其他装置供电的系统，该装置从水轮产生的动力移动空气，而不需要从外部电源提供电力或从水轮中间产生电力。 水车可能是一个过冲，下面或侧面的水车。 被供电的装置可以是具有可以是隔膜，活塞，旋转叶片，旋转螺杆或其它类型的空气泵的空气压缩机，曝气器或其它空气输送装置。 优选地，由水车和空气输送装置产生的空气用于废水的通风，尽管输送装置可用于其它目的，例如通风，动力等。

公开(公告)号：US6031133A

公开(公告)日：2000-02-29

申请号：US21878

申请日：1998-02-11

申请人： Amos B. Smith, III ,  Yuping Qiu ,  Michael Kaufman ,  Hirokaza Arimoto ,  David R. Jones ,  Kaoru Kobayashi

发明人： Amos B. Smith, III ,  Yuping Qiu ,  Michael Kaufman ,  Hirokaza Arimoto ,  David R. Jones ,  Kaoru Kobayashi

IPC分类号： C07D303/16 ,  A61K31/047 ,  A61K31/12 ,  A61K31/27 ,  A61K31/336 ,  A61K31/351 ,  A61K31/366 ,  A61K31/422 ,  A61K31/427 ,  A61K31/5355 ,  A61K31/7028 ,  A61P35/00 ,  A61P37/06 ,  C07C239/06 ,  C07D263/22 ,  C07D309/10 ,  C07D309/30 ,  C07D309/32 ,  C07D319/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07F7/18 ,  C07H23/00 ,  C07C233/04

CPC分类号： C07D413/12 ,  C07C239/06 ,  C07D263/22 ,  C07D309/30 ,  C07D319/06 ,  C07F7/1892

摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

摘要翻译： 提供了含内酯化合物如脱氧胆甾醇的合成方法，以及模拟其化学和/或生物活性的化合物，以及可用于其制备的方法和中间体。

公开(公告)号：US08486124B2

公开(公告)日：2013-07-16

申请号：US11940852

申请日：2007-11-15

申请人： Steven Hendrix ,  Kenneth Oif ,  Michael Kaufman

发明人： Steven Hendrix ,  Kenneth Oif ,  Michael Kaufman

IPC分类号： A61N5/06

CPC分类号： A61N5/0616 ,  A61N2005/064 ,  A61N2005/0661

摘要： A phototherapy treatment dispensing device provides therapeutic light emissions treatments. The device provides additional means for controlling a patient's exposure to those treatments through a controlled protocol timer. The controlled protocol timer can provide for incremental exposure increases; monitors patient compliance with a treatment regimen; and reminds the patient when a treatment will soon be overdue.

摘要翻译： 光疗治疗分配装置提供治疗性光排放治疗。 该装置提供了通过受控协议定时器来控制患者对这些治疗的暴露的附加手段。 受控协议定时器可以提供增量曝光增加; 监测患者对治疗方案的依从性; 并提醒患者治疗即将过期。

公开(公告)号：US20050137263A1

公开(公告)日：2005-06-23

申请号：US11051142

申请日：2005-02-04

申请人： Gordon Rewcastle ,  Julie Spicer ,  Stephen Barrett ,  Michael Kaufman ,  Jared Milbank ,  Haile Tecle

发明人： Gordon Rewcastle ,  Julie Spicer ,  Stephen Barrett ,  Michael Kaufman ,  Jared Milbank ,  Haile Tecle

IPC分类号： A61P9/04 ,  A61K31/165 ,  A61K31/166 ,  A61K31/18 ,  A61K31/21 ,  A61K31/27 ,  A61K31/66 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C229/58 ,  C07C233/65 ,  C07C237/28 ,  C07C259/10 ,  C07C311/45 ,  C07C317/36 ,  C07C323/36 ,  C07C323/39

CPC分类号： C07C317/36 ,  C07C259/10 ,  C07C323/36 ,  Y10S514/825

摘要： The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

摘要翻译： 本发明涉及4-取代苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。

公开(公告)号：US5581241A

公开(公告)日：1996-12-03

申请号：US289659

申请日：1994-08-12

申请人： Michael Kaufman ,  Richard W. Thomas

发明人： Michael Kaufman ,  Richard W. Thomas

IPC分类号： G08B17/107 ,  G08B17/10

CPC分类号： G08B17/107 ,  G08B17/113

摘要： A smoke detector that operates on the principle of scattered light is disclosed that has the capability of an operating sensitivity that is tens of times greater than that of smoke detectors presently available. Plural light sources are used, their light rays directed radially toward the center of a cylindrical detector chamber having a mirrored wall that reflects light back toward the chamber's center, thereby to brightly illuminate a central detection zone. Scattered light from smoke in this zone is detectable by a photocell at right angles to the converging multiple light rays. To obtain highly improved stability of the light output that enables ultra-high sensitivity, the light sources are light-emitting diodes in series connection and they are driven by a very stable constant voltage source that also powers the photocell detector. This system gains impressive sensitivity while reducing nuisance alarms that have been a common problem regarding efforts to increase smoke detector sensitivity. Whereas the goal of this invention is to improve the public safety, improvements are presented in smoke collection also, whereby ambient air is quickly and efficiently brought to the detector cell itself using convection currents that are enhanced by the aerodynamic design of the housing surrounding the cell.

摘要翻译： 公开了以散射光原理工作的烟雾探测器，其具有比当前可用的烟雾探测器的操作灵敏度高几十倍的能力。 使用多个光源，它们的光线径向指向圆柱形检测器室的中心，该圆柱形检测器室具有将光反射回室的中心的镜面壁，从而明亮地照亮中央检测区。 在该区域内来自烟雾的散射光可以通过与会聚的多个光线成直角的光电池检测。 为了获得能够实现超高灵敏度的光输出的高度改进的稳定性，光源是串联连接的发光二极管，并且它们由也为光电池检测器供电的非常稳定的恒定电压源驱动。 该系统获得令人印象深刻的灵敏度，同时减少了增加烟雾探测器灵敏度方面常见问题的烦扰报警。 尽管本发明的目标是提高公共安全性，但是在烟气收集中也提出了改进，其中通过由围绕电池的壳体的空气动力学设计增强的对流电流将环境空气快速且有效地带到检测器单元本身 。

公开(公告)号：US20120292427A1

公开(公告)日：2012-11-22

申请号：US13440532

申请日：2012-04-05

申请人： Michael Kaufman ,  Rolando Antonio ,  Jeffrey Hochleutner ,  Dennis Miller

发明人： Michael Kaufman ,  Rolando Antonio ,  Jeffrey Hochleutner ,  Dennis Miller

IPC分类号： B65H16/02

CPC分类号： B65D85/671 ,  Y02W90/14

摘要： Various embodiments of the present disclosure provide a combination strapping package and dispenser that includes a first strapping coil holding compartment and a second strapping coil holding compartment configured to be nested together and to define a coil receiving or holding area. The combination strapping package and dispenser is configured to hold a strapping coil during shipment from the manufacturer or distributor to the end user and additionally during the use of the strapping by the end user such that the end user does not need to remove the strapping coil from the combination strapping package and dispenser. In certain embodiments, the combination strapping package and dispenser of the present disclosure is configured for mid-range amounts of coil which are easier to transport and use, is compostable, and requires less cost to ship.

摘要翻译： 本公开的各种实施例提供了一种组合捆扎包装和分配器，其包括第一捆扎线圈保持隔间和第二捆扎线圈保持隔间，其构造成嵌套在一起并限定线圈接收或保持区域。 组合捆扎包装和分配器被配置为在从制造商或分销商运送到最终用户期间保持捆扎线圈，并且另外在由最终用户使用捆扎带期间，使得最终用户不需要将捆扎线圈从 组合包装和分配器。 在某些实施例中，本公开的组合捆扎包装和分配器被配置为容易运输和使用的中等量的线圈，是可堆肥的，并且需要更少的运输成本。

公开(公告)号：US20080114006A1

公开(公告)日：2008-05-15

申请号：US11854354

申请日：2007-09-12

申请人： Daniel Flynn ,  Peter Petillo ,  Michael Kaufman ,  William Patt

发明人： Daniel Flynn ,  Peter Petillo ,  Michael Kaufman ,  William Patt

IPC分类号： A61K31/519 ,  A61K31/4375 ,  A61P1/00 ,  A61P11/00 ,  A61P17/06 ,  A61P19/02 ,  A61P35/00 ,  A61P37/00 ,  A61P9/00 ,  C07D401/04 ,  C07D471/04 ,  C12N9/12

CPC分类号： A61K31/4375 ,  A61K31/519 ,  C07D471/04

摘要： The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

摘要翻译： 本发明涉及可用于治疗各种疾病的新型激酶抑制剂和调节剂化合物。 更具体地，本发明涉及这些化合物，激酶/化合物加合物，治疗疾病的方法和化合物的合成方法。 优选地，所述化合物可用于调节Raf激酶及其疾病多形体的激酶活性。 本发明的化合物可用于治疗哺乳动物癌症，特别是人类癌症，包括但不限于恶性黑素瘤，结肠直肠癌，卵巢癌，甲状腺乳头状癌，非小细胞肺癌和间皮瘤。 本发明的化合物还可用于治疗类风湿性关节炎和视网膜病变，包括糖尿病性视网膜神经病变和黄斑变性。

公开(公告)号：US20060172225A1

公开(公告)日：2006-08-03

申请号：US11294816

申请日：2005-12-06

申请人： Joan Mintz ,  Michael Kaufman ,  Norman Jessiman

发明人： Joan Mintz ,  Michael Kaufman ,  Norman Jessiman

IPC分类号： G03C1/76

CPC分类号： G03F7/0045 ,  G03F7/0048 ,  G03F7/0382 ,  G03F7/0392

摘要： Photoresists of the invention contain an added acid reaction component together with one or more resins and a photoactive component. Preferred photoresists of the invention can provide processes substrates such as microelectronic wafers with desired iso-dense bias values. Particularly preferred photoresists of the invention are chemically-amplified positive-acting resists and contain an ester-based solvent such as ethyl lactate or propylene glycol methyl ether acetate in addition to the acid reaction component.

公开(公告)号：US20060089798A1

公开(公告)日：2006-04-27

申请号：US10975030

申请日：2004-10-27

申请人： Michael Kaufman ,  James Herbst ,  Steven Devries ,  Eric Groth

发明人： Michael Kaufman ,  James Herbst ,  Steven Devries ,  Eric Groth

IPC分类号： G01C21/30

CPC分类号： G01C21/3635

摘要： A system and method are disclosed for displaying map information on a computing device. Data are stored for rendering a simulation of travel along one or more road segments prior to embarking on travel along the road segments. The simulation is comprised of a sequence of views of the road network along each road segment from vantage points above or along the road network. Each road segment may be part of a calculated route and the simulation may include views for all the road segments contained in the calculated route. While the computing device is being conveyed along each road segment, the data stored for the simulation is used to show a view of the road network that includes the current position of the computing device on a display of the computing device.

摘要翻译： 公开了一种用于在计算设备上显示地图信息的系统和方法。 存储数据用于在沿着路段行驶之前沿着一个或多个路段进行旅行的模拟。 该模拟由沿着道路网络上方或沿着道路网络的有利位置的沿着每条路段的道路网络的视图序列组成。 每个路段可以是计算的路线的一部分，并且模拟可以包括包含在所计算的路线中的所有道路段的视图。 当沿着每个路段传送计算设备时，为模拟而存储的数据用于显示包括计算设备在计算设备的显示器上的当前位置的道路网络的视图。