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公开(公告)号：US06586222B1
公开(公告)日：2003-07-01
申请号：US08395456
申请日：1995-02-28
IPC分类号： C12N950
CPC分类号： C12N9/6424 , A61K38/00 , C07K5/06191 , C07K14/525 , C07K14/811 , C07K16/40 , C12N9/50 , C12N9/99 , C12Q1/37 , G01N2333/525
摘要： Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is useful for discovering inhibitors of excessive release of mature, active TNF&agr;. Also disclosed are methods for the identification of inhibitors of the conversion of the pro-form of TNF&agr; to its mature active form.
摘要翻译： 公开了通过活化本文称为proPR-3的原型的纯化的活性重组人嗜中性粒细胞蛋白酶PR-3的方法和材料。 人类PR-3可用于发现过度释放成熟的活性TNFα的抑制剂。 还公开了用于鉴定TNFα前体转化成其成熟活性形式的抑制剂的方法。
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公开(公告)号：US06599706B1
公开(公告)日：2003-07-29
申请号：US08487453
申请日：1995-06-07
申请人： Robert F. Halenbeck , Michael Kriegler , Jan Tuttleman , Carl Perez , David A. Jewell , Kirston E. Koths
发明人： Robert F. Halenbeck , Michael Kriegler , Jan Tuttleman , Carl Perez , David A. Jewell , Kirston E. Koths
IPC分类号： G01N3353
CPC分类号： C12N9/6424 , A61K38/00 , C07K5/06191 , C07K14/525 , C07K14/811 , C07K16/40 , C12Q1/37 , G01N2333/525 , Y02A50/411
摘要： Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is useful for discovering inhibitors of excessive release of mature, active TNF&agr;. Also disclosed are methods for the identification of inhibitors of the conversion of the pro-form of TNF&agr; to its mature active form.
摘要翻译： 公开了通过活化本文称为proPR-3的原型的纯化的活性重组人嗜中性粒细胞蛋白酶PR-3的方法和材料。 人类PR-3可用于发现过度释放成熟的活性TNFα的抑制剂。 还公开了用于鉴定TNFα前体转化成其成熟活性形式的抑制剂的方法。
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3.发明授权
公开(公告)号：US5998378A
公开(公告)日：1999-12-07
申请号：US230428
申请日：1994-04-19
IPC分类号： A61K38/00 , C07K5/06 , C07K14/525 , C07K14/81 , C07K16/40 , C12N9/50 , C12N9/64 , C12N9/99 , C12Q1/37
CPC分类号： C12N9/6424 , C07K14/525 , C07K14/811 , C07K16/40 , C07K5/06191 , C12N9/50 , C12N9/99 , C12Q1/37 , A61K38/00 , G01N2333/525
摘要： Compounds having proteolytic inhibitory activity useful for treating diseases, particularly as applied to the treatment of sepsis, AIDS or autoimmune diseases, resulting from a decrease in the circulating level of mature protein hormones derived from the proteolytic cleavage of prohormone precursors such as 26 kDProTNF, and methods for identifying compounds having the desired inhibitory activity are provided.
摘要翻译： 具有蛋白水解抑制活性的化合物，可用于治疗疾病，特别是用于治疗败血症，AIDS或自身免疫性疾病的疾病，其是由衍生自激素原体如26kDProTNF的蛋白水解切割的成熟蛋白激素的循环水平降低而引起的，以及 提供了鉴定具有所需抑制活性的化合物的方法。
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公开(公告)号：US5843693A
公开(公告)日：1998-12-01
申请号：US394600
申请日：1995-02-27
IPC分类号： A61K38/00 , C07K5/06 , C07K14/525 , C07K14/81 , C07K16/40 , C12N9/50 , C12N9/64 , C12N9/99 , C12Q1/37
CPC分类号： C07K14/811 , C07K14/525 , C07K16/40 , C07K5/06191 , C12N9/50 , C12N9/6424 , C12N9/99 , C12Q1/37 , A61K38/00 , G01N2333/525 , Y10S436/811
摘要： Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is useful for discovering inhibitors of excessive release of mature, active TNF.alpha.. Also disclosed are methods for the identification of inhibitors of the conversion of the pro-form of TNF.alpha. to its mature active form.
摘要翻译： 公开了通过活化本文称为proPR-3的原型的纯化的活性重组人嗜中性粒细胞蛋白酶PR-3的方法和材料。 人类PR-3可用于发现过度释放成熟的活性TNFα的抑制剂。 还公开了用于鉴定TNFα形式转化成其成熟活性形式的抑制剂的方法。
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5.发明授权N.gradient.2-CSF-1(long form) and carboxy truncated fragments thereof 失效N NABLA 2-CSF-1（长形式）及其羧基截短的片段
公开(公告)号：US06117422A
公开(公告)日：2000-09-12
申请号：US425876
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle A. Noble , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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公开(公告)号：US5736340A
公开(公告)日：1998-04-07
申请号：US473791
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K38/36 , A61K39/395 , A61K49/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P37/00 , C07K1/18 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/574
CPC分类号： C07K14/70546 , C07K14/705 , A61K38/00 , C07K2319/00 , Y10S436/813
摘要： A purified glycoprotein complex of over 1200 kD apparent native molecular weight having a sedimentation value of approximately 25S and having the ability to selectively bind human Mac-2 or interfere with PHA activation of lymphocytes, DNA sequences that encode the protein, and expression systems for expressing it, thus providing for reagents that are useful for treating or diagnosing diseases, including cancer, infectious disease, and diseases of the immune system, and for monitoring the concentration of the glycoprotein in human milk.
摘要翻译： 具有超过1200kD表观天然分子量的纯化糖蛋白复合物，其沉降值为约25S，并且具有选择性结合人Mac-2或干扰淋巴细胞的PHA活化的能力，编码蛋白质的DNA序列和用于表达的表达系统 从而提供可用于治疗或诊断疾病（包括癌症，感染性疾病和免疫系统疾病）的试剂，并且用于监测人乳中糖蛋白的浓度。
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公开(公告)号：US5644035A
公开(公告)日：1997-07-01
申请号：US477674
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K38/36 , A61K39/395 , A61K49/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P37/00 , C07K1/18 , C07K1/20 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/574 , C07K1/00 , B01D15/08
CPC分类号： C07K14/70546 , C07K14/705 , A61K38/00 , C07K2319/00 , Y10S436/813
摘要： A purified glycoprotein complex of over 1200 kD apparent native molecular weight having a sedimentation value of approximately 25S and having the ability to selectively bind human Mac-2 or interfere with PHA activation of lymphocytes, DNA sequences that encode the protein, and expression systems for expressing it, thus providing for medicaments that are useful for treating or diagnosing diseases, including cancer, infectious disease, and diseases of the immune system.
摘要翻译： 具有超过1200kD表观天然分子量的纯化糖蛋白复合物，其沉降值为约25S，并且具有选择性结合人Mac-2或干扰淋巴细胞的PHA活化的能力，编码蛋白质的DNA序列和用于表达的表达系统 从而提供可用于治疗或诊断包括癌症，感染性疾病和免疫系统疾病在内的疾病的药物。
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8.发明授权N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof 失效N NABLA 2 CSF-1（短型）及其羧基截短的片段
公开(公告)号：US6103224A
公开(公告)日：2000-08-15
申请号：US426570
申请日：1995-04-21
申请人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
发明人： Martha B. Ladner , Janelle N. Van Arsdell , George A. Martin , Ernest S. Kawasaki , Mazie Yee Coyne , Robert F. Halenbeck , Kirston E. Koths
CPC分类号： C07K14/53 , C12N15/73 , A61K38/00 , Y10S930/14
摘要： A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both "long" and "short" forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.
摘要翻译： 集落刺激因子CSF-1是可用于调节免疫系统的淋巴因子。 是用于克服化疗诱导的免疫抑制或由其它原因引起的淋巴因子。 通过重组方法获得可用量的CSF-1，包括克隆和表达编码该蛋白质的鼠和人DNA序列。 公开了这种蛋白质的“长”和“短”形式和对应于cDNA编码形式的突变蛋白。
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公开(公告)号：USRE35171E
公开(公告)日：1996-03-05
申请号：US227651
申请日：1994-04-14
CPC分类号： C07K16/30 , C07K14/4706 , G01N33/5011 , G01N33/573 , Y10S530/828
摘要： Compositions useful for detecting ras gene proteins are described consisting of GTP and a protein having an apparent reduced molecular weight of about 115,000-120,000 daltons, or fragments derived therefrom, that stimulate ras protein guanosine triphosphatase activity. Also described are methods whereby the compositions are used to identify cancer therapeutics.
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10.发明授权
公开(公告)号：US5234839A
公开(公告)日：1993-08-10
申请号：US672348
申请日：1991-03-20
IPC分类号： C07K14/47 , C07K16/30 , G01N33/50 , G01N33/573
CPC分类号： G01N33/5011 , C07K14/4706 , C07K16/30 , G01N33/573 , Y10S436/813 , Y10S530/828
摘要： Compositions useful for detecting ras gene proteins are described consisting of GTP and a protein having an apparent reduced molecular weight of about 115,000-120,000 daltons, or fragments derived therefrom, that stimulate ras protein guanosine triphosphatase activity. Also described are methods whereby the compositions are used to identify cancer therapeutics.
摘要翻译： 描述了可用于检测ras基因蛋白质的组合物，其由GTP和具有约115,000-120,000道尔顿表观降低的分子量的蛋白质或其衍生的片段组成，其刺激ras蛋白质鸟苷三磷酸酶活性。 还描述了使用组合物来鉴定癌症治疗剂的方法。
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