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    DEVICES FOR MODIFICATION OF AIRWAYS BY TRANSFER OF ENERGY
    2.
    发明申请
    DEVICES FOR MODIFICATION OF AIRWAYS BY TRANSFER OF ENERGY 审中-公开
    通过能源转移修改航空的装置

    公开(公告)号：US20070118184A1

    公开(公告)日：2007-05-24

    申请号：US11614914

    申请日：2006-12-21

    申请人： Christopher DANEK ,  Bryan Loomas ,  Michael Biggs ,  Keith Burger ,  Dave Haugaard ,  Thomas Keast ,  John Ross ,  Michael Laufer

    发明人： Christopher DANEK ,  Bryan Loomas ,  Michael Biggs ,  Keith Burger ,  Dave Haugaard ,  Thomas Keast ,  John Ross ,  Michael Laufer

    IPC分类号： A61N1/00

    CPC分类号： A61B18/1492 ,  A61B18/08 ,  A61B18/1477 ,  A61B2017/00084 ,  A61B2017/00123 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00541 ,  A61B2018/00791 ,  A61B2018/00982 ,  A61B2018/046 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2018/1497 ,  A61B2090/3614 ,  A61N1/06 ,  A61N1/403 ,  A61N5/00

    摘要： This relates to methods and devices for treating reversible chronic obstructive pulmonary disease, and more particularly, relates to a device for exchanging energy with airway tissue such as that found in the airway of human lungs. The exchange of energy with this airway tissue in the airways reduces the ability of the air ways to constrict and/or reduces the resistance within the airway to the flow of air through the airway. This also relates to a method for decreasing responsiveness or decreasing resistance to airflow of airways involves the transfer of energy to or from the airway walls to prevent or reduce airway constriction and other symptoms of lung diseases. The treatment reduces the ability of the airway to contract during an acute narrowing of the airways, reduces mucus plugging of the airways, and/or increases the airway diameter. The methods according to the present invention provide a longer duration and/or more effective treatment for lung diseases than currently used drug treatments, and obviate patient compliance issues. This also includes additional steps that reduce the ability of the lung to produce at least one of the symptoms of reversible obstructive pulmonary disease and to reduce the resistance to the flow of air through a lung.

    摘要翻译： 这涉及用于治疗可逆性慢性阻塞性肺疾病的方法和装置，更具体地涉及用于与例如人肺气道中发现的气道组织交换能量的装置。 与气道中的这种气道组织的能量交换降低了气道收缩和/或降低气道内通过气道的空气流动的阻力的能力。 这也涉及一种降低呼吸道反应性或降低气道阻力的方法，涉及将气体转移到气道壁或从呼吸道壁传递能量，以防止或减少气道收缩和肺部疾病的其他症状。 该治疗降低了在气道急性变窄期间气道收缩的能力，减少气道的粘液堵塞和/或增加气道直径。 根据本发明的方法提供比目前使用的药物治疗更长的持续时间和/或更有效的肺部疾病治疗，并且消除患者依从性问题。 这还包括额外的步骤，其降低肺产生可逆性阻塞性肺疾病的至少一种症状的能力并降低对通过肺的空气流动的抵抗力。

    MODIFICATION OF AIRWAYS BY APPLICATION OF ENERGY
    3.
    发明申请
    MODIFICATION OF AIRWAYS BY APPLICATION OF ENERGY 有权
    通过应用能源对航空的修改

    公开(公告)号：US20070100390A1

    公开(公告)日：2007-05-03

    申请号：US11534621

    申请日：2006-09-22

    申请人： Christopher Danaek ,  Michael Biggs ,  Keith Burger ,  Bryan Loomas ,  Thomas Keast ,  Dave Haugaard

    发明人： Christopher Danaek ,  Michael Biggs ,  Keith Burger ,  Bryan Loomas ,  Thomas Keast ,  Dave Haugaard

    IPC分类号： A61N1/18

    CPC分类号： A61B18/1492 ,  A61B18/08 ,  A61B18/1477 ,  A61B2017/00084 ,  A61B2017/00123 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00541 ,  A61B2018/00791 ,  A61B2018/00982 ,  A61B2018/046 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2018/1497 ,  A61B2090/3614 ,  A61N1/06 ,  A61N1/403 ,  A61N5/00

    摘要： This relates to methods and devices for treating reversible chronic obstructive pulmonary disease, and more particularly, relates to a device for exchanging energy with airway tissue such as that found in the airway of human lungs. The exchange of energy with this airway tissue in the airways reduces the ability of the air ways to constrict and/or reduces the resistance within the airway to the flow of air through the airway. This also relates to a method for decreasing responsiveness or decreasing resistance to airflow of airways involves the transfer of energy to or from the airway walls to prevent or reduce airway constriction and other symptoms of lung diseases. The treatment reduces the ability of the airway Lo contract during an acute narrowing of the airways, reduces mucus plugging of the airways, and/or increases the airway diameter. The methods according to the present invention provide a longer duration and/or more effective treatment for lung diseases than currently used drug treatments, and obviate patient compliance issues. This also includes additional steps that reduce the ability of the lung to produce at least one of the symptoms of reversible obstructive pulmonary disease and to reduce the resistance to the flow of air through a lung.

    摘要翻译： 这涉及用于治疗可逆性慢性阻塞性肺疾病的方法和装置，更具体地涉及用于与例如人肺气道中发现的气道组织交换能量的装置。 与气道中的这种气道组织的能量交换降低了气道收缩和/或降低气道内通过气道的空气流动的阻力的能力。 这也涉及一种降低呼吸道反应性或降低气道阻力的方法，涉及将气体转移到气道壁或从气道壁传递，以防止或减少气道收缩和其他肺部疾病症状。 治疗降低了气道急性收缩期间气道Lo收缩的能力，减少气道的粘液堵塞和/或增加气道直径。 根据本发明的方法提供比目前使用的药物治疗更长的持续时间和/或更有效的肺部疾病治疗，并且消除患者依从性问题。 这还包括额外的步骤，其降低肺产生可逆性阻塞性肺疾病的至少一种症状的能力并降低对通过肺的空气流动的抵抗力。

    STEERABLE AND CURVABLE VERTEBROPLASTY SYSTEM WITH CLOG-RESISTANT EXIT PORTS
    4.
    发明申请
    STEERABLE AND CURVABLE VERTEBROPLASTY SYSTEM WITH CLOG-RESISTANT EXIT PORTS 审中-公开
    具有耐高温出口口的可转动和可弯曲的VERTEBROPLASTY系统

    公开(公告)号：US20120158004A1

    公开(公告)日：2012-06-21

    申请号：US13182335

    申请日：2011-07-13

    申请人： Keith Burger ,  Joshua Cheatwood ,  Shixin Chen

    发明人： Keith Burger ,  Joshua Cheatwood ,  Shixin Chen

    IPC分类号： A61B17/88

    CPC分类号： A61B17/8811 ,  A61B17/8827

    摘要： Methods and devices for augmenting bone, such as in performing vertebroplasty are disclosed. A bone cement injection needle is provided, having a laterally deflectable distal end. The distal end may be provided with one or two or more cavity creation elements, such as a bevel or diamond tip or inflatable balloons. A cavity creation element may include one or more filament layers. Systems are also disclosed, including the steerable and curvable injection needle, introducer and stylet. The system can also include various exit ports that can be configured with clog-resistant features. Methods are also disclosed.

    摘要翻译： 公开了用于增加骨骼的方法和装置，例如执行椎体成形术。 提供骨粘固剂注射针，其具有可横向偏转的远端。 远端可以设置有一个或两个或更多个空腔创建元件，例如斜面或金刚石尖端或可充气气球。 空腔产生元件可以包括一个或多个细丝层。 还公开了系统，包括可转向和可调节的注射针，导引器和探针。 该系统还可以包括可配置防堵塞功能的各种出口。 还公开了方法。

    Dermal and Transdermal Cryogenic Microprobe Systems and Methods
    5.
    发明申请
    Dermal and Transdermal Cryogenic Microprobe Systems and Methods 有权
    皮肤和透皮低温微探针系统和方法

    公开(公告)号：US20080154254A1

    公开(公告)日：2008-06-26

    申请号：US11614887

    申请日：2006-12-21

    申请人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

    发明人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/00747 ,  A61B2018/00452 ,  A61B2018/0262 ,  A61B2018/0293

    摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.

    摘要翻译： 医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。 实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。 治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量 冷却液。 可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

    Pain management using cryogenic remodeling
    6.
    发明授权
    Pain management using cryogenic remodeling 有权
    疼痛管理采用低温重塑

    公开(公告)号：US08715275B2

    公开(公告)日：2014-05-06

    申请号：US13615059

    申请日：2012-09-13

    申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

    发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

    IPC分类号： A61B18/18

    CPC分类号： A61F7/12 ,  A61B18/0218 ,  A61B2018/00452 ,  A61B2018/0293 ,  A61F7/00 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0087 ,  A61F2007/0094 ,  A61F2007/0285 ,  A61F2007/126

    摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

    摘要翻译： 用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。 替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。 在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

    Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling
    7.
    发明申请
    Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling 有权
    用于皮肤和透皮低温重塑的可更换和/或易于移除的针系统

    公开(公告)号：US20080200910A1

    公开(公告)日：2008-08-21

    申请号：US11675886

    申请日：2007-02-16

    申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

    发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

    IPC分类号： A61B18/02 ,  A61M5/31

    CPC分类号： A61B18/0218 ,  A61B18/02 ,  A61B2017/00747 ,  A61B2018/00023 ,  A61B2018/00458 ,  A61B2018/0262 ,  A61B2018/0293

    摘要： The present invention generally provides improved medical devices, systems, and methods. Embodiments may be particularly well suited for the treatment of dermatological and/or cosmetic defects, and alternative embodiments may be configured for treatment of a wide range of target tissues. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Unlike the large format cryogenic cooling systems of the past, small cryogenic cooling needle probes may dull or be damaged by insertion. Careful control over the control of cryogenic cooling fluid into a needle probe can allow the length of the active cooling to be controlled through depletion of liquid from an evaporating cryogenic cooling flow. Hence, even needles having similar external structures may provide differing lengths of an iceball along the needle axis. Surprisingly, small cryogenic cooling needles and/or other cryogenic cooling probes having a lubricious coating will allow safe removal of the probe from the treatment region while at a least a portion of the tissue remains frozen, significantly decreasing the overall time for a procedure involving many insertion/freeze/removal cycles.

    摘要翻译： 本发明通常提供改进的医疗装置，系统和方法。 实施方案可以特别适用于治疗皮肤病和/或美容缺陷，并且替代实施方案可以被配置用于治疗大范围的靶组织。 本发明的一些实施方案用至少一个小的穿透组织的探针进行冷却，所述探针通常包括适于穿过患者皮肤的暴露表面插入的尺寸的针，而不留下可见的瘢痕。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 示例性实施例使用由探针主体手柄支撑的可替换的针探针，在单个患者的治疗期间经常更换小的针头探针。 与过去的大型低温冷却系统不同，小型低温冷却针探针可能会沉没或被插入而损坏。 将低温冷却液控制到针头探针中的仔细控制可以通过从蒸发的低温冷却流中消耗液体来控制主动冷却的长度。 因此，即使具有相似外部结构的针也可以沿针轴提供不同长度的冰球。 令人惊讶的是，具有光滑涂层的小型低温冷却针和/或其它低温冷却探针将允许从处理区域安全地移除探针，同时在组织的至少一部分保持冷冻，显着降低涉及许多方法的程序的总体时间 插入/冻结/去除循环。

    Pain management using cryogenic remodeling
    9.
    发明申请
    Pain management using cryogenic remodeling 有权
    疼痛管理采用低温重塑

    公开(公告)号：US20090248001A1

    公开(公告)日：2009-10-01

    申请号：US12271013

    申请日：2008-11-14

    申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

    发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

    IPC分类号： A61B18/02

    CPC分类号： A61F7/12 ,  A61B18/0218 ,  A61B2018/00452 ,  A61B2018/0293 ,  A61F7/00 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0087 ,  A61F2007/0094 ,  A61F2007/0285 ,  A61F2007/126

    摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

    摘要翻译： 用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。 替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。 在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

    Dermal and transdermal cryogenic microprobe systems
    10.
    发明授权
    Dermal and transdermal cryogenic microprobe systems 有权
    皮肤和透皮低温微探针系统

    公开(公告)号：US09254162B2

    公开(公告)日：2016-02-09

    申请号：US11614887

    申请日：2006-12-21

    申请人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

    发明人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

    IPC分类号： A61B18/02 ,  A61B17/00 ,  A61B18/00

    CPC分类号： A61B18/02 ,  A61B2017/00747 ,  A61B2018/00452 ,  A61B2018/0262 ,  A61B2018/0293

    摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.

    摘要翻译： 医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。 实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。 治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量 冷却液。 可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。