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公开(公告)号：US09890128B2
公开(公告)日：2018-02-13
申请号：US15102417
申请日：2014-12-08
申请人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
发明人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
IPC分类号： C07D239/84 , B01J31/02 , C07D295/125
CPC分类号： C07D239/84 , B01J31/0202 , B01J31/0232 , B01J31/0244 , B01J31/0271 , B01J2231/324 , C07D295/125
摘要： The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
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公开(公告)号：US20160311781A1
公开(公告)日：2016-10-27
申请号：US15102417
申请日：2014-12-08
申请人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
发明人： Michael Luzung , Guy Humphrey , Bangping Xiang , Kevin M. Belyk , Stephen Mark Dalby , Wilfried Schwab , Burkhard Klenke , Tom Moody , Gareth Brown
IPC分类号： C07D239/84 , B01J31/02
CPC分类号： C07D239/84 , B01J31/0202 , B01J31/0232 , B01J31/0244 , B01J31/0271 , B01J2231/324 , C07D295/125
摘要： The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
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公开(公告)号：US20180179223A1
公开(公告)日：2018-06-28
申请号：US15578777
申请日：2016-06-03
申请人： Jingjun Yin , Tetsuji Itoh , Jianguo Yin , Bangping Xiang , Kevin R. Campos , Alexei Kalinin , Zhuqing Liu , Melodie Deniz Christensen , Kevin M. Belyk , Richard J. Varsolona , Andrew Brunskill
发明人： Jingjun Yin , Tetsuji Itoh , Jianguo Yin , Bangping Xiang , Kevin R. Campos , Alexei Kalinin , Zhuqing Liu , Melodie Deniz Christensen , Kevin M. Belyk , Richard J. Varsolona , Andrew Brunskill
IPC分类号： C07D498/04 , C07F5/02 , C07D403/04 , B01J31/04
CPC分类号： C07D498/04 , B01J31/04 , C07D403/04 , C07F5/025
摘要： The present invention is directed to processes for preparing Substituted Tetracyclic Heterocycle Compounds of formula (I): (I) which may be useful as HCV NS5A inhibitors. The present invention is also directed to compounds that may be useful as synthetic intermediates and catalysts in the processes of the invention.
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公开(公告)号：US20130274463A1
公开(公告)日：2013-10-17
申请号：US13993541
申请日：2011-12-13
申请人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
发明人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
IPC分类号： C07D498/16 , C07D209/44 , C07C271/56 , C07C309/85 , C07C311/47 , C07D403/12 , C07C309/80
CPC分类号： C07D498/16 , C07C271/22 , C07C271/24 , C07C271/56 , C07C309/80 , C07C309/85 , C07C311/47 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D209/44 , C07D403/12 , C07D498/18 , C07K5/06034
摘要： The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要翻译： 本发明涉及大分子内酰胺化合物，可用于制备大内酰胺的中间体，制备中间体的方法以及制备和改性大环内酯的方法。 本文所述的化合物和方法的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 可以使用本文所述方法合成的HCV抑制化合物的实例是化合物A及其衍生物。
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公开(公告)号：US09120818B2
公开(公告)日：2015-09-01
申请号：US13993541
申请日：2011-12-13
申请人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
发明人： Cheng Chen , Jongrock Kong , Guy Humphrey , Sarah Dolman , Hongmei Li , Matthew T. Tudge , Kelvin Yong , Bangping Xiang , Michael Zacuto
IPC分类号： C07D207/02 , C07D403/12 , C07D498/16 , C07C271/22 , C07C271/24 , C07C309/80 , C07C309/85 , C07C311/51 , C07D207/16 , C07D498/18 , C07D209/44 , C07K5/062 , C07C271/56 , C07C311/47
CPC分类号： C07D498/16 , C07C271/22 , C07C271/24 , C07C271/56 , C07C309/80 , C07C309/85 , C07C311/47 , C07C311/51 , C07C2601/02 , C07D207/16 , C07D209/44 , C07D403/12 , C07D498/18 , C07K5/06034
摘要： The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要翻译： 本发明涉及大分子内酰胺化合物，可用于制备大内酰胺的中间体，制备中间体的方法以及制备和改性大环内酯的方法。 本文所述的化合物和方法的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 可以使用本文所述方法合成的HCV抑制化合物的实例是化合物A及其衍生物。
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公开(公告)号：US20100279986A1
公开(公告)日：2010-11-04
申请号：US12834283
申请日：2010-07-12
申请人： Yue-Mei ZHANG , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
发明人： Yue-Mei ZHANG , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
IPC分类号： A61K31/55 , A61K31/635 , A61K31/4412 , A61K31/5377 , A61K31/45 , A61K31/4436 , A61K31/551 , A61K31/541 , A61P9/00 , A61P9/14 , A61P35/00 , A61P29/00 , A61P25/00 , A61P25/28 , A61P25/14 , A61P19/02 , A61P1/04
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译： 本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。 本发明还提供了使用本发明的药物组合物的治疗和预防方法。
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公开(公告)号：US07803793B2
公开(公告)日：2010-09-28
申请号：US11858972
申请日：2007-09-21
申请人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
发明人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence J. Wilson , Prabha Karnachi
IPC分类号： C07D225/02 , C07D401/06 , C07D401/12 , C07D409/12 , A61K31/55
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译： 本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。 本发明还提供了使用本发明的药物组合物的治疗和预防方法。
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公开(公告)号：US20080103129A1
公开(公告)日：2008-05-01
申请号：US11858972
申请日：2007-09-21
申请人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence Wilson , Prabha Karnachi
发明人： Yue-Mei Zhang , Bangping Xiang , Shyh-Ming Yang , Kenneth Rhodes , Robert Scannevin , Paul Jackson , Davraj Chakravarty , Xiaodong Fan , Lawrence Wilson , Prabha Karnachi
IPC分类号： A61K31/55 , A61P35/00 , A61P25/00 , C07D403/02 , C07D223/02
CPC分类号： C07D413/06 , C07D211/94 , C07D213/69 , C07D213/89 , C07D223/12 , C07D225/02 , C07D243/08 , C07D401/12 , C07D403/12 , C07D409/12
摘要： This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要翻译： 本发明提供下式的新型杂环衍生基质金属蛋白酶抑制剂：包含其的药物组合物，可用于治疗通过拮抗基质金属蛋白酶而改善的病症。 本发明还提供了使用本发明的药物组合物的治疗和预防方法。
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