摘要:
The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
摘要:
The present invention is directed to a process for making Substituted Quinazoline Compounds of formula (I): which are useful for the treatment and prophylaxis of HCMV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
摘要:
The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要:
The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
摘要:
A second single-ended receiver having a first stage for receiving an input signal and outputting a pair of corresponding output signals, and a second stage for receiving the pair of output signals and outputting a corresponding single output signal. First and second pull-down transistors are coupled to first and second inputs to the first stage. A bias circuit electrically biases the first stage, second stage, and first and second pull-down transistors, and a power supply provides power to those components.
摘要:
The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applica
摘要:
The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要:
A hybrid binary/thermometer code is employed to adjust the output impedance of a variable impedance output driver circuit having an impedance network comprising a plurality of impedance legs each programmably electrically connectable according to the hybrid binary/thermometer code in parallel between a voltage source and the signal pad. The plurality of impedance legs are partitioned into one or more set pairs of binary stepped impedance legs and corresponding thermometer stepped impedance legs. A binary set of calibration signals in the hybrid binary/thermometer code steps a given set of binary stepped impedance legs according to a binary code and a thermometer set of calibration signals in the hybrid binary/thermometer code steps the corresponding set of thermometer stepped impedance legs according to a thermometer code once per full count iteration of the binary set of calibration signals.
摘要:
The present invention provides an asymmetric hydrogenation process for the preparation of chiral cycloalkanoindole DP receptor antagonists in high enantiomeric excess.
摘要:
A CMOS buffer with hysteresis is implemented. In one embodiment, an upper-trip circuit (102) and a lower-trip circuit (104) are implemented with CMOS inverters. The upper-trip circuit (102) and the lower-trip circuit (104) provides output to a pull-up device (110) and a pull-down device (111), respectively. The pull-up device (110) and the pull-down device (111) both generate an output signal onto a net (112). A bus holder (114) is coupled to the net (112) and maintains the output signal. In addition, an output circuit (116) is coupled to the net (112) and processes the output signal. In one embodiment, the output circuit is implemented with a CMOS buffer and functions as a buffer with hysteresis. In another embodiment, the output circuit is implemented with an inverter and functions as an inverting buffer with hysteresis. In a third embodiment, the output circuit is implemented with a connection (i.e., signal conveyance) and functions as a non-inverting buffer with hysteresis.