公开(公告)号：US20230257816A1

公开(公告)日：2023-08-17

申请号：US18015834

申请日：2021-07-12

申请人： Aoy Tomita MITCHELL ,  Michael MITCHELL ,  The Medical College of Wisconsin, Inc.

发明人： Aoy Tomita Mitchell ,  Michael Mitchell

IPC分类号： C12Q1/6883 ,  C12Q1/6851

CPC分类号： C12Q1/6883 ,  C12Q1/6851 ,  C12Q2600/158 ,  C12Q2600/118

摘要： This invention relates to methods and compositions for assessing or monitoring an amount of donor-specific fraction cell-free DNA from a transplant subject and comparing to specific threshold values for making treatment management decisions.

公开(公告)号：US20190150490A1

公开(公告)日：2019-05-23

申请号：US15818419

申请日：2017-11-20

申请人： Michael Mitchell

发明人： Michael Mitchell

IPC分类号： A23L19/00 ,  A23L5/43 ,  A23J1/00 ,  A23P30/00

摘要： Embodiments described herein provide a shelf-stable plant-based foodstuff composition having organic chickpea flour, salt, organic beet flour and flavoring agents. Each ingredient of the composition, when mixed with a leavening agent act as a meat substitute, such as a substitute for ground beef which may be used in a variety of recipes.

公开(公告)号：US09472232B2

公开(公告)日：2016-10-18

申请号：US14461898

申请日：2014-08-18

申请人： Jon Ashley ,  Michael Mitchell

发明人： Jon Ashley ,  Michael Mitchell

IPC分类号： B41F33/00 ,  G11B7/24094 ,  G11B7/007 ,  G11B23/40 ,  B41M3/00 ,  G11B7/24041

CPC分类号： G11B7/24094 ,  B41M3/008 ,  G11B7/00736 ,  G11B7/24041 ,  G11B23/40

摘要： Disclosed is an optical disc with a first area to store data for playback and that is reflective or opaque to visible light, and a second area that is transparent to visible light and includes first and second concentric rings. In one embodiment, a method of printing information on the optical disc includes: printing an inverse first text pattern in the first ring during a first printing on a first side, where the first text pattern is formed in reverse as viewed from the first side; printing a second text pattern in the second ring during a second printing on the first side, where the second text pattern is correctly visible from the first side; and printing, during the second printing, a first solid pattern to overlay at least a portion of the first text pattern, where the first text pattern is correctly visible as viewed from a second side.

摘要翻译： 公开了一种具有第一区域的光盘，用于存储用于重放的数据并且对可见光具有反射性或不透明性，以及对可见光透明并包括第一和第二同心环的第二区域。 在一个实施例中，在光盘上打印信息的方法包括：在第一侧的第一次打印期间，在第一环中打印反向第一文本图案，其中从第一侧观察第一文本图案是相反形成的; 在第一侧的第二打印期间在第二环中打印第二文本图案，其中第二文本图案从第一侧正确地可见; 以及在所述第二打印期间，打印第一固体图案以覆盖所述第一文本图案的至少一部分，其中所述第一文本图案从第二侧观察时是正确可见的。

公开(公告)号：US08850981B2

公开(公告)日：2014-10-07

申请号：US13033168

申请日：2011-02-23

申请人： Jon Ashley ,  Michael Mitchell

发明人： Jon Ashley ,  Michael Mitchell

IPC分类号： B41F33/00 ,  B41M3/00 ,  G11B7/007 ,  G11B23/40 ,  G11B7/24094 ,  G11B7/24041

CPC分类号： G11B7/24094 ,  B41M3/008 ,  G11B7/00736 ,  G11B7/24041 ,  G11B23/40

摘要： Disclosed is an optical disc with a first area to store data for playback and that is reflective or opaque to visible light, and a second area that is transparent to visible light and includes first and second concentric rings. In one embodiment, a method of printing information on the optical disc includes: printing an inverse first text pattern in the first ring during a first printing on a first side, where the first text pattern is formed in reverse as viewed from the first side; printing a second text pattern in the second ring during a second printing on the first side, where the second text pattern is correctly visible from the first side; and printing, during the second printing, a first solid pattern to overlay at least a portion of the first text pattern, where the first text pattern is correctly visible as viewed from a second side.

摘要翻译： 公开了一种具有第一区域的光盘，用于存储用于重放的数据并且对可见光具有反射性或不透明性，以及对可见光透明并包括第一和第二同心环的第二区域。 在一个实施例中，在光盘上打印信息的方法包括：在第一侧的第一次打印期间，在第一环中打印反向第一文本图案，其中从第一侧观察第一文本图案是相反形成的; 在第一侧的第二打印期间在第二环中打印第二文本图案，其中第二文本图案从第一侧正确地可见; 以及在所述第二打印期间，打印第一固体图案以覆盖所述第一文本图案的至少一部分，其中所述第一文本图案从第二侧观察时是正确可见的。

公开(公告)号：US08663921B2

公开(公告)日：2014-03-04

申请号：US12850588

申请日：2010-08-04

申请人： Aoy Tomita Mitchell ,  Michael Mitchell

发明人： Aoy Tomita Mitchell ,  Michael Mitchell

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  Y10T436/143333

摘要： The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome.

摘要翻译： 本发明提供串联单核苷酸多态性及其使用方法，例如诊断唐氏综合征。

公开(公告)号：US20130143219A1

公开(公告)日：2013-06-06

申请号：US13575874

申请日：2011-01-28

申请人： Aoy Tomita Mitchell ,  Michael Mitchell ,  Mats Hidestrand

发明人： Aoy Tomita Mitchell ,  Michael Mitchell ,  Mats Hidestrand

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6858 ,  C07H21/04 ,  C12Q1/6848 ,  C12Q1/6853 ,  C12Q2525/161 ,  C12Q2527/107

摘要： The present invention is directed to methods and compositions for amplifying nucleic acids. Included in the present invention are methods and compositions that amplify nucleic acids with high yield with the formation of unstable target extension products, preferably with minimal or no introduction of allelic bias. Also included in the present invention are high yield, instability primers for use in amplification methods, as multiplexed amplification methods.

摘要翻译： 本发明涉及用于扩增核酸的方法和组合物。 包括在本发明中的方法和组合物，其以高产率扩增核酸，形成不稳定的靶延伸产物，优选最小或不引入等位基因偏倚。 本发明还包括用作扩增方法的高产量，不稳定性引物，作为多重扩增方法。

公开(公告)号：US20120302305A1

公开(公告)日：2012-11-29

申请号：US13568680

申请日：2012-08-07

申请人： John Vallejo ,  Michael Mitchell ,  Loren T. Nelson

发明人： John Vallejo ,  Michael Mitchell ,  Loren T. Nelson

IPC分类号： A63F13/12 ,  A63F13/00

CPC分类号： G07F17/3258 ,  G07F17/32

摘要： A method and gaming machine are disclosed for operating a game with a primary and embedded game. An embedded game is disclosed as a bonus game with one embodiment animating miniature reels inside the primary game symbol. Each embedded slot game may have its own progressive, or may be tied into the progress associated with the primary game. Each embedded slot game will have its own paytable, and may be a miniature version of a well-recognized full-sized slot game. Also disclosed are a wagering game, a gaming machine and a networked gaming system and associated methods including a multiple-progressive wheel game. A player may win all of a set of wheel-based progressive award during play of a single game.

摘要翻译： 公开了一种用于操作具有主要和嵌入式游戏的游戏的方法和游戏机。 公开了一种嵌入式游戏作为奖励游戏，其中一个实施例是在主要游戏符号之内对微型卷轴进行动画化。 每个嵌入式老虎机游戏可能有自己的进步，或者可能被绑定到与主要游戏相关的进度。 每个嵌入式老虎机游戏都将拥有自己的付款方式，并且可能是一个被认可的全尺寸老虎机游戏的微型版本。 还公开了一种投注游戏，游戏机和网络游戏系统以及包括多进行轮游戏的相关方法。 玩家可以在单人游戏中赢得所有的一组轮子进步奖。

公开(公告)号：US20100184044A1

公开(公告)日：2010-07-22

申请号：US12581083

申请日：2009-10-16

申请人： Aoy Tomita Mitchell ,  Michael Mitchell

发明人： Aoy Tomita Mitchell ,  Michael Mitchell

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention is directed to compositions and methods for detecting genetic abnormalities. The present invention encompasses methods and compositions for comparing alleles in a sample containing both maternal and fetal nucleic acids in order to identify genetic abnormalities.

公开(公告)号：US20090176554A1

公开(公告)日：2009-07-09

申请号：US12401822

申请日：2009-03-11

申请人： John Vallejo ,  Michael Mitchell ,  Loren T. Nelson

发明人： John Vallejo ,  Michael Mitchell ,  Loren T. Nelson

IPC分类号： A63F9/24 ,  A63F13/00

CPC分类号： G07F17/3258 ,  G07F17/32

摘要： A method and gaming machine are disclosed for operating a game with a primary and embedded game. An embedded game is disclosed as a bonus game with one embodiment animating miniature reels inside the primary game symbol. Each embedded slot game may have its own progressive, or may be tied into the progress associated with the primary game. Each embedded slot game will have its own paytable, and may be a miniature version of a well-recognized full-sized slot game. Also disclosed are a wagering game, a gaming machine and a networked gaming system and associated methods including a multiple-progressive wheel game. A player may win all of a set of wheel-based progressive award during play of a single game.

摘要翻译： 公开了一种用于操作具有主要和嵌入式游戏的游戏的方法和游戏机。 公开了一种嵌入式游戏作为奖励游戏，其中一个实施例是在主要游戏符号之内对微型卷轴进行动画化。 每个嵌入式老虎机游戏可能有自己的进步，或者可能被绑定到与主要游戏相关的进度。 每个嵌入式老虎机游戏都将拥有自己的付款方式，并且可能是一个被认可的全尺寸老虎机游戏的微型版本。 还公开了一种投注游戏，游戏机和网络游戏系统以及包括多进行轮游戏的相关方法。 玩家可以在单人游戏中赢得所有的一组轮子进步奖。

公开(公告)号：US20080105611A1

公开(公告)日：2008-05-08

申请号：US11942334

申请日：2007-11-19

申请人： Dimitris Collias ,  Stephen Goldman ,  Michael Mitchell

发明人： Dimitris Collias ,  Stephen Goldman ,  Michael Mitchell

IPC分类号： B01D39/16

CPC分类号： B01D39/2062 ,  B01D2239/0485 ,  B01D2239/086 ,  B01D2239/1241 ,  B01D2239/125 ,  B01D2239/1258 ,  C02F1/283 ,  C02F1/288 ,  C02F2209/03 ,  C02F2209/40 ,  C02F2303/04

摘要： A filter block may comprise activated carbon filter particles without metallic biocides. The activated carbon filter particles may have a median particle size of less than or equal to about 90 microns and having a particle span of less than or equal to about 1.7. The filter block may have a permeability of greater than about 3.0×10−9 cm2 and a Filter Viruses Log Removal of greater than about 2 logs. A portion of the activated carbon filter particles may be coated with a cationic polymer. Another filter block may comprise mesoporous activated carbon filter particles without metallic biocides, wherein the mesoporous activated carbon filter particles may have a median particle size of less than or equal to about 104 μm and a particle span of less than or equal to about 2.05, and wherein at least a portion of the filter particles may be coated with a cationic polymer. The filter block may have a permeability of greater than about 2.0×10−9 cm2 and a Filter Viruses Log Removal of greater than about 2 logs.

摘要翻译： 过滤块可以包括没有金属杀生物剂的活性炭过滤器颗粒。 活性炭过滤器颗粒可以具有小于或等于约90微米的中值粒度并且具有小于或等于约1.7的颗粒跨度。 过滤器块可以具有大于约3.0×10 -9 cm 2的渗透率和大于约2log的过滤器病毒对数去除。 活性炭过滤器颗粒的一部分可以用阳离子聚合物涂覆。 另一个过滤器块可以包括没有金属杀生物剂的中孔活性炭过滤器颗粒，其中介孔活性炭过滤器颗粒可以具有小于或等于约104μm的中值粒径和小于或等于约2.05的颗粒跨度，以及 其中至少一部分过滤颗粒可以用阳离子聚合物涂覆。 过滤块可以具有大于约2.0×10 -9 cm 2的渗透率和大于约2个对数的过滤器病毒对数去除。