公开(公告)号：US20050048531A1

公开(公告)日：2005-03-03

申请号：US10809189

申请日：2004-03-25

申请人： Michael Mittman ,  David Mack ,  David Lockhart

发明人： Michael Mittman ,  David Mack ,  David Lockhart

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12M1/34

CPC分类号： C12Q1/6883 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/6837 ,  C12Q2600/156

摘要： The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of murine genes. The invention provides the sequences in such a way as to make them available for a variety of analyses. As such, the invention related to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, and medical diagnostics.

摘要翻译： 本发明提供在一个实施方案中与多种鼠基因互补的核酸序列。 本发明提供了这样的顺序，使得它们可用于各种分析。 因此，本发明涉及由分子相互作用的性质（包括化学，生物学，医学和医学诊断）影响的不同领域。

公开(公告)号：US09197079B2

公开(公告)日：2015-11-24

申请号：US13458996

申请日：2012-04-27

申请人： Sean Yip ,  David Mack

发明人： Sean Yip ,  David Mack

IPC分类号： H02J7/00

CPC分类号： H02J7/0014 ,  A61H31/004 ,  H02J7/0006 ,  H02J7/0021 ,  H02J7/0026 ,  H02J7/0045 ,  H02J7/0047 ,  H02J2007/0096

摘要： An intelligent rechargeable battery pack having a battery management system for monitoring and controlling the charging and discharging of the battery pack is described. The battery management system includes a memory for storing data related to the operation of the battery, and the battery management system is also configured to communicate the data related to the operation of the battery to other processors for analysis.

摘要翻译： 描述了具有用于监测和控制电池组的充电和放电的电池管理系统的智能可充电电池组。 电池管理系统包括用于存储与电池的操作相关的数据的存储器，并且电池管理系统还被配置为将与电池的操作相关的数据传送到其他处理器用于分析。

公开(公告)号：US08547055B2

公开(公告)日：2013-10-01

申请号：US11685913

申请日：2007-03-14

申请人： David Mack

发明人： David Mack

IPC分类号： H02J7/14 ,  H02J7/00

CPC分类号： B60W20/15 ,  B60K1/02 ,  B60K6/365 ,  B60K6/445 ,  B60K6/547 ,  B60W10/08 ,  B60W10/26 ,  B60W10/28 ,  B60W10/30 ,  B60W20/00 ,  B60W2510/244 ,  B60W2710/28 ,  H02J1/14 ,  H02J7/1423 ,  H02J7/1438 ,  H02J7/1461 ,  Y02T10/6239 ,  Y02T10/7005 ,  Y02T10/92

摘要： A system and method for controlling the electrical power consumption of an accessory device. A power transmission unit is adapted to generate electrical power. The system comprises a first controller, a current sensor and a second controller. The first controller is adapted to control the operation of the accessory device. The current sensor is configured to measure an amount of current being charged and discharged to and from the battery and generate a signal that corresponds to the measured amount of current charged and discharged to and from the battery. The second controller is configured to receive the signal from the current sensor and generate flag signal in response to detecting that current is being charged to the battery. The first controller is further adapted to control the accessory device to consume increased power from the electrical power generated by the power transmission unit in response to the flag signal.

摘要翻译： 一种用于控制附件装置的电力消耗的系统和方法。 电力传输单元适于产生电力。 该系统包括第一控制器，电流传感器和第二控制器。 第一控制器适于控制附件设备的操作。 电流传感器被配置为测量正在从电池充电和放电的电流量，并产生对应于从电池充放电的测量量的信号。 第二控制器被配置为从电流传感器接收信号并且响应于检测到电流被充电到电池而产生标志信号。 第一控制器还适于控制附件设备响应于标志信号从功率传输单元产生的电力消耗增加的功率。

公开(公告)号：US20070067111A1

公开(公告)日：2007-03-22

申请号：US11489292

申请日：2006-07-18

申请人： David Mack ,  Kurt Gish ,  David Balaban ,  Elina Khurgin ,  Josie Dai ,  Jim Snyder

发明人： David Mack ,  Kurt Gish ,  David Balaban ,  Elina Khurgin ,  Josie Dai ,  Jim Snyder

IPC分类号： G06F19/00

CPC分类号： G06T11/206 ,  C12N15/1089 ,  C12Q1/68 ,  G16B25/00 ,  G16B45/00

摘要： Innovative systems and methods for visualizing information collected from analyzing samples are provided. The samples may include nucleic acids, proteins, or other polymers. Gene expression level as determined from analysis of a nucleic acid sample is one possible analysis result that may be visualized. In one embodiment, a computer system may display the expression levels of multiple genes simultaneously in a way that facilitates user identification of genes whose expression is significant to a characteristic such as disease or resistance to disease. Additionally, the computer system may facilitate display of further information about relevant genes once they are identified.

摘要翻译： 提供了从分析样品收集的信息可视化的创新系统和方法。 样品可以包括核酸，蛋白质或其它聚合物。 从核酸样品的分析确定的基因表达水平是可以被可视化的一个可能的分析结果。 在一个实施方案中，计算机系统可以以促进用户识别其表达对特征如疾病或抗性的重要性的基因的方式同时显示多个基因的表达水平。 此外，一旦识别出相关基因，计算机系统可以便于显示关于相关基因的进一步信息。

公开(公告)号：US20070059712A1

公开(公告)日：2007-03-15

申请号：US11212799

申请日：2005-08-24

申请人： Kurt Gish ,  David Mack ,  Keith Wilson ,  Peter Hevezi

发明人： Kurt Gish ,  David Mack ,  Keith Wilson ,  Peter Hevezi

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/34

CPC分类号： C12Q1/6886 ,  C07K16/3069 ,  C12Q2600/136 ,  G01N2800/52

摘要： Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein are methods that can be used to identify modulators of prostate cancer.

公开(公告)号：US20050169841A1

公开(公告)日：2005-08-04

申请号：US11088004

申请日：2005-03-22

申请人： Richard Glynne ,  Chris Goodnow ,  David Mack

发明人： Richard Glynne ,  Chris Goodnow ,  David Mack

IPC分类号： C07B61/00 ,  G01N33/50 ,  A61K49/00 ,  C12Q1/68

CPC分类号： G01N33/5052 ,  C40B40/00 ,  G01N2500/10

摘要： The invention provides for the identification of all genes, whether known or novel, which are differentially expressed within and among B cells, making possible the characterization of their temporal regulation and function in the B cell response and/or in B cell mediated disorders. Expression profiles, nucleic acids and proteins are provided for differing states of B cells, including resting, naïve, activated, tolerant and immunosuppressed B cells. The present invention makes possible the identification and characterization of targets useful in prognosis, diagnosis, monitoring, rational drug design, and/or therapeutic intervention of immune system disorders.

摘要翻译： 本发明提供了鉴定在B细胞内和B细胞内差异表达的所有基因，无论是已知的还是新的，使得其可能表征其在B细胞应答和/或B细胞介导的病症中的时间调节和功能。 提供表达谱，核酸和蛋白质用于B细胞的不同状态，包括休息，初始，活化，耐受和免疫抑制的B细胞。 本发明使得可以鉴定和表征可用于预后，诊断，监测，合理药物设计和/或免疫系统疾病的治疗干预的靶标。

公开(公告)号：US20050032065A1

公开(公告)日：2005-02-10

申请号：US10603505

申请日：2003-06-24

申请人： Daniel Afar ,  Susan Henshall ,  Jordan Hiller ,  David Mack ,  Robert Sutherland

发明人： Daniel Afar ,  Susan Henshall ,  Jordan Hiller ,  David Mack ,  Robert Sutherland

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  Y02A90/26

摘要： The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.

摘要翻译： 本发明将经典生存分析应用于前列腺癌患者的前列腺癌基因组全基因表达谱和术前前列腺特异性抗原水平，以鉴定提供相对于前列腺特异性抗原浓度的额外预测值的疾病复发的预后标志物。 本发明提供一种确定前列腺癌的预后并预测患者的前列腺癌预后的方法。 该方法包括首先建立至少一种前列腺癌预后基因的阈值的步骤。 然后，确定来自前列腺癌患者的前列腺组织的预后基因的量。 将该患者中存在的预后基因的量与预后基因的既定阈值进行比较，从而确定患者的预后结果。

公开(公告)号：US06294343B1

公开(公告)日：2001-09-25

申请号：US09436983

申请日：1999-11-09

申请人： David Mack ,  Kurt C. Gish ,  Keith E. Wilson

发明人： David Mack ,  Kurt C. Gish ,  Keith E. Wilson

IPC分类号： G01N3353

CPC分类号： G01N33/5011 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/4748 ,  G01N33/57419

摘要： Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate colorectal cancer. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in colorectal and other cancers are described.

摘要翻译： 本文描述了可用于结肠直肠癌的诊断和预后的方法。 本文还描述了可用于筛选候选生物活性剂以调节结肠直肠癌的能力的方法。 此外，描述了用于治疗性干预结肠直肠癌和其他癌症的方法和分子靶标（基因及其产物）。

公开(公告)号：US20120274280A1

公开(公告)日：2012-11-01

申请号：US13458996

申请日：2012-04-27

申请人： Sean Yip ,  David Mack

发明人： Sean Yip ,  David Mack

IPC分类号： H02J7/00

CPC分类号： H02J7/0014 ,  A61H31/004 ,  H02J7/0006 ,  H02J7/0021 ,  H02J7/0026 ,  H02J7/0045 ,  H02J7/0047 ,  H02J2007/0096

摘要： An intelligent rechargeable battery pack having a battery management system for monitoring and controlling the charging and discharging of the battery pack is described. The battery management system includes a memory for storing data related to the operation of the battery, and the battery management system is also configured to communicate the data related to the operation of the battery to other processors for analysis.

摘要翻译： 描述了具有用于监测和控制电池组的充电和放电的电池管理系统的智能可充电电池组。 电池管理系统包括用于存储与电池的操作相关的数据的存储器，并且电池管理系统还被配置为将与电池的操作相关的数据传送到其他处理器用于分析。

公开(公告)号：US20110117013A1

公开(公告)日：2011-05-19

申请号：US12796244

申请日：2010-06-08

申请人： David Mack ,  Kurt C. Gish

发明人： David Mack ,  Kurt C. Gish

IPC分类号： A61K51/10 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K49/0002 ,  A61K49/0008 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/3015 ,  C07K16/3069 ,  C07K2317/73 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/57415 ,  G01N33/57434 ,  G01N33/5748

摘要： Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

摘要翻译： 本文描述了可用于诊断和治疗癌症的方法和组合物。