公开(公告)号：US09457014B2

公开(公告)日：2016-10-04

申请号：US14391785

申请日：2012-07-30

申请人： Daniel Lawton ,  Michael Neary ,  James A. Nieman

发明人： Daniel Lawton ,  Michael Neary ,  James A. Nieman

IPC分类号： A61K38/12 ,  A61K31/426 ,  C07D277/14 ,  A61K31/198 ,  A61K45/06 ,  C07D241/08 ,  C07D267/10 ,  C07K5/062

CPC分类号： A61K31/426 ,  A61K31/198 ,  A61K45/06 ,  C07D241/08 ,  C07D267/10 ,  C07D277/14 ,  C07K5/0606

摘要： Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.

摘要翻译： 新型半胱氨酸前药及其用于治疗疾病和/或病症，包括但不限于中枢神经系统（CNS）的疾病和/或病症，包括但不限于精神分裂症，药物渴求，药物成瘾，双相情感障碍 ，焦虑症，抑郁症，帕金森病，阿尔茨海默病，认知功能障碍，多发性硬化，肌萎缩性侧索硬化（ALS），缺血性卒中，艾滋病毒痴呆和亨廷顿疾病。

公开(公告)号：US20060087351A1

公开(公告)日：2006-04-27

申请号：US10974852

申请日：2004-10-27

申请人： Lee Molho ,  Michael Neary

发明人： Lee Molho ,  Michael Neary

IPC分类号： H03L7/06

CPC分类号： H03L7/091

摘要： A signal synchronizer according to embodiments herein uses a delay register that receives a feedback signal. The delay register has many delay circuits, each of which are adapted to delay the feedback signal at different time intervals. A storage register made up of many binary storage devices receives a reference signal. Each storage device is adapted to store a feedback signal state of a corresponding delay circuit. As the feedback signal is delayed the additional time intervals by the successive delay circuits, it will change states (either from high to low, or low to high) and the different storage devices simultaneously store the feedback signal states of each of the delay circuits, as controlled by the reference signal. The change in feedback signal state between adjacent storage devices records a synchronization separation between the feedback signal and the reference signal. A control device synchronizes the feedback signal based on the synchronization separation as recorded by the storage register.

摘要翻译： 根据本文实施例的信号同步器使用接收反馈信号的延迟寄存器。 延迟寄存器具有许多延迟电路，每个延迟电路适于以不同的时间间隔延迟反馈信号。 由许多二进制存储装置构成的存储寄存器接收参考信号。 每个存储设备适于存储对应的延迟电路的反馈信号状态。 由于反馈信号由连续延迟电路延迟附加时间间隔，它将改变状态（从高到低或从低到高），并且不同的存储设备同时存储每个延迟电路的反馈信号状态， 由参考信号控制。 相邻存储设备之间的反馈信号状态的变化记录反馈信号和参考信号之间的同步间隔。 控制装置基于由存储寄存器记录的同步分离来同步反馈信号。

公开(公告)号：US20060085679A1

公开(公告)日：2006-04-20

申请号：US11213630

申请日：2005-08-26

申请人： Michael Neary ,  Ashwani Wason ,  Shvetima Gulati ,  Fabrice Ferval

发明人： Michael Neary ,  Ashwani Wason ,  Shvetima Gulati ,  Fabrice Ferval

IPC分类号： G06F11/00

CPC分类号： G06F11/30 ,  G06F11/1438 ,  G06F11/1482 ,  G06F11/2028 ,  G06F11/203

摘要： Incremental single and multiprocess checkpointing and restoration is described, which is transparent in that the application program need not be modified, re-compiled, or re-linked to gain the benefits of the invention. The processes subject to checkpointing can be either single or multi-threaded. The method includes incremental page-boundary checkpointing, as well as storage checkpointing of data files associated with applications to ensure correct restoration without the need to restore files for other application programs. Incremental and full checkpoints are asynchronously merged to ensure proper operation while reducing checkpointing delay. By way of example a user-level programming library is described for loading into the address space of the application in conjunction with a loadable kernel module (LKM) or device driver used to capture and restore process state on behalf of the application. These techniques are particularly well suited for use with high-availability (HA) protection programming.

摘要翻译： 描述了增量单和多进程检查点和恢复，这是透明的，因为应用程序不需要被修改，重新编译或重新链接以获得本发明的优点。 进行检查点处理的过程可以是单线程或多线程。 该方法包括增量页面边界检查点，以及与应用程序相关联的数据文件的存储检查点，以确保正确的恢复，而无需为其他应用程序恢复文件。 递增和完整检查点被异步合并，以确保正确的操作，同时减少检查点延迟。 作为示例，用户级编程库被描述为与用于代表应用程序捕获和恢复进程状态的可加载内核模块（LKM）或设备驱动程序一起加载到应用程序的地址空间中。 这些技术特别适用于高可用性（HA）保护编程。

公开(公告)号：US20160287563A1

公开(公告)日：2016-10-06

申请号：US15174410

申请日：2016-06-06

申请人： Daniel Lawton ,  Michael Neary ,  James A. Nieman

发明人： Daniel Lawton ,  Michael Neary ,  James A. Nieman

IPC分类号： A61K31/426

CPC分类号： A61K31/426 ,  A61K31/198 ,  A61K45/06 ,  C07D241/08 ,  C07D267/10 ,  C07D277/14 ,  C07K5/0606

摘要： Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.

摘要翻译： 新型半胱氨酸前药及其用于治疗疾病和/或病症，包括但不限于中枢神经系统（CNS）的疾病和/或病症，包括但不限于精神分裂症，药物渴求，药物成瘾，双相情感障碍 ，焦虑症，抑郁症，帕金森病，阿尔茨海默病，认知功能障碍，多发性硬化，肌萎缩性侧索硬化（ALS），缺血性卒中，艾滋病毒痴呆和亨廷顿疾病。

公开(公告)号：US20160081987A1

公开(公告)日：2016-03-24

申请号：US14391785

申请日：2012-07-30

申请人： Daniel Lawton ,  Michael Neary ,  James A. Nieman

发明人： Daniel Lawton ,  Michael Neary ,  James A. Nieman

IPC分类号： A61K31/426 ,  C07D277/14 ,  A61K45/06 ,  C07D241/08 ,  A61K31/198 ,  C07D267/10 ,  C07K5/062

CPC分类号： A61K31/426 ,  A61K31/198 ,  A61K45/06 ,  C07D241/08 ,  C07D267/10 ,  C07D277/14 ,  C07K5/0606

摘要： Novel cysteine prodrugs and their use in the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug craving, drug addiction, bipolar disorder, anxiety, depression, Parkinson's disease, Alzheimer's disease, cognitive dysfunction, multiple sclerosis, Amyotrophic lateral sclerosis (ALS), ischemic stroke, HIV dementia, and Huntington's disease.

公开(公告)号：US20070046768A1

公开(公告)日：2007-03-01

申请号：US11211703

申请日：2005-08-26

申请人： Michael Neary ,  Daniel Wong

发明人： Michael Neary ,  Daniel Wong

IPC分类号： B41J2/47 ,  B41J2/435

CPC分类号： G06K15/1219

摘要： This invention relates to an efficient way to calibrate and control a raster output scanner (ROS). The scan non-linearity of a ROS may be measured and an appropriate calibration curve setting for the ROS may be determined. The setting and other scan line parameters may then be used as an address to a memory, such as a read-only memory (ROM). The memory may store a set of calibration curve data and the address is used to look up the data from one of these curves. The ROS may then be controlled based on the calibration data retrieved from memory.

摘要翻译： 本发明涉及校准和控制光栅输出扫描器（ROS）的有效方法。 可以测量ROS的扫描非线性，并且可以确定ROS的适当的校准曲线设置。 然后可以将设置和其它扫描线参数用作存储器的地址，诸如只读存储器（ROM）。 存储器可以存储一组校准曲线数据，并且该地址用于从这些曲线之一查找数据。 然后可以基于从存储器检索的校准数据来控制ROS。

公开(公告)号：US20060228076A1

公开(公告)日：2006-10-12

申请号：US11093038

申请日：2005-03-30

申请人： Michael Neary

发明人： Michael Neary

IPC分类号： G02B6/36

CPC分类号： G02B6/43 ,  G02B6/4249

摘要： A communication coupling technique is disclosed that uses optical signals separators that may be formed using optical wave guides, hollow tubes, or any material that separates signals emitted from one source from signals emitted from other sources.

摘要翻译： 公开了一种通信耦合技术，其使用可以使用光波导，中空管或将从一个源发射的信号与从其它源发射的信号分离的任何材料形成的光信号分离器。