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1.发明申请Methods for producing substituted acrylic acid esters and use of the latter for producing substituted $G (G)-amino acids 有权制备取代的丙烯酸酯的方法，其用于制备取代的G（G） - 氨基酸公开(公告)号：US20050043565A1
公开(公告)日：2005-02-24
申请号：US10894389
申请日：2004-07-19
申请人： Michael Przewosny , Claudia Putz
发明人： Michael Przewosny , Claudia Putz
IPC分类号： C07C61/22 , C07C61/26 , C07C67/343 , C07C69/533 , C07C69/54 , C07C69/608 , C07C227/22 , C07C229/08 , C07C229/28
CPC分类号： C07C227/22 , C07C67/343 , C07C2601/14 , C07C69/608 , C07C69/533 , C07C229/08 , C07C229/28
摘要： The invention relates to methods for producing substituted acrylic acid esters and to the use of the latter for producing substituted γ-amino acids, such as gabapentin and pregabalin. The substituted acrylic acid esters are produced by Wadsworth-Emmons olefination with trialkyl phosphonoacetate in the presence of alkali carbonate as the base, in an aqueous solvent.
摘要翻译： 本发明涉及生产取代的丙烯酸酯的方法，以及用于制备取代的γ-氨基酸如加巴喷丁和普瑞巴林的方法。 在碱性碳酸酯作为碱的存在下，在水性溶剂中，通过Wadsworth-Emmons烯化与三烷基膦酰基乙酸酯制备取代的丙烯酸酯。
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公开(公告)号：US08791268B2
公开(公告)日：2014-07-29
申请号：US13077452
申请日：2011-03-31
申请人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jeewoo Lee
发明人： Robert Frank , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jeewoo Lee
IPC分类号： A61K31/44 , C07D213/62
CPC分类号： C07D213/74 , C07D213/64 , C07D213/70
摘要： Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.
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![Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs](/abs-image/US/2012/04/10/US08153795B2/abs.jpg.150x150.jpg)
3.发明授权Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs 有权取代的1-氧杂-3,8-二氮杂螺[4.5]癸烷-2-酮化合物及其制备药物的用途公开(公告)号：US08153795B2
公开(公告)日：2012-04-10
申请号：US11994001
申请日：2006-06-27
IPC分类号： C07D491/10 , A61K31/44
CPC分类号： C07D498/10
摘要： The present invention relates to substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.
摘要翻译： 本发明涉及取代的1-氧杂-3,8-二氮杂螺[4.5]癸烷-2-酮化合物，其制备方法，含有这些化合物的药物以及这些化合物用于生产药物的用途。
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4.发明申请Pharmaceutical formulations containing substituted 2 heteroarylaminoacetic acid compounds 失效含有取代的2个杂芳基氨基乙酸化合物的药物制剂公开(公告)号：US20060025473A1
公开(公告)日：2006-02-02
申请号：US11202074
申请日：2005-08-12
IPC分类号： A61K31/381 , A61K31/343
CPC分类号： A61K31/381 , A61K31/343
摘要： Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds corresponding to formula I and their use in the production of drugs and in related methods of treatment or inhibition of certain conditions or diseases.
摘要翻译： 含有对应于式I的取代的2-芳基 - 氨基乙酸化合物的药物制剂及其在制备药物中的用途以及治疗或抑制某些病症或疾病的相关方法。
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5.发明申请Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds 失效取代的C-呋喃-2-基 - 甲胺和C-噻吩-2-基 - 甲胺化合物公开(公告)号：US20050148550A1
公开(公告)日：2005-07-07
申请号：US11072962
申请日：2005-03-07
IPC分类号： A61K31/341 , A61P1/08 , A61P1/12 , A61P9/00 , A61P9/06 , A61P13/02 , A61P17/04 , A61P23/02 , A61P25/04 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P25/32 , A61P29/00 , A61P29/02 , C07B61/00 , C07D307/68 , A61K31/655 , A61K31/381 , A61K31/416 , C07D49/02
CPC分类号： C07D307/68
摘要： Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in treatment methods and in the preparation of analgesics, in the preparation of a local anaesthetic, an antiarrhythmic, an antiemetic, a nootropic agent and/or a medicament for the treatment and/or prophylaxis of cardiovascular diseases, urinary incontinence, diarrhea, pruritus and/or inflammations, and/or a medicament for the treatment of depression and/or alcohol and/or drug and/or medicament abuse, and/or a medicament for increasing vigilance.
摘要翻译： 取代的C-呋喃-2-基 - 甲胺和C-噻吩-2-基 - 甲胺化合物，其制备方法，含有它们的药物和药物组合物及其在治疗方法中的用途和在制备中的镇痛药 局部麻醉剂，抗心律失常药，止吐药，益智药和/或用于治疗和/或预防心血管疾病，尿失禁，腹泻，瘙痒和/或炎症的药物，和/或用于治疗 抑郁症和/或酒精和/或药物和/或药物滥用，和/或用于提高警惕性的药物。
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6.发明申请Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof For Treating Pain and Other Conditions 有权香草素受体配体，含有它们的药物组合物及其制备方法及其用途，用于治疗疼痛和其他病症公开(公告)号：US20110184020A1
公开(公告)日：2011-07-28
申请号：US13077452
申请日：2011-03-31
申请人： Robert FRANK , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jeewoo Lee
发明人： Robert FRANK , Gregor Bahrenberg , Thomas Christoph , Klaus Schiene , Jean De Vry , Derek Saunders , Michael Przewosny , Bernd Sundermann , Jeewoo Lee
IPC分类号： A61K31/4545 , A61K31/44 , C07D401/04 , C07D213/70 , C07D213/64 , A61P9/12 , A61P29/00 , A61P25/06 , A61P25/24 , A61P25/28 , A61P25/08 , A61P25/00 , A61P25/16 , A61P11/00 , A61P1/04 , A61P1/00 , A61P1/12 , A61P19/02 , A61P25/32 , A61P9/00 , A61P17/02 , A61P11/06 , A61P3/04
CPC分类号： C07D213/74 , C07D213/64 , C07D213/70
摘要： Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.
摘要翻译： 对应于式I的香草酸受体配体化合物：制备这种化合物的方法，含有它们的药物组合物，以及这些化合物用于治疗疼痛和各种其它香草素受体介导的病症的用途。
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7.发明授权公开(公告)号：US06943181B2
公开(公告)日：2005-09-13
申请号：US10751737
申请日：2004-01-05
IPC分类号： A61K31/365 , A61K31/4155 , A61K31/443 , A61K31/473 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/517 , A61P3/10 , A61P25/16 , A61P25/28 , A61P31/10 , A61P35/00 , A61K31/4525 , A61K31/4164 , A61K31/4709
CPC分类号： A61K31/443 , A61K31/365 , A61K31/4155 , A61K31/473 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/517
摘要： The invention relates to the use of substituted gamma-lactone compounds in the production of medicines for treating migraines, septic shock, neurodegenerative diseases, such as multiple sclerosis, Parkinsons, Alzheimers or Huntingtons disease, inflammations and related pain, cerebral ischaemia, diabetes, meningitis, arteriosclerosis, cancer, mycosis, or for healing wounds.
摘要翻译： 本发明涉及取代的γ-内酯化合物在制备用于治疗偏头痛，败血性休克，神经变性疾病如多发性硬化，帕金森，阿尔茨海默病或亨廷顿病，炎症和相关疼痛，脑缺血，糖尿病，脑膜炎 ，动脉硬化，癌症，真菌病或愈合伤口。
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公开(公告)号：US06878740B2
公开(公告)日：2005-04-12
申请号：US10717932
申请日：2003-11-21
IPC分类号： A61K31/341 , A61P1/08 , A61P1/12 , A61P9/00 , A61P9/06 , A61P13/02 , A61P17/04 , A61P23/02 , A61P25/04 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P25/32 , A61P29/00 , A61P29/02 , C07B61/00 , C07D307/68 , C07D307/52 , C07D409/12
CPC分类号： C07D307/68
摘要： Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in treatment methods and in the preparation of analgesics, in the preparation of a local anaesthetic, an antiarrhythmic, an antiemetic, a nootropic agent and/or a medicament for the treatment and/or prophylaxis of cardiovascular diseases, urinary incontinence, diarrhea, pruritus and/or inflammations, and/or a medicament for the treatment of depression and/or alcohol and/or drug and/or medicament abuse, and/or a medicament for increasing vigilance.
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9.发明授权Substituted amino-furan-2-yl-acetic acid and amino-thien-2-yl-acetic acid derivatives and their use in the treatment of migraine and pain 失效取代的氨基 - 呋喃-2-基 - 乙酸和氨基噻吩-2-基 - 乙酸衍生物及其在治疗偏头痛和疼痛中的应用公开(公告)号：US06797712B2
公开(公告)日：2004-09-28
申请号：US10448323
申请日：2003-05-30
IPC分类号： A61K3134
CPC分类号： C07D307/56 , C07D307/54 , C07D307/68 , C07D333/24 , C07D405/12 , C07D409/12
摘要： Compounds of formula I, or a pharmaceutically acceptable salt thereof, The compounds of the present invention are suitable for the treatment of pain and migraine. Also disclosed are method for preparing the compounds, and pharmaceutical composition comprising the compounds as well as methods for treating pain and migraine using the pharmaceutical compositions.
摘要翻译： 式I化合物或其药学上可接受的盐本发明化合物适用于治疗疼痛和偏头痛。 还公开了制备化合物的方法，以及包含该化合物的药物组合物以及使用该药物组合物治疗疼痛和偏头痛的方法。
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10.发明授权Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds 失效含有取代的2-芳基 - 氨基乙酸化合物和/或取代的2-杂芳基 - 氨基乙酸化合物的药物制剂公开(公告)号：US07432296B2
公开(公告)日：2008-10-07
申请号：US11202037
申请日：2005-08-12
CPC分类号： A61K31/343 , A61K31/198 , A61K31/381 , A61K31/385 , A61K31/39
摘要： Pharmaceutical formulations containing substituted 2-aryl-aminoacetic acid compounds and/or substituted 2-heteroaryl-aminoacetic acid compounds corresponding to formula I, as well as to their use in the production of drugs and in related methods of treating or inhibiting pain and neurodegenerative disease.
摘要翻译： 含有对应于式I的取代的2-芳基 - 氨基乙酸化合物和/或取代的2-杂芳基 - 氨基乙酸化合物的药物制剂以及它们在制备药物中的用途以及用于治疗或抑制疼痛和神经变性疾病的相关方法 。
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