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50 条记录 (耗时 0.035 秒)

    Angioplasty device
    1.
    发明授权
    Angioplasty device 失效
    血管成形术装置

    公开(公告)号：US5505699A

    公开(公告)日：1996-04-09

    申请号：US217306

    申请日：1994-03-24

    申请人： Michael R. Forman ,  Michael N. Helmus ,  Joseph E. Laptewicz, Jr.

    发明人： Michael R. Forman ,  Michael N. Helmus ,  Joseph E. Laptewicz, Jr.

    IPC分类号： A61M25/00 ,  A61F2/82 ,  A61M29/02 ,  A61M29/00

    CPC分类号： A61M25/104 ,  A61M2025/0186 ,  A61M2025/09141 ,  A61M2025/1015 ,  A61M2025/1093

    摘要： This invention relates to an angioplasty device that is formed from a hollow metallic tube, a balloon affixed adjacent the distal end of the tube and being in fluid communication with the lumen of the tube, a flexible distal segment connected to the distal end of the tube and a removable hub connected adjacent to the proximal end of the tube. The tube is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this angioplasty device.

    摘要翻译： 本发明涉及一种由中空金属管形成的血管成形术装置，邻近管的远端固定并与管的内腔流体连通的球囊，连接到管的远端的柔性远端段 以及与管的近端相邻连接的可移除的轮毂。 该管优选由诸如镍 - 钛合金的超弹性材料形成。 本发明还涉及使用该血管成形术装置的各种方法。

    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel
    7.
    发明授权
    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel 失效
    含有聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法，该水凝胶与至少一种其它不同的聚合物水凝胶

    公开(公告)号：US5576072A

    公开(公告)日：1996-11-19

    申请号：US382459

    申请日：1995-02-01

    申请人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    发明人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    IPC分类号： A61L29/04 ,  A61L29/08 ,  B05D7/00 ,  B05D7/02 ,  C08G18/10 ,  C08G18/48 ,  C08G18/75 ,  C09D175/04 ,  B05D3/00 ,  B29C71/02 ,  C04B41/00 ,  H05H1/00

    CPC分类号： B05D7/54 ,  A61L29/049 ,  A61L29/085 ,  B05D7/02 ,  C08G18/10 ,  C08G18/4833 ,  C08G18/4837 ,  C08G18/755 ,  C08G18/758 ,  C09D175/04 ,  C08G2210/00 ,  Y10T428/31551

    摘要： A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and at least one other polymer hydrogel of a polymer different from polyurethane-polyurea; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

    摘要翻译： 制备聚氨酯 - 聚脲聚合物水凝胶的混合水凝胶和不同于聚氨酯 - 聚脲的聚合物的至少一种其它聚合物水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这样的应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长期使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel
    9.
    发明授权
    Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel 失效
    含有聚（N-乙烯基吡咯烷酮）聚合物水凝胶的聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法

    公开(公告)号：US5662960A

    公开(公告)日：1997-09-02

    申请号：US384711

    申请日：1995-02-01

    申请人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    发明人： Fritz Hostettler ,  David Rhum ,  Michael R. Forman ,  Michael N. Helmus ,  Ni Ding

    IPC分类号： A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61L31/10 ,  B05D1/36 ,  B05D7/00 ,  B05D7/02 ,  B05D7/16 ,  B05D7/24 ,  C08G18/10 ,  C08J7/00 ,  C08J7/04 ,  B05D3/10 ,  B05D3/04 ,  C23C14/02

    CPC分类号： B05D7/52 ,  A61L29/085 ,  A61L31/10 ,  B05D7/02 ,  B05D7/16 ,  C08G18/10 ,  C08G2210/00 ,  C08G2270/00

    摘要： A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and a poly(N-vinylpyrrolidone) polymer hydrogel; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.

    摘要翻译： 一种制备聚氨酯 - 聚脲聚合物水凝胶和聚（N-乙烯基吡咯烷酮）聚合物水凝胶的混合水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这种应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长时间使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。

    Drug delivery guidewire
    10.
    发明授权
    Drug delivery guidewire 失效
    药物输送导丝

    公开(公告)号：US5569197A

    公开(公告)日：1996-10-29

    申请号：US360488

    申请日：1994-12-21

    申请人： Michael N. Helmus ,  Michael R. Forman

    发明人： Michael N. Helmus ,  Michael R. Forman

    IPC分类号： A61M25/01 ,  A61F2/06 ,  A61F2/84 ,  A61M25/00 ,  A61M25/09 ,  A61M29/02 ,  A61M29/00

    CPC分类号： A61M25/09 ,  A61F2/95 ,  A61M2025/091 ,  A61M2025/09175 ,  A61M25/007 ,  A61M25/104

    摘要： This invention relates to a drug delivery device having a hollow tube which is configured to serve as a guide wire for intraluminal procedures. The distal portion of the tube has at least one opening which has a diameter suitable for the infusion of a drug formulation therethrough. The tube is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this drug delivery device in thrombolytic and other intraluminal procedures.

    摘要翻译： 本发明涉及具有中空管的药物输送装置，该中空管构造成用作管腔内手术的导丝。 管的远端部分具有至少一个开口，其具有适合于通过其注入药物制剂的直径。 该管优选由诸如镍 - 钛合金的超弹性材料形成。 本发明还涉及在血栓溶解和其它腔内手术中使用该药物递送装置的各种方法。