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公开(公告)号：US20110183964A1
公开(公告)日：2011-07-28
申请号：US13082956
申请日：2011-04-08
申请人： Michael SHULTZ , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Jianmei FAN , Gang LIU , Dyuti MAJUMDAR , Jianke LI
发明人： Michael SHULTZ , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Jianmei FAN , Gang LIU , Dyuti MAJUMDAR , Jianke LI
IPC分类号： A61K31/55 , A61P35/00 , A61P35/02 , A61K31/404 , A61K31/4155 , A61K31/437 , A61K31/40 , A61K31/4025 , A61K31/497 , A61K31/422 , A61K31/41 , A61K31/496
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，Y，Z如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
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公开(公告)号：US20090247547A1
公开(公告)日：2009-10-01
申请号：US12411715
申请日：2009-03-26
申请人： Michael SHULTZ , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar
发明人： Michael SHULTZ , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar
IPC分类号： A61K31/496 , C07D209/04 , A61K31/404 , C12N5/00 , C07D261/06 , A61K31/42 , C07D231/10 , A61K31/415 , C07D471/02 , A61K31/437 , C07D207/00 , A61K31/40 , C07D401/02 , A61K31/4439 , C07D403/14 , A61K31/497 , A61P35/00 , A61P25/00 , A61P37/06 , A61P29/00 , A61P31/10
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R1，R2，R3，Y，Z和
如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
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公开(公告)号：US20110053925A1
公开(公告)日：2011-03-03
申请号：US12870123
申请日：2010-08-27
申请人： Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
发明人： Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
IPC分类号： A61K31/537 , C12N5/00 , A61K31/5377 , A61K31/495 , A61K31/438 , A61K31/437 , A61K31/454 , C07D498/10 , C07D413/14 , C07D413/02 , C07D295/205 , C07D471/10 , C07D471/04 , C07D401/02 , A61P25/16 , A61P25/28 , A61P9/04 , A61P7/02 , A61P19/02 , A61P9/10 , A61P35/00
CPC分类号： C07D295/205 , C07D213/74 , C07D217/22 , C07D235/30 , C07D241/42 , C07D241/50 , C07D295/155 , C07D295/185 , C07D295/26 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D491/107 , C07D491/113 , C07D498/10
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, ring A, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R1，R2，R3，环A，如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
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公开(公告)号：US20110060009A1
公开(公告)日：2011-03-10
申请号：US12870186
申请日：2010-08-27
申请人： Clinton A. BROOKS , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Gang LIU , Michael SHULTZ
发明人： Clinton A. BROOKS , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Gang LIU , Michael SHULTZ
IPC分类号： A61K31/4439 , C07D403/06 , A61K31/4045 , C07D401/06 , C07D401/14 , A61K31/4155 , A61K31/4192 , A61P35/00 , A61P25/28 , A61P25/16 , A61P9/00 , A61P19/02 , C12N9/99
CPC分类号： C07D403/06 , C07D401/14 , C07D403/04 , C07D498/06
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of use compounds of Formula I in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，R 4，R 5，环A和Z如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗全部或部分由脱乙酰酶介导的病理状况或病症的方法。
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公开(公告)号：US20140031399A1
公开(公告)日：2014-01-30
申请号：US14042652
申请日：2013-09-30
IPC分类号： C07C311/29 , C07D213/42 , C07C311/19
CPC分类号： C07C311/29 , A61K31/18 , C07C311/19 , C07C311/42 , C07C311/46 , C07C323/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/48 , C07D211/60 , C07D211/92 , C07D211/96 , C07D213/42 , C07D213/74 , C07D213/89 , C07D215/36 , C07D223/06 , C07D277/06 , C07D277/80 , C07D279/12 , C07D295/13 , C07D309/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D453/06 , C07D471/08 , C07D487/08
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-12 and/or MMP-13. Finally, the present invention also provides pharmaceutical composition that include the compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：所述化合物是MMP-12和/或MMP-13的抑制剂，因此可用于治疗特征为MMP-12异常活性和/ 或MMP-13。 因此，式（I）化合物可用于治疗由MMP-12和/或MMP-13介导的病症或疾病。 最后，本发明还提供包含式（I）化合物的药物组合物。
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