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1.发明授权N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease 有权N-磺酰化四氢喹啉和相关双环化合物，用于抑制RORγ活性和治疗疾病公开(公告)号：US09512111B2
公开(公告)日：2016-12-06
申请号：US13883419
申请日：2011-11-08
申请人： Gary D. Glick , Peter L. Toogood , Arthur G. Romero , Chad A. Van Huis , Thomas D. Aicher , Carl Kaub , Matthew N. Mattson , William D. Thomas , Karin A. Stein , Erik Krogh-Jespersen , Zhan Wang
发明人： Gary D. Glick , Peter L. Toogood , Arthur G. Romero , Chad A. Van Huis , Thomas D. Aicher , Carl Kaub , Matthew N. Mattson , William D. Thomas , Karin A. Stein , Erik Krogh-Jespersen , Zhan Wang
IPC分类号： C07D413/06 , C07D209/08 , C07D209/34 , C07D215/58 , C07D231/56 , C07D241/50 , C07D265/36 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04
CPC分类号： C07D413/06 , C07D209/08 , C07D209/34 , C07D215/58 , C07D231/56 , C07D241/50 , C07D265/36 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The invention provides tetrahydroquinoline and related compounds, pharmaceutical compositions, methods of inhibiting RORγ activity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders using such tetrahydroquinoline and related compounds are provided.
摘要翻译： 本发明提供了四氢喹啉及其相关化合物，药物组合物，抑制RORγ活性的方法，减少受试者中IL-17的量，以及使用这些四氢喹啉及相关化合物治疗免疫疾病和炎症性疾病。
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公开(公告)号：US20090069302A1
公开(公告)日：2009-03-12
申请号：US12160792
申请日：2007-01-19
申请人： Jerzy Ryszard Szewczyk , Christopher P. Laudeman , Thomas Dock , Zibin Chen , Anderson Evans , Yue H. Li
发明人： Jerzy Ryszard Szewczyk , Christopher P. Laudeman , Thomas Dock , Zibin Chen , Anderson Evans , Yue H. Li
IPC分类号： A61K31/551 , C07D241/04 , A61K31/495 , A61K31/18 , C07C311/16 , C07D243/08
CPC分类号： C07C311/29 , A61K31/132 , A61K31/135 , A61K31/145 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/40 , A61K31/4166 , A61K31/4184 , A61K31/422 , A61K31/4462 , A61K31/473 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/4995 , A61K31/538 , A61K31/55 , A61K31/551 , C07D207/48 , C07D211/96 , C07D223/12 , C07D233/38 , C07D241/04 , C07D241/08 , C07D241/50 , C07D243/08 , C07D263/32 , C07D265/36 , C07D295/26 , C07D319/18 , C07D321/10 , C07D401/12 , C07D405/12 , C07D487/08
摘要： The present invention relates generally to novel therapeutic compounds and AXOR 109 agonists, and processes for the manufacture and use of the same.
摘要翻译： 本发明一般涉及新型治疗化合物和AXOR 109激动剂，以及其制备和使用方法。
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公开(公告)号：US20060035884A1
公开(公告)日：2006-02-16
申请号：US11133738
申请日：2005-05-20
申请人： Martin Neitzel , Jennifer Marugg
发明人： Martin Neitzel , Jennifer Marugg
IPC分类号： C07D211/08 , A61K31/55
CPC分类号： C07D401/04 , C07D209/42 , C07D215/58 , C07D217/22 , C07D235/02 , C07D241/50 , C07D243/14 , C07D263/57 , C07D273/00 , C07D277/06 , C07D405/06 , C07D471/04 , C07D491/10
摘要： The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula I, wherein R4, R5, R6, R7, and R8, are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I as well as methods of treating cognitive disorders, including Alzheimer's disease using compounds of Formula I.
摘要翻译： 本发明提供用于治疗或预防认知障碍（例如阿尔茨海默病）的N-环磺酰氨基化合物。 特别感兴趣的化合物由式I定义，其中R 4，R 5，R 6，R 7， 和R 8，如说明书中所述。 本发明还包括包含式I化合物的药物组合物以及使用式I化合物治疗认知障碍（包括阿尔茨海默病）的方法。
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4.发明授权Photographic materials and processes comprising color-forming sulfonamidodiphenylamine dye precursors and corresponding phenazine dyes 失效摄影材料和方法，包括着色形成磺酰氨基二苯胺染料前体和相应的吩嗪染料
公开(公告)号：US4368246A
公开(公告)日：1983-01-11
申请号：US280673
申请日：1981-07-06
IPC分类号： C07D241/50 , C07D241/52 , C09B17/02 , G03C7/32 , G03C1/40 , G03C7/00
CPC分类号： C07D241/52 , C07D241/50 , C09B17/02 , G03C7/3244 , Y10S430/156
摘要： In a photographic material for producing a dye image or a dye image and silver image comprising (1) a photographic metal salt, such as photographic silver halide, and (2) a dye precursor, improved images are provided by means of a color-forming para-sulfonamidodiphenylamine dye precursor having one to two sulfonamido groups in positions ortho to the --NH-- moiety separating the two phenyl groups of the sulfonamidodiphenylamine and wherein the sulfonamidodiphenylamine, in oxidized form, intramolecularly reacts to produce a sulfonamido-substituted phenazine dye. An exposed photographic material containing the color-forming sulfonamidodiphenylamine dye precursor is processed to produce a negative phenazine dye-enhanced silver image. Alternatively, the exposed photographic material is processed to produce a positive phenazine dye image.
摘要翻译： 在用于制备染料图像或染料图像和银图像的照相材料中，包括（1）照相卤化银等照相金属盐和（2）染料前体，通过成色提供改进的图像 对 - 磺酰氨基二苯胺染料前体，其在与磺酰胺基二苯胺的两个苯基分离的-NH-部分的邻位上具有一至两个亚磺酰氨基，其中以氧化形式分子内反应的磺酰氨基二苯胺产生亚磺酰氨基取代的吩嗪染料。 处理含有着色形成磺酰氨基二苯胺染料前体的曝光的照相材料以产生阴性吩嗪染料增强的银图像。 或者，曝光的照相材料被处理以产生正吩嗪染料图像。
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公开(公告)号：US20150232465A1
公开(公告)日：2015-08-20
申请号：US14546896
申请日：2014-11-18
发明人： Kenneth W. BAIR , Torsten HERBERTZ , Goss S. KAUFFMAN , Katherine J. KAYSER-BRICKER , George P. LUKE , Matthew W. MARTIN , David S. MILLAN , Shawn E.R. SCHILLER , Adam C. TALBOT , Mark J. TEBBE
IPC分类号： C07D471/04 , A61K31/498 , C07D405/14 , C07D417/14 , C07D417/10 , C07D241/42 , C07D409/14 , C07D405/06 , C07D413/14 , C07D413/04 , C07D401/04 , C07D403/14 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D403/04
CPC分类号： C07D498/04 , A61K31/498 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D241/42 , C07D241/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
摘要翻译： 本发明涉及具有式（I）的可用于治疗癌症，炎性疾病，糖尿病和肥胖症的溴和额外末端（BET）溴结构域抑制剂：其中X，Y，Z，R 1，R 2，R 4 和R7在本文中定义。
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公开(公告)号：US20150080573A1
公开(公告)日：2015-03-19
申请号：US14552883
申请日：2014-11-25
发明人： Ian Armitage , Eric L. Elliott , Marianne Langston , Steven P. Langston , Quentin J. McCubbin , Hiro Mizutani , Matthew Stirling , Lei Zhu
IPC分类号： C07D487/04 , C07C315/04 , C07C317/50 , C07C215/44 , C07D305/08
CPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07C315/04 , C07C317/50 , C07C2601/08 , C07D211/96 , C07D213/89 , C07D241/50 , C07D295/22 , C07D305/08 , C07D471/08 , Y02P20/55
摘要： The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1S,2S,4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
摘要翻译： 本发明提供合成4-取代的（（1S，2S，4R）-2-羟基-4- {7H-吡咯并[2,3-d]嘧啶-7-基}环戊基）甲基的方法和合成中间体 氨基磺酸盐，其是E1活化酶抑制剂，并且可用于治疗细胞增殖，特别是癌症和与E1活性相关的其它病症的病症。
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公开(公告)号：US20090036678A1
公开(公告)日：2009-02-05
申请号：US12221399
申请日：2008-08-01
申请人： Ian Armitage , Eric L. Elliott , Marianne Langston , Steven P. Langston , Quentin J. McCubbin , Hirotake Mizutani , Matthew Stirling , Lei Zhu
发明人： Ian Armitage , Eric L. Elliott , Marianne Langston , Steven P. Langston , Quentin J. McCubbin , Hirotake Mizutani , Matthew Stirling , Lei Zhu
IPC分类号： C07D487/04 , C07C211/00
CPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07C315/04 , C07C317/50 , C07C2601/08 , C07D211/96 , C07D213/89 , C07D241/50 , C07D295/22 , C07D305/08 , C07D471/08 , Y02P20/55
摘要： The present invention provides processes and synthetic intermediates for the synthesis of 4-substituted ((1S,2S,4R)-2-hydroxy-4-{7H-pyrrolo[2,3-d]pyrimidin-7-yl}cyclopentyl)methyl sulfamates, which are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
摘要翻译： 本发明提供合成4-取代的（（1S，2S，4R）-2-羟基-4- {7H-吡咯并[2,3-d]嘧啶-7-基}环戊基）甲基的方法和合成中间体 氨基磺酸盐，其是E1活化酶抑制剂，并且可用于治疗细胞增殖，特别是癌症和与E1活性相关的其它病症的病症。
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8.发明申请Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase 审中-公开苯并二氮杂和苯并哌嗪类似物组蛋白脱乙酰酶抑制剂公开(公告)号：US20070155730A1
公开(公告)日：2007-07-05
申请号：US11467444
申请日：2006-08-25
申请人： Silvana Leit , Amal Wahhab , Martin Allan , David Smil , Pierre Tessier , Robert Deziel , Yves Chantigny
发明人： Silvana Leit , Amal Wahhab , Martin Allan , David Smil , Pierre Tessier , Robert Deziel , Yves Chantigny
IPC分类号： A61K31/5513 , C07D497/04 , C07D243/12 , C07D487/04
CPC分类号： C07D241/44 , C07D223/16 , C07D241/50 , C07D243/10 , C07D243/14 , C07D243/24 , C07D243/30 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D409/12 , C07D409/14
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein A, B, D, E, X1, X2, X3, X4 and n are as defined in the specification.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说，本发明提供式（I）的化合物，其中A，B，D，E，X 1，X 2，X 3， >，X 4和n如说明书中所定义。
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公开(公告)号：US20060223829A1
公开(公告)日：2006-10-05
申请号：US11392297
申请日：2006-03-28
申请人： Kathleen Aertgeerts , Nancy Brennan , Sheldon Cao , Edcon Chang , Andre Kiryanov , Yan Liu
发明人： Kathleen Aertgeerts , Nancy Brennan , Sheldon Cao , Edcon Chang , Andre Kiryanov , Yan Liu
IPC分类号： A61K31/496 , A61K31/445 , C07D241/04
CPC分类号： C07D241/38 , C07D207/48 , C07D209/08 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/76 , C07D211/96 , C07D213/70 , C07D213/74 , C07D215/04 , C07D215/42 , C07D215/58 , C07D217/02 , C07D217/06 , C07D217/08 , C07D217/22 , C07D217/24 , C07D231/18 , C07D231/56 , C07D233/42 , C07D235/26 , C07D239/14 , C07D241/08 , C07D241/50 , C07D261/10 , C07D265/36 , C07D271/12 , C07D277/56 , C07D277/58 , C07D277/62 , C07D279/16 , C07D285/14 , C07D285/16 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/62 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/10 , C07D513/04
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with hydroxysteroid dehydrogenases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自以下的化合物的羟基类固醇脱氢酶：其中变量如本文所定义。
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公开(公告)号：US20190055205A1
公开(公告)日：2019-02-21
申请号：US16034412
申请日：2018-07-13
发明人： Mingji Dai , Zhishi Ye
IPC分类号： C07D241/50 , C07D241/04 , C07D401/06 , C07D405/06 , C07D403/06 , C07D401/12 , C07D405/12 , C07D407/12 , C07F9/6509 , C07D487/04 , C07D243/08 , C07D243/10 , C07D245/02 , C07D471/04
CPC分类号： C07D241/50 , C07D241/04 , C07D243/08 , C07D243/10 , C07D245/02 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D405/12 , C07D407/12 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/650952
摘要： The present disclosure relates to novel synthetic method of making 1, 4-diazo N-heterocycles via intermolecular amphoteric diamination of allenes, and to the compounds made by the novel synthetic method.
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