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1.发明授权Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases 失效设计丝氨酸/苏氨酸激酶和酪氨酸激酶抑制剂的方法
公开(公告)号：US6162613A
公开(公告)日：2000-12-19
申请号：US25580
申请日：1998-02-18
CPC分类号： C12N9/1205 , G01N2333/9121
摘要： The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
摘要翻译： 本发明涉及通过使用这些激酶的ATP结合位点突变体设计丝氨酸/苏氨酸激酶和酪氨酸激酶抑制剂，特别是MAP激酶的方法。 本发明的方法利用突变体激酶能够以比相应的野生型激酶更大的亲和力结合其它激酶的抑制性化合物的事实。 本发明还涉及突变型激酶本身和突变型激酶与抑制性化合物的可结晶共配合物。
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2.发明授权Methods for designing inhibitors of serine/threonine kinases and tyrosine kinases 失效设计丝氨酸/苏氨酸激酶和酪氨酸激酶抑制剂的方法公开(公告)号：US06849716B1
公开(公告)日：2005-02-01
申请号：US09642749
申请日：2000-08-18
CPC分类号： C12N9/1205 , G01N2333/9121
摘要： The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
摘要翻译： 本发明涉及通过使用这些激酶的ATP结合位点突变体设计丝氨酸/苏氨酸激酶和酪氨酸激酶抑制剂，特别是MAP激酶的方法。 本发明的方法利用突变型激酶能够以比相应的野生型激酶更大的亲和力结合其它激酶的抑制性化合物的事实。 本发明还涉及突变型激酶本身和突变型激酶与抑制性化合物的可结晶共配合物。
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3.发明授权Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex 有权包含丙型肝炎病毒NS3蛋白酶结构域/ NS4A复合物的可结晶组合物公开(公告)号：US06303287B1
公开(公告)日：2001-10-16
申请号：US09257667
申请日：1999-02-25
申请人： Joseph L. Kim , Kurt A. Morgenstern , Chao Lin , Ted Fox , John A. Thomson
发明人： Joseph L. Kim , Kurt A. Morgenstern , Chao Lin , Ted Fox , John A. Thomson
IPC分类号： C12Q100
CPC分类号： G01N33/5767 , C07K14/005 , C07K2299/00 , C12N2770/24222 , C30B7/00 , C30B29/58 , G01N2333/18 , G06F19/16
摘要： The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
摘要翻译： 本发明涉及与其病毒辅因子复合的丙型肝炎病毒蛋白酶的组合物和晶体。 本发明还涉及使用丙型肝炎病毒蛋白酶与合成NS4A复合物的结构坐标来解决类似或同源蛋白质或蛋白质复合物的结构的方法。
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4.发明授权
公开(公告)号：US6153579A
公开(公告)日：2000-11-28
申请号：US731336
申请日：1996-10-18
申请人： Joseph L. Kim , Kurt A. Morgenstern , Chao Lin , Ted Fox , John A. Thomson
发明人： Joseph L. Kim , Kurt A. Morgenstern , Chao Lin , Ted Fox , John A. Thomson
IPC分类号： C07K1/00 , C07K14/18 , C07K19/00 , C30B7/00 , G01N33/576 , G06F17/30 , G06F19/16 , A61K38/16
CPC分类号： G01N33/5767 , C07K14/005 , C30B29/58 , C30B7/00 , C07K2299/00 , C12N2770/24222 , G01N2333/18 , G06F19/16
摘要： The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
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