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公开(公告)号：US20140034828A1
公开(公告)日：2014-02-06
申请号：US13956907
申请日：2013-08-01
申请人： Michael W. SENKO , Eloy R. WOUTERS
发明人： Michael W. SENKO , Eloy R. WOUTERS
CPC分类号： H01J29/58 , H01J49/062
摘要： An ion transport apparatus for a mass- or ion-mobility-spectrometer comprises: (a) a plurality of strip electrodes in a series on a fiat substrate; (b) an ion outlet aperture in the substrate disposed adjacent to a first one of the plurality of strip electrodes; (c) a cage electrode at least partially enclosing the plurality of strip electrodes and the ion outlet aperture; (d) a radio frequency (RF) voltage generator operable to supply an RF phase difference between each pair of adjacent electrodes; and (e) at least one DC voltage source operable to supply first and second DC voltages to the cage electrode and an extraction electrode and to supply respective DC bias voltages to each of the plurality of electrodes, wherein electrode strip widths of a series of the plurality of electrodes progressively increase away from the first one of the plurality of electrodes.
摘要翻译： 用于质量或离子迁移率光谱仪的离子迁移装置包括：（a）在平板基底上串联的多个条状电极; （b）所述基板中的与所述多个条形电极中的第一条相邻设置的离子出口孔; （c）至少部分地包围所述多个条状电极和所述离子出口孔的笼状电极; （d）可操作以在每对相邻电极之间提供RF相位差的射频（RF）电压发生器; 和（e）至少一个DC电压源，其可操作以向所述笼电极和引出电极提供第一和第二DC电压，并向所述多个电极中的每一个提供相应的DC偏置电压，其中一系列的电极条宽度 多个电极从多个电极中的第一个逐渐增加。
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公开(公告)号：US20110068263A1
公开(公告)日：2011-03-24
申请号：US12565598
申请日：2009-09-23
IPC分类号： H01J49/26
CPC分类号： H01J49/0445
摘要： A system for preventing backflow as part of an ion source arrangement is introduced. Such a system incorporates a novel continuous flow guide within a source, such as an API ion source. In the spray direction, the cross-sectional area that defines the first portion of the internal volume initially decreases in a convergent-like manner and thereafter increases in a divergent-like manner towards the exit opening of the source housing. Such a flow guide has been designed as an integral part of an ion source housing to provide for an optimal unidirectional flow past a sampling orifice of a mass spectrometer inlet. Accordingly, the novel design of the present invention prevents recirculation and thus minimizes carryover, chemical noise, and source turbulence and as an added benefit, enables a user to easily clean such a system during maintenance.
摘要翻译： 引入了用于防止作为离子源装置的一部分的回流的系统。 这样的系统在源内包含新颖的连续流动引导件，例如API离子源。 在喷射方向上，限定内部容积的第一部分的横截面面积首先以收敛方式减小，然后以发散方式朝向源壳体的出口开口增加。 这种流动引导件已被设计为离子源壳体的组成部分，以提供通过质谱仪入口的采样孔的最佳单向流动。 因此，本发明的新颖设计防止再循环，从而使携带，化学噪声和源湍流最小化，并且作为附加的益处，使得用户能够在维护期间容易地清洁这样的系统。
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3.发明申请公开(公告)号：US20120235056A1
公开(公告)日：2012-09-20
申请号：US13483806
申请日：2012-05-30
CPC分类号： H01J49/167 , H01J49/0018 , Y10T29/49423 , Y10T29/49433
摘要： An electrospray ion source for a mass spectrometer for generating ions of an analyte from a sample comprising the analyte dissolved in a liquid solvent comprises: an electrode receiving the sample and comprising at least a first plurality of protrusions protruding from a base, each protrusion of the at least a first plurality of protrusions having a respective tip; and a voltage source, wherein, in operation of the electrospray ion source, the sample is caused to move, in the presence of a gas or air, from the base to each protrusion tip along a respective protrusion exterior so as to form a respective stream of charged particles emitted towards an ion inlet aperture of the mass spectrometer under application of voltage applied to the electrode from the voltage source.
摘要翻译： 用于从包含溶解在液体溶剂中的分析物的样品产生分析物离子的质谱仪的电喷雾离子源包括：接收样品并包含至少从基底突出的第一多个突起的电极， 至少第一多个突起具有相应的末端; 以及电压源，其中，在电喷雾离子源的操作中，使样品在气体或空气的存在下沿着相应的突起外部从基部移动到每个突起尖端，以形成相应的流 在施加从电压源施加到电极的电压下，向质谱仪的离子入口孔发射的带电粒子。
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4.发明申请Ion Transfer Tube for a Mass Spectrometer Having a Resistive Tube Member and a Conductive Tube Member 审中-公开用于具有电阻管部件和导电管部件的质谱仪的离子转移管公开(公告)号：US20110260048A1
公开(公告)日：2011-10-27
申请号：US12765540
申请日：2010-04-22
CPC分类号： H01J49/0404
摘要： An ion transfer tube having an ion inlet and an ion outlet comprises: a first tube member comprising an electrically resistive material and having a first end comprising the ion inlet and a second end; a first electrode electrically coupled to the first tube member; a second tube member having a first end in leak-tight contact with the second end of the first tube member and a second end comprising the ion outlet; a second electrode electrically coupled to either the first tube member or the second tube member; and a heater thermally coupled to at least one of the tube members, wherein, in operation, an electrical potential difference applied between the electrodes produces an electric field within the first tube member that urges charged particles through the first tube member into the second tube member and the heater supplies heat to the charged particles within the ion transfer tube.
摘要翻译： 具有离子入口和离子出口的离子传递管包括：第一管构件，其包括电阻材料并且具有包括离子入口的第一端和第二端; 电耦合到第一管构件的第一电极; 第二管构件，其具有与第一管构件的第二端密封接触的第一端和包括离子出口的第二端; 电耦合到第一管构件或第二管构件的第二电极; 以及加热器，其耦合到所述管构件中的至少一个，其中，在操作中，施加在所述电极之间的电位差在所述第一管构件内产生电场，所述电场将带电粒子通过所述第一管构件推入所述第二管构件 并且加热器向离子传递管内的带电粒子提供热量。
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5.发明申请Apparatus and Method for a Multi-Stage Ion Transfer Tube Assembly for Use with Mass Spectrometry 有权用于质谱的多级离子转移管组件的装置和方法公开(公告)号：US20130043385A1
公开(公告)日：2013-02-21
申请号：US13656595
申请日：2012-10-19
CPC分类号： H01J49/0404 , Y10T137/8593
摘要： An apparatus and method for introducing ions into a vacuum chamber of a mass spectrometer includes producing ions in an ionization chamber of an ion source. The ions are sampled into an intermediate pressure chamber via a first ion transfer tube. In particular, the pressure within the intermediate pressure chamber is maintained at a value that exceeds a maximum pressure for being sampled into the vacuum chamber of the mass spectrometer. Some of the ions are sampled from the intermediate pressure chamber via at least a second ion transfer tube, the at least a second ion transfer tube having an outlet end that is in communication with a low-pressure chamber. In particular, the pressure within the low-pressure chamber is maintained at a value that is less than a maximum pressure for being sampled into the vacuum chamber of the mass spectrometer. Some of the ions are sampled from the low-pressure chamber into the vacuum chamber of the mass spectrometer.
摘要翻译： 将离子引入质谱仪的真空室的装置和方法包括在离子源的离子化室中产生离子。 离子通过第一离子转移管被采样到中间压力室中。 特别地，中压室内的压力保持在超过质量分析仪的真空室中的最大压力值。 一些离子通过至少一个第二离子转移管从中间压力室中取样，该至少一个第二离子转移管具有与低压室连通的出口端。 特别地，低压室内的压力保持在小于将被采样到质谱仪的真空室中的最大压力的值。 一些离子从低压室取样到质谱仪的真空室中。
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6.发明申请公开(公告)号：US20120280141A1
公开(公告)日：2012-11-08
申请号：US13550369
申请日：2012-07-16
IPC分类号： H01J27/02
CPC分类号： H01J49/167 , H01J49/068
摘要： An electrospray ion source apparatus comprises: a plurality of emitter capillaries, each comprising an internal bore for transporting a portion of a liquid sample from a source, an electrode portion for providing a first applied electric potential and an emitter tip for emitting a cloud of charged particles generated from the liquid sample portion; a counter electrode for providing a second applied electric potential different from the first applied electric potential; and at least one shield electrode disposed at least partially between the counter electrode and the emitter tip of at least one of the emitter capillaries for providing a third applied electric potential intermediate to the first and second applied electric potentials, wherein the at least one shield electrode is configured such that provision of the third applied electric potential to the at least one shield electrode minimizes electric field interference effects between the plurality of emitter capillaries.
摘要翻译： 电喷雾离子源设备包括：多个发射器毛细管，每个发射器毛细管包括用于从源极输送液体样品的一部分的内孔，用于提供第一施加电位的电极部分和用于发射带电的云的发射器尖端 从液体样品部分产生的颗粒; 用于提供不同于第一施加电位的第二施加电位的对电极; 以及至少一个屏蔽电极，至少部分地设置在所述发射极毛细管中的至少一个的所述对电极和所述发射极尖之间，用于向所述第一和第二施加电位提供中间的第三施加电位，其中所述至少一个屏蔽电极 被配置为使得向至少一个屏蔽电极提供第三施加电位使得多个发射器毛细管之间的电场干扰效应最小化。
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公开(公告)号：US20120153141A1
公开(公告)日：2012-06-21
申请号：US13333948
申请日：2011-12-21
CPC分类号： H01J49/0404 , B23H7/02 , B23H9/14
摘要： An ion transfer tube for a mass spectrometer comprises a core member and a first jacket tube member at least partially enclosing the core member and providing one or more channels therethrough. A method of forming an ion transfer tube, comprises: providing a first jacket tube member having a length and an internal bore, the internal bore passing along the length and defining an interior surface of circular cross section; removing at least one portion of the first jacket tube member adjacent to the interior surface so as to form at least one groove, channel, slot, recess or embayment of or in the interior surface; and providing a core member within the bore of the jacket tube member such that remnant portions of the interior surface of circular cross section mate against portions of an exterior surface of the core member.
摘要翻译： 用于质谱仪的离子传递管包括芯构件和至少部分地包围芯构件并且提供穿过其中的一个或多个通道的第一护套管构件。 一种形成离子转移管的方法，包括：提供具有长度和内孔的第一套管构件，所述内孔沿着所述长度通过并限定圆形横截面的内表面; 移除与所述内表面相邻的所述第一套管构件的至少一部分，以便形成所述内表面中或所述内表面中的至少一个凹槽，通道，槽，凹槽或沉积物; 并且在所述护套管构件的所述孔内提供芯构件，使得所述圆形横截面的内表面的残留部分与所述芯构件的外表面的部分配合。
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8.发明申请Ion Transfer Tube Having Single or Multiple Elongate Bore Segments and Mass Spectrometer System 有权具有单个或多个细长孔径和质谱仪系统的离子转移管公开(公告)号：US20120043460A1
公开(公告)日：2012-02-23
申请号：US12858726
申请日：2010-08-18
CPC分类号： H01J49/0404
摘要： An ion transfer tube for a mass spectrometer comprises a tube member having an inlet end and an outlet end; and at least one bore extending through the tube member from the inlet end to the outlet end, the at least one bore having a non-circular cross section. A method of forming an ion transfer tube comprises the steps of providing a tube member having a length and an internal bore, the internal bore having a wall of circular cross section; and etching or eroding portions of the tube member adjacent to the wall so as to form an enlarged bore having a non-circular cross section.
摘要翻译： 用于质谱仪的离子转移管包括具有入口端和出口端的管构件; 以及至少一个孔，其从所述入口端延伸到所述管构件到所述出口端，所述至少一个孔具有非圆形横截面。 形成离子转移管的方法包括以下步骤：提供具有长度和内孔的管构件，所述内孔具有圆形横截面的壁; 并且蚀刻或侵蚀与壁相邻的管构件的部分，以便形成具有非圆形横截面的扩大孔。
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9.发明申请公开(公告)号：US20110147576A1
公开(公告)日：2011-06-23
申请号：US12642573
申请日：2009-12-18
CPC分类号： H01J49/167
摘要： An electrospray ion source comprises a source of analyte-bearing liquid; a source of sheath gas; a plurality of liquid conduits, each configured so as to receive a portion of the analyte-bearing liquid; at least one electrode associated with the plurality of liquid conduits for producing electrospray emission of charged droplets from an outlet of each of the liquid conduits; a power supply electrically coupled to the at least one electrode for maintaining the at least one electrodes at an electrical potential; and either one or a plurality of sheath gas conduits, each sheath gas conduit comprising an inlet configured to receive sheath gas and an outlet configured to emit a sheath gas flow that circumferentially surrounds, in at least two dimensions, a portion of the emitted charged droplets.
摘要翻译： 电喷雾离子源包括含分析物的液体源; 鞘气源; 多个液体导管，每个液体导管被构造成容纳一部分含分析物的液体; 与所述多个液体导管相关联的至少一个电极，用于从每个液体导管的出口产生带电液滴的电喷雾; 电耦合到所述至少一个电极的电源，用于将所述至少一个电极保持在电位; 以及一个或多个护套气体管道，每个护套气体导管包括构造成接纳护套气体的入口和被配置为发射护套气体流的出口，其在至少两个维度上周向地围绕所发射的带电液滴的一部分 。
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