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公开(公告)号：US08785847B2
公开(公告)日：2014-07-22
申请号：US13396982
申请日：2012-02-15
CPC分类号： H01J49/063 , H01J49/062
摘要： A mass spectrometer having an ion guide with an axial field is described. The ion guide includes electrodes with longitudinally extending gaps and inserts configured to be proximate to the gaps.
摘要翻译： 描述了具有轴向场的离子导向器的质谱仪。 离子导向器包括具有纵向延伸的间隙的电极和构造成靠近间隙的插入件。
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2.发明申请Ion Interface Device Having Multiple Confinement Cells And Methods Of Use Thereof 有权具有多个限制性细胞的离子界面装置及其使用方法公开(公告)号：US20130105681A1
公开(公告)日：2013-05-02
申请号：US13287849
申请日：2011-11-02
CPC分类号： H01J49/0045 , H01J49/009 , H01J49/0481 , H01J49/06 , H01J49/4295
摘要： A device and associated method are disclosed for interfacing an ion trap to a pulsed mass analyzer (such as a time-of-flight analyzer) in a mass spectrometer. The device includes a plurality of separate confinement cells and structures for directing ions into a selected one of the confinement cells. Ions are ejected from the ion trap in a series of temporally successive ion packets. Each ion packet (which may consist of ions of like mass-to-charge ratio), is received by the ion interface device, fragmented to form product ions, and then stored and cooled in the selected confinement cell. Storage and cooling of the ion packet occurs concurrently with the receipt and storage of at least one later-ejected ion packet. After a predetermined cooling period, the ion packet is released to the mass analyzer for acquisition of a mass spectrum.
摘要翻译： 公开了一种用于在质谱仪中将离子阱与脉冲质量分析器（例如飞行时间分析器）接口的装置和相关方法。 该装置包括多个单独的约束单元和用于将离子引导到选定的约束单元中的结构。 离子从离子阱排出一系列时间上连续的离子包。 每个离子包（其可以由具有类似质荷比的离子组成）被离子界面装置接收，碎片化以形成产物离子，然后在选定的限制电池中储存和冷却。 离子包的存储和冷却与至少一个稍后排出的离子包的接收和存储同时发生。 在预定的冷却时间之后，离子包被释放到质量分析器以获取质谱。
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3.发明授权Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions 失效通过基质簇离子的陷阱光解作用减少MALDI质谱仪中的化学噪声公开(公告)号：US07351955B2
公开(公告)日：2008-04-01
申请号：US11233825
申请日：2005-09-09
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0059
摘要： A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of a linear ion trap in which analyte ions and matrix cluster ions are confined. The radiation beam has a wavelength that is strongly absorbed by the matrix cluster ions. The absorption of radiation by the matrix cluster ions produces dissociation of the matrix cluster ion into fragments having mass-to-charge ratios that lie below a mass-to-charge ratio range of interest. Thus, chemical noise associated with matrix cluster ions is reduced or eliminated.
摘要翻译： MALDI质谱仪包括辐射源，例如气体或固体激光器，其发射沿着线性离子阱的中心轴引导的辐射束（通常在UV或IR波长），其中分析物离子和基质簇 离子被限制。 辐射束具有被基质簇离子强烈吸收的波长。 基质簇离子对辐射的吸收会导致基质簇离子离解成具有低于感兴趣的质荷比范围的质荷比的片段。 因此，减少或消除与基质簇离子相关的化学噪声。
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公开(公告)号：US20080073497A1
公开(公告)日：2008-03-27
申请号：US11485055
申请日：2006-07-11
IPC分类号： B01D59/44
CPC分类号： H01J49/423 , H01J49/4225 , H01J49/427 , H01J49/4295
摘要： A method and apparatus are provided for operating a linear ion trap. A linear ion trap configuration is provided that allows for increased versatility in functions compared to a conventional three-sectioned linear ion trap. In operation, the linear ion trap provides multiple segments, the segments spatially portioning an initial population of ions into at least a first and a second ion population. Each segment is effectively independent and ions corresponding to the first ion population are able to be manipulated independently from ions corresponding to ions corresponding to the second ion population; the ions having been generated by an ion source under the same conditions. The ions can then be expelled from the ion trap.
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公开(公告)号：US06963066B2
公开(公告)日：2005-11-08
申请号：US10456372
申请日：2003-06-05
CPC分类号： H01J49/164 , H01J49/063
摘要： Ion source assemblies for generating ions for laser desorption mass spectrometry. An ion source assembly includes a target for receiving analyte samples and a plurality of rods. The rods define an interior volume having an axis extending away from a surface of the target for transporting ions. One or more of the rods include an aperture defining an opening through a cross-section of the rod. The aperture is configured such that a laser beam can pass through the aperture to irradiate a location on the target surface to generate ions from an analyte sample deposited at the location.
摘要翻译： 用于生成离子用于激光解吸质谱的离子源组件。 离子源组件包括用于接收分析物样品和多个棒的靶。 杆限定内部体积，其具有远离靶的表面延伸的轴线，用于输送离子。 杆中的一个或多个包括限定穿过杆的横截面的开口的孔。 孔被构造成使得激光束可以通过孔径以照射目标表面上的位置以从沉积在该位置处的分析物样品产生离子。
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6.发明授权Method and apparatus of mass-correlated pulsed extraction for a time-of-flight mass spectrometer 有权飞行时间质谱仪质量相关脉冲提取的方法和装置公开(公告)号：US06518568B1
公开(公告)日：2003-02-11
申请号：US09589480
申请日：2000-06-07
IPC分类号： H01J4840
CPC分类号： H01J49/40
摘要： A time-of-flight mass spectrometer includes a sample holder for a sample and an ionizer for ionizing the sample to form ions. A first element is spaced downstream from the sample holder, a second element is spaced downstream from the first element, and a drift region is downstream of the second element. An electric field is established between the sample holder and the first element at a time subsequent to ionizing the sample in order to extract the ions. A time-dependent and mass-correlated electric field is established between at least one of: (a) the first element and the second element, and (b) the sample holder and the first element. In turn, a detector detects the ions.
摘要翻译： 飞行时间质谱仪包括用于样品的样品保持器和用于电离样品以形成离子的离子发生器。 第一元件与样品保持器的下游间隔开，第二元件与第一元件的下游间隔开，漂移区域位于第二元件的下游。 在电离样品之后的时间，在样品保持器和第一元件之间建立电场以提取离子。 在（a）第一元件和第二元件中的至少一个以及（b）样品保持器和第一元件中的至少一个之间建立时间依赖和质量相关的电场。 反过来，检测器检测离子。
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公开(公告)号：US08581177B2
公开(公告)日：2013-11-12
申请号：US13084304
申请日：2011-04-11
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , G01N27/622 , H01J49/06
摘要： A novel high ion storage/ion mobility separation mass spectrometer that provides for a high duty cycle of operation is presented herein. In particular, the example embodiments, as disclosed herein, provides for a high ion storage/ion mobility instrument that beneficially includes a two-dimensional (2D) plurality of adjacently arranged ion confinement channels to provide a high storage bank of a desired mass range of ions. Such ions, via ion mobility transport, are separated into smaller fractions of an overall mass window into desired confinement regions of the disclosed 2D confinement channels and thereafter transferred out in a manner so as to enable the aforementioned novel high-duty cycle of sequential operation.
摘要翻译： 本文介绍了一种提供高占空比操作的新型高离子存储/离子迁移分离质谱仪。 特别地，如本文所公开的示例性实施例提供了一种高离子存储/离子迁移仪器，其有利地包括二维（2D）多个相邻布置的离子限制通道，以提供期望质量范围的高存储体 离子。 通过离子迁移率传输将这样的离子分离成整个质量窗口的较小部分，形成所公开的二维限制通道的所需限制区域，然后以这样的方式转出，以便能够实现上述新型的连续操作的高占空比。
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公开(公告)号：US20130206973A1
公开(公告)日：2013-08-15
申请号：US13396982
申请日：2012-02-15
CPC分类号： H01J49/063 , H01J49/062
摘要： A mass spectrometer having an ion guide with an axial field is described. The ion guide includes electrodes with longitudinally extending gaps and inserts configured to be proximate to the gaps.
摘要翻译： 描述了具有轴向场的离子导向器的质谱仪。 离子导向器包括具有纵向延伸的间隙的电极和构造成靠近间隙的插入件。
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9.发明申请公开(公告)号：US20120280141A1
公开(公告)日：2012-11-08
申请号：US13550369
申请日：2012-07-16
IPC分类号： H01J27/02
CPC分类号： H01J49/167 , H01J49/068
摘要： An electrospray ion source apparatus comprises: a plurality of emitter capillaries, each comprising an internal bore for transporting a portion of a liquid sample from a source, an electrode portion for providing a first applied electric potential and an emitter tip for emitting a cloud of charged particles generated from the liquid sample portion; a counter electrode for providing a second applied electric potential different from the first applied electric potential; and at least one shield electrode disposed at least partially between the counter electrode and the emitter tip of at least one of the emitter capillaries for providing a third applied electric potential intermediate to the first and second applied electric potentials, wherein the at least one shield electrode is configured such that provision of the third applied electric potential to the at least one shield electrode minimizes electric field interference effects between the plurality of emitter capillaries.
摘要翻译： 电喷雾离子源设备包括：多个发射器毛细管，每个发射器毛细管包括用于从源极输送液体样品的一部分的内孔，用于提供第一施加电位的电极部分和用于发射带电的云的发射器尖端 从液体样品部分产生的颗粒; 用于提供不同于第一施加电位的第二施加电位的对电极; 以及至少一个屏蔽电极，至少部分地设置在所述发射极毛细管中的至少一个的所述对电极和所述发射极尖之间，用于向所述第一和第二施加电位提供中间的第三施加电位，其中所述至少一个屏蔽电极 被配置为使得向至少一个屏蔽电极提供第三施加电位使得多个发射器毛细管之间的电场干扰效应最小化。
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公开(公告)号：US07851745B2
公开(公告)日：2010-12-14
申请号：US12334313
申请日：2008-12-12
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： A high field asymmetric waveform ion mobility spectrometer (FAIMS) includes at least two focusing electrodes that are separated one from the other by a gap, which decreases in width along a direction of ion flow. Within the gap is disposed an electrode assembly including a first electrode and a second electrode, approximately flat surfaces of the first and second electrodes facing one another so as to define a space of approximately uniform thicknesses therebetween. During use electrical signals are applied via an electrical contact on at least one of the first electrode and the second electrode, and on each one of the at least two focusing electrodes. The electrical signals are for establishing electrode electric field conditions within the space between the first electrode and the second, for selectively transmitting ions therethrough and for directing the selectively transmitted ions in a direction away from one of the at least two focusing electrodes and toward a central portion of the space.
摘要翻译： 高场非对称波形离子迁移谱仪（FAIMS）包括至少两个聚焦电极，它们彼此间隔开一个沿离子流方向减小宽度的间隙。 在间隙内设置包括第一电极和第二电极的电极组件，第一电极和第二电极的大致平坦表面彼此面对，以便在其间限定大致均匀厚度的空间。 在使用期间，电信号经由第一电极和第二电极中的至少一个以及至少两个聚焦电极中的每一个上的电接触施加。 电信号用于在第一电极和第二电极之间的空间内建立电极电场条件，用于选择性地将离子透射通过其中，并且用于沿着远离至少两个聚焦电极之一的方向引导选择性透射的离子，并且朝向中心 部分空间。
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