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公开(公告)号：US20110217334A1
公开(公告)日：2011-09-08
申请号：US12674195
申请日：2008-06-30
申请人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号： A61K39/35 , C07K14/415 , C12N15/63 , C07H21/00 , A61P37/08
CPC分类号： C07K14/415
摘要： The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v Ia.
摘要翻译： 本发明涉及由Bet v 1a或与Bet v Ia具有至少40％同一性的变应原组成的低变应原性分子，其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其 与Bet v Ia具有至少40％同一性的变应原的相应区域。
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公开(公告)号：US09040054B2
公开(公告)日：2015-05-26
申请号：US12674195
申请日：2008-06-30
申请人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
发明人： Michael Wallner , Barbara Bohle , Martin Himly , Nicole Wopfner , Gabriele Gadermaier , Matthias Egger , Peter Lackner , Fatima Ferreira , Michael Hauser
IPC分类号： A61K36/00 , A61K39/00 , A61K39/35 , A61K39/36 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K14/415
CPC分类号： C07K14/415
摘要： The present invention relates to a hypoallergenic molecule consisting of Bet v Ia or an allergen having at least 40% identity to Bet v Ia comprising mutations of at least four amino acid residues in the region of amino acids 100 to 125 of Bet v Ia or its corresponding region of the allergen having at least 40% identity to Bet v 1a.
摘要翻译： 本发明涉及由Bet v 1a或与Bet v Ia具有至少40％同一性的变应原组成的低变应原性分子，其包含Bet v Ia的氨基酸100至125的区域中至少四个氨基酸残基的突变或其 与Bet v 1a具有至少40％同一性的变应原的相应区域。
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公开(公告)号：US20140242668A1
公开(公告)日：2014-08-28
申请号：US14131593
申请日：2012-07-09
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C12Y402/02
摘要： The present invention relates to a variant of a mature polysaccharide lyase having a beta helix structure, wherein said variant comprises an N- and/or C-terminal truncation and consists essentially of at least 90% of the beta helix structure of the mature polysaccharide lyase.
摘要翻译： 本发明涉及具有β螺旋结构的成熟多糖裂解酶的变体，其中所述变体包含N-和/或C-末端截短并且基本上由至少90％的成熟多糖裂解酶的β螺旋结构组成 。
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4.发明授权公开(公告)号：US06984726B1
公开(公告)日：2006-01-10
申请号：US09647234
申请日：1999-03-25
申请人： Fatima Ferreira , Klaus Richter , Martin Himly , Edwin Engel , Christof Ebner , Michael Breitenbach , Dietrich Kraft
发明人： Fatima Ferreira , Klaus Richter , Martin Himly , Edwin Engel , Christof Ebner , Michael Breitenbach , Dietrich Kraft
IPC分类号： C07H21/04
CPC分类号： C07K14/415 , A61K39/00
摘要： The invention relates to DNA molecules which code for the allergen Art v 1 or isoforms thereof, the sequence of the allergen, a method for the production of an Art v 1 molecule, a vector and a transformed host cell.
摘要翻译： 本发明涉及编码变应原Art v 1或其同工型的DNA分子，变应原的序列，Art v 1分子的生产方法，载体和转化的宿主细胞。
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5.发明授权Isolation of allergen-specific immunoglobulin genes from human B-cells from atopy sufferers 有权从特应性患者的人B细胞中分离变应原特异性免疫球蛋白基因公开(公告)号：US08399200B2
公开(公告)日：2013-03-19
申请号：US11597492
申请日：2005-05-25
申请人： Gernot Achatz , Michael Huhn , Rainer Fischer , Fatima Ferreira , Elke Luger , Michael Stöcker , Stefan Barth , Torsten Klockenbring
发明人： Gernot Achatz , Michael Huhn , Rainer Fischer , Fatima Ferreira , Elke Luger , Michael Stöcker , Stefan Barth , Torsten Klockenbring
IPC分类号： C12Q1/68
CPC分类号： C12N15/1034 , C07K16/16 , C07K2317/622
摘要： A process is disclosed which enables the establishing of comprehensive immunoglobulin-specific reaction profiles of subjects with disorders of the immune function by the individual V gene repertoire of Ig-expressing B cells. The process comprises the isolation of B cells from body fluids, the isolation of individual B cells and their genetic material, the amplification of nucleic acids coding the variable regions of an antibody expressed by a B cell, the recombinant preparation of antibodies by expressing the amplificates, and the determination of the binding capability of the recombinant antibody to antigens.
摘要翻译： 公开了一种方法，其能够通过单克隆抗体表达B细胞的V基因库，建立具有免疫功能障碍的受试者的综合免疫球蛋白特异性反应谱。 该方法包括从体液中分离B细胞，分离个体B细胞及其遗传物质，编码由B细胞表达的抗体的可变区的核酸的扩增，通过表达扩增产物的重组抗体制备 ，以及重组抗体对抗原的结合能力的测定。
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6.发明申请Isolation Of Allergen-Specific Immunoglobulin Genes From Human B-Cells From Atopy Sufferers 有权从特应性受试者的人类B细胞中分离过敏原特异性免疫球蛋白基因公开(公告)号：US20100035241A1
公开(公告)日：2010-02-11
申请号：US11597492
申请日：2005-05-25
申请人： Gernot Achatz , Michael Huhn , Rainer Fischer , Fatima Ferreira , Elke Luger , Michael Stöcker , Stefan Barth , Torsten Klockenbring
发明人： Gernot Achatz , Michael Huhn , Rainer Fischer , Fatima Ferreira , Elke Luger , Michael Stöcker , Stefan Barth , Torsten Klockenbring
CPC分类号： C12N15/1034 , C07K16/16 , C07K2317/622
摘要： A process is disclosed which enables the establishing of comprehensive immunoglobulin-specific reaction profiles of subjects with disorders of the immune function by the individual V gene repertoire of Ig-expressing B cells. The process comprises the isolation of B cells from body fluids, the isolation of individual B cells and their genetic material, the amplification of nucleic acids coding the variable regions of an antibody expressed by a B cell, the recombinant preparation of antibodies by expressing the amplificates, and the determination of the binding
摘要翻译： 公开了一种方法，其能够通过单克隆抗体表达B细胞的V基因库，建立具有免疫功能障碍的受试者的综合免疫球蛋白特异性反应谱。 该方法包括从体液中分离B细胞，分离个体B细胞及其遗传物质，编码由B细胞表达的抗体的可变区的核酸的扩增，通过表达扩增产物的重组抗体制备 ，并确定绑定
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公开(公告)号：US09360486B2
公开(公告)日：2016-06-07
申请号：US12526143
申请日：2008-02-13
申请人： Fatima Ferreira , Barbara Bohle , Beatrice Jahn-Schmid , Nicole Wopfner , Georg Schmidt , Christof Ebner
发明人： Fatima Ferreira , Barbara Bohle , Beatrice Jahn-Schmid , Nicole Wopfner , Georg Schmidt , Christof Ebner
IPC分类号： A61K38/00 , A61K38/04 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , G01N33/68 , C07K14/415
CPC分类号： A61K39/36 , C07K14/415 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to a peptide derived from the ragweed pollen allergen Amb a (1) and comprising (6 to 50) amino acid residues and pharmaceutical preparations comprising said peptide and uses thereof.
摘要翻译： 本发明涉及来自豚草花粉变应原Amb a（1）并且包含（6-50个）氨基酸残基的肽和包含所述肽的药物制剂及其用途。
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公开(公告)号：US20100104606A1
公开(公告)日：2010-04-29
申请号：US12526143
申请日：2008-02-13
申请人： Fatima Ferreira , Barbara Bohle , Beatrice Jahn-Schmid , Nicole Wopfner , Georg Schmidt , Christoff Ebner
发明人： Fatima Ferreira , Barbara Bohle , Beatrice Jahn-Schmid , Nicole Wopfner , Georg Schmidt , Christoff Ebner
CPC分类号： A61K39/36 , C07K14/415 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to a peptide derived from the ragweed pollen allergen Amb a (1) and comprising (6 to 50) amino acid residues and pharmaceutical preparations comprising said peptide and uses thereof.
摘要翻译： 本发明涉及来自豚草花粉变应原Amb a（1）并且包含（6-50个）氨基酸残基的肽和包含所述肽的药物制剂及其用途。
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公开(公告)号：US20050215766A1
公开(公告)日：2005-09-29
申请号：US10517052
申请日：2003-06-03
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/36 , A61K39/395 , A61P37/08 , C07K1/22 , C07K14/415 , C07K16/16 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/29 , C12P21/02 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/415
摘要： The present invention relates to a 40.9 kDa allergen from mugwort pollen, to polypeptides derived therefrom and polynucleotides encoding the same. The invention further pertains to antibodies directed against the allergen and to the use of the materials described for the manufacture of a medicament for the treatment or prevention of an allergic disorder.
摘要翻译： 本发明涉及从艾蒿花粉获得的40.9kDa的变应原，以及由其衍生的多肽和编码其的多核苷酸。 本发明还涉及针对变应原的抗体和所述用于制备用于治疗或预防过敏性疾病的药物所述的材料的用途。
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