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    Micronized opioid compositions having a specific particle size distribution
    2.
    发明授权
    Micronized opioid compositions having a specific particle size distribution 有权
    具有特定粒度分布的微粉化阿片样物质组合物

    公开(公告)号：US09339463B2

    公开(公告)日：2016-05-17

    申请号：US12329318

    申请日：2008-12-05

    申请人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su Il Yum

    发明人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su Il Yum

    IPC分类号： A61K9/14 ,  A61P25/04 ,  A61K9/16 ,  A61K31/485

    CPC分类号： A61K9/14 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/485

    摘要： Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10μ or less than or equal to 20μ are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.

    摘要翻译： 公开了包含稳定的微粉化阿片样物质颗粒的新型组合物，制剂和剂型。 示例性阿片样物质包括羟考酮，羟吗啡酮，氢可酮和氢吗啡酮，包括游离碱或盐。 公开了具有小于或等于10μ或小于或等于20μ的Dv90粒度分布的稳定的微粉化阿片样物质颗粒。 还公开了使阿片样物质微粉化以提供稳定的微粉化阿片样物质颗粒的方法。

    Formulations with hydrophobic permeation enhancers
    7.
    发明授权
    Formulations with hydrophobic permeation enhancers 失效
    疏水渗透促进剂配方

    公开(公告)号：US5629019A

    公开(公告)日：1997-05-13

    申请号：US064689

    申请日：1993-05-20

    申请人： Eun Soo Lee ,  Su Il Yum ,  Michel J. N. Cormier

    发明人： Eun Soo Lee ,  Su Il Yum ,  Michel J. N. Cormier

    IPC分类号： A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/28 ,  A61K47/36 ,  A61K9/06

    CPC分类号： A61K47/26 ,  A61K47/12 ,  A61K47/14 ,  A61K47/186 ,  A61K47/20 ,  A61K47/28 ,  A61K47/36 ,  A61K9/0014 ,  Y10S514/944 ,  Y10S514/946 ,  Y10S514/951

    摘要： This invention is directed to a novel formulation for effectively utilizing hydrophobic permeation enhancers for the increased permeability of active agents through the skin or mucosa along with reduction of the lag time between application of the active agent and attainment of a therapeutically effective agent flux, with little or no irritation to the host. The invention is directed to compositions containing a hydrophobic permeation enhancer, which permeation enhancer has been micronized and stabilized in an inert carrier such as water. These compositions can be combined with a biologically active agent to provide enhanced permeability of the active agent to the skin or mucosa.

    摘要翻译： 本发明涉及一种用于有效利用疏水性渗透增强剂以增加活性剂通过皮肤或粘膜的渗透性的新型制剂，同时减少施用活性剂之间的滞后时间并获得治疗有效的药剂通量 或对主机没有刺激。 本发明涉及含有疏水渗透增强剂的组合物，该渗透增强剂已经在惰性载体如水中微粉化并稳定。 这些组合物可与生物活性剂组合以提供活性剂对皮肤或粘膜的增强的渗透性。

    Cartridge for liquid infusion apparatus
    9.
    发明授权
    Cartridge for liquid infusion apparatus 失效
    液体输液装置用墨盒

    公开(公告)号：US4140117A

    公开(公告)日：1979-02-20

    申请号：US798507

    申请日：1977-05-19

    申请人： Richard G. Buckles ,  Seymour Hoff ,  Sharon Kehr ,  Su Il Yum

    发明人： Richard G. Buckles ,  Seymour Hoff ,  Sharon Kehr ,  Su Il Yum

    IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M5/152 ,  A61M5/155 ,  A61J7/00

    CPC分类号： A61M5/152 ,  A61M5/145 ,  A61M5/155 ,  A61M2005/14204 ,  Y10S128/12

    摘要： A removable cartridge that is used in combination with a liquid drug infusion apparatus that comprises a housing that defines an inlet and outlet and has a recess for receiving the cartridge, a confined flow passageway extending between the inlet and outlet, and a conduit extending from the outlet to the infusion site. The removable cartridge includes: a hollow shell that fits within the recess, is adapted to contain the liquid drug, and has an outlet that is adapted to communicate with the inlet of the housing and the drug contained within the shell; pressure means within the shell that maintains a constant, positive pressure on the drug; and lock means on the shell that engages the housing to reversibly lock the cartridge within the recess.

    摘要翻译： 一种与液体药物输注装置组合使用的可拆卸的药筒，其包括限定入口和出口的壳体，并且具有用于接收药筒的凹部，在入口和出口之间延伸的限制流动通道和从所述入口和出口延伸的导管 出口到输液部位。 所述可拆卸的盒包括：适合于所述凹槽内的中空壳，适于容纳所述液体药物，并具有适于与所述壳体的入口和所述壳体内的药物连通的出口; 壳内的压力意味着对药物保持恒定的正压力; 以及壳体上的锁定装置，其与壳体接合以将盒可逆地锁定在凹部内。