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11 条记录 (耗时 0.016 秒)

    Micronized opioid compositions having a specific particle size distribution
    1.
    发明授权
    Micronized opioid compositions having a specific particle size distribution 有权
    具有特定粒度分布的微粉化阿片样物质组合物

    公开(公告)号：US09339463B2

    公开(公告)日：2016-05-17

    申请号：US12329318

    申请日：2008-12-05

    申请人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su Il Yum

    发明人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su Il Yum

    IPC分类号： A61K9/14 ,  A61P25/04 ,  A61K9/16 ,  A61K31/485

    CPC分类号： A61K9/14 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/485

    摘要： Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10μ or less than or equal to 20μ are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.

    摘要翻译： 公开了包含稳定的微粉化阿片样物质颗粒的新型组合物，制剂和剂型。 示例性阿片样物质包括羟考酮，羟吗啡酮，氢可酮和氢吗啡酮，包括游离碱或盐。 公开了具有小于或等于10μ或小于或等于20μ的Dv90粒度分布的稳定的微粉化阿片样物质颗粒。 还公开了使阿片样物质微粉化以提供稳定的微粉化阿片样物质颗粒的方法。

    Vaccine adjuvant
    5.
    发明授权
    Vaccine adjuvant 失效
    疫苗佐剂

    公开(公告)号：US5376369A

    公开(公告)日：1994-12-27

    申请号：US477281

    申请日：1990-02-08

    申请人： Anthony C. Allison ,  Noelene E. Byars ,  Cherng-Chyi Fu ,  Deborah M. Lidgate ,  Philip L. Felgner ,  Linda C. Foster ,  William A. Lee

    发明人： Anthony C. Allison ,  Noelene E. Byars ,  Cherng-Chyi Fu ,  Deborah M. Lidgate ,  Philip L. Felgner ,  Linda C. Foster ,  William A. Lee

    IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K39/39

    CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K2039/55511 ,  A61K2039/5555 ,  A61K2039/55566 ,  Y10S514/885 ,  Y10S530/806 ,  Y10S530/815

    摘要： This invention is directed to an adjuvant composition in the form of an emulsion which is comprised of an emulsion-forming amount of a non-toxic tetra-polyol or of a POP-POE block polymer and an immunopotentiating amount of a muramyldipeptide of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, where R and R.sub.1 are each independently H or acyl of 1 to 22 carbon atoms, R.sub.2 is optionally substituted alkyl or optionally substituted aryl, R.sub.3 is H, alkyl, or aryl, R.sub.4 is H or lower alkyl, X is L-alanyl, L-.alpha.-aminobutyryl, L-arginyl, L-asparginyl, L-aspartyl, L-cysteinyl, L-glutaminyl, L-glutamyl, glycyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-lysyl, L-methionyl, L-ornithinyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tyrosyl, L-tryptophanyl, or L-valyl, and Y is D-glutamine, D-isoglutamine or D-isoasparagine. This invention is also directed to a vaccine containing an antigen and an adjuvant composition of the invention. This invention is also directed to a process of preparing an adjuvant composition and a vaccine of the invention. This invention is also directed to a kit for extemporaneous preparation of an adjuvant composition and a vaccine of the invention.

    摘要翻译： 本发明涉及一种乳液形式的佐剂组合物，其由乳液形成量的无毒四元多元醇或POP-POE嵌段聚合物和免疫增强量的下式的胞壁酰二肽组成： 其中R 1和R 1各自独立地为H或1至22个碳原子的酰基，R 2为任选取代的烷基或任选取代的芳基，R 3为H，烷基或芳基，R 4为 是H或低级烷基，X是L-丙氨酰，L-α-氨基丁酰基，L-精氨酰基，L-天冬氨酰基，L-天冬氨酰基，L-半胱氨酰基，L-谷氨酰胺基，L-谷氨酰基，甘氨酰基，L-组氨酰基， 羟基甲酰基，L-异亮氨酰基，L-亮氨酰基，L-赖氨酰基，L-甲硫氨酰，L-鸟氨酸，L-苯丙氨酰，L-脯氨酰基，L-丝氨酰，L-苏氨酰，L-酪氨酰，L-色氨酸或L-缬氨酰 ，Y是D-谷氨酰胺，D-异谷氨酰胺或D-异天竺葵碱。 本发明还涉及含有本发明的抗原和佐剂组合物的疫苗。 本发明还涉及制备本发明的佐剂组合物和疫苗的方法。 本发明还涉及用于临时制备本发明的佐剂组合物和疫苗的试剂盒。

    Contact lens rejuvenating solution
    6.
    发明授权
    Contact lens rejuvenating solution 失效
    隐形眼镜复原解决方案

    公开(公告)号：US4388229A

    公开(公告)日：1983-06-14

    申请号：US317656

    申请日：1981-11-02

    申请人： Cherng-Chyi Fu

    发明人： Cherng-Chyi Fu

    IPC分类号： A61L12/08 ,  C11D1/66 ,  C11D3/00 ,  C11D3/02 ,  C11D3/37 ,  C11D1/72 ,  C11D7/48

    CPC分类号： C11D3/046 ,  A61L12/08 ,  C11D1/74 ,  C11D3/0078 ,  C11D3/3773 ,  C11D3/378

    摘要： A solution for removing occluded and adsorbed chemicals, such as cationic preservating agents, anionic preserving agents and mixtures thereof, from contact lenses which comprises a nonionic surfactant; a cationic ion exchange resin, an anionic ion exchange resin, or mixtures thereof; water; and optionally sodium chloride. Such solutions are useful to reduce and prevent irritation of the eye of the contact lens wearer.

    摘要翻译： 用于从包含非离子表面活性剂的隐形眼镜中除去封闭和吸附的化学物质的溶液，例如阳离子防腐剂，阴离子防腐剂及其混合物; 阳离子离子交换树脂，阴离子离子交换树脂或其混合物; 水; 和任选的氯化钠。 这样的解决方案对于减少和防止隐形眼镜佩戴者的眼睛的刺激是有用的。

    MICRONIZED OPIOID COMPOSITIONS, FORMULATIONS AND DOSAGE FORMS AND METHODS OF MAKING SAME
    10.
    发明申请
    MICRONIZED OPIOID COMPOSITIONS, FORMULATIONS AND DOSAGE FORMS AND METHODS OF MAKING SAME 审中-公开
    微量制剂组合物，制剂和剂型及其制备方法

    公开(公告)号：US20090169631A1

    公开(公告)日：2009-07-02

    申请号：US12329318

    申请日：2008-12-05

    申请人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su ll Yum

    发明人： Michael Zamloot ,  Cherng-chyi Fu ,  De-Hwa Chao ,  Andrei Blasko ,  Su ll Yum

    IPC分类号： A61K9/14 ,  A61P25/04

    CPC分类号： A61K9/14 ,  A61K9/1623 ,  A61K9/1652 ,  A61K31/485

    摘要： Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10μ or less than or equal to 20μ are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.

    摘要翻译： 公开了包含稳定的微粉化阿片样物质颗粒的新型组合物，制剂和剂型。 示例性阿片样物质包括羟考酮，羟吗啡酮，氢可酮和氢吗啡酮，包括游离碱或盐。 公开了具有小于或等于10mu或小于或等于20mu的Dv90粒度分布的稳定的微粉化阿片样物质颗粒。 还公开了使阿片样物质微粉化以提供稳定的微粉化阿片样物质颗粒的方法。