利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.055 秒)

    Bacterial mass production of taxanes and paclitaxel
    1.
    发明授权
    Bacterial mass production of taxanes and paclitaxel 失效
    紫杉烷和紫杉醇的细菌大量生产

    公开(公告)号：US6030818A

    公开(公告)日：2000-02-29

    申请号：US995960

    申请日：1997-12-22

    申请人： Michel Page ,  Nathalie Landry ,  Maurice Boissinot ,  Marie-Claude Helie ,  Mario Harvey ,  Martin Gagne

    发明人： Michel Page ,  Nathalie Landry ,  Maurice Boissinot ,  Marie-Claude Helie ,  Mario Harvey ,  Martin Gagne

    IPC分类号： C12P15/00 ,  C12P17/02 ,  C12N1/20

    CPC分类号： C12P17/02 ,  C12P15/00

    摘要： The present invention relates to a method of obtaining different biologically pure cultures of bacteria isolated from different species of Taxus such as Taxus canadensis. T. brevifolia, T. baccata, T. cuspidata, and T. hunnewelliana, wherein the bacteria produce in vitro taxanes and paclitaxel, and wherein the bacteria are of the genus Sphingomonas, Bacillus, Pantoea or Curtobacterium. Also, the present invention relates to a method of a bacterial mass production of at least one taxane or paclitaxel. There is also disclosed a novel bacterial taxane. The present invention also relates to the use of different biologically pure cultures of bacteria isolated from different species of Taxus, wherein the bacteria are able to biotransform pro-taxanes. There is also provided a process for improving taxanes and paclitaxel production of taxanes and paclitaxel producing bacteria which include culturing bacteria in the presence of a mutagenic agent for a period a time sufficient to allow mutagenesis. There is disclosed two new mutated bacteria which have an increased yield of pro-taxane biotransformation.

    摘要翻译： 本发明涉及从不同种类的红豆杉（Taxus canadensis）分离得到的细菌的不同生物纯培养物的方法。 T. brevifolia，T.cuspidata和T. hunnewelliana，其中细菌在体外产生紫杉烷和紫杉醇，其中细菌是鞘氨醇单胞菌属，芽孢杆菌属，泛菌属或曲霉属。 另外，本发明涉及细菌大量生产至少一种紫杉烷或紫杉醇的方法。 还公开了一种新型细菌紫杉烷。 本发明还涉及从不同种类的红豆杉分离的细菌的不同生物纯培养物的用途，其中细菌能够生物转化前紫杉烷。 还提供了一种改善紫杉烷类和紫杉醇生产细菌的紫杉烷类和紫杉醇生产的方法，其包括在致突变剂存在下培养细菌足以允许诱变的时间。 已经公开了两种新的突变细菌，其具有增加的前紫杉烷生物转化产率。

    MEDICAGENIC ACID SAPONIN AND USES THEREOF
    6.
    发明申请
    MEDICAGENIC ACID SAPONIN AND USES THEREOF 审中-公开
    药用酸性痤疮及其用途

    公开(公告)号：US20090318377A1

    公开(公告)日：2009-12-24

    申请号：US12373476

    申请日：2007-07-13

    申请人： Louis-Philippe Vezina ,  Nathalie Landry ,  Joelle Pelletier ,  Sylvain Savard

    发明人： Louis-Philippe Vezina ,  Nathalie Landry ,  Joelle Pelletier ,  Sylvain Savard

    IPC分类号： A61K31/704 ,  A61P3/06

    CPC分类号： A61K31/575 ,  A23L33/105 ,  A61K31/704

    摘要： A cholesterol-lowering preparation comprising medicagenic acid saponin is disclosed. The amount of medicagenic acid saponin in the preparation is greater than 50% by weight to produce the cholesterol-lowering effect in an animal. A method of purifying a preparation of at least 30% medicagenic acid saponin is also disclosed. The preparation may be purified from alfalfa plants and used as a treatment for lowering cholesterol and triglycerides in an animal, in particular a human.

    摘要翻译： 公开了包含药用皂苷的降胆固醇制剂。 制剂中的药用植物皂苷的量大于50重量％，以在动物中产生降低胆固醇的作用。 还公开了一种纯化至少30％的药用植物皂苷的制剂的方法。 该制剂可以从苜蓿植物中纯化并用作降低动物，特别是人类中的胆固醇和甘油三酸酯的治疗剂。

    Bacterial mass production of taxanes with Erwinia
    8.
    发明授权
    Bacterial mass production of taxanes with Erwinia 失效
    用欧文氏菌的细菌大规模生产紫杉烷

    公开(公告)号：US5561055A

    公开(公告)日：1996-10-01

    申请号：US436006

    申请日：1995-05-05

    申请人： Michel Pag e ,  Nathalie Landry

    发明人： Michel Pag e ,  Nathalie Landry

    IPC分类号： C12P17/02 ,  C12N1/20

    CPC分类号： C12R1/18 ,  C12P17/02

    摘要： The present invention relates to a biologically pure culture of a novel bacteria of genus Erwinia, which is isolated from Taxus canadensis, and wherein said bacteria of genus Erwinia is characterized by the production of paclitaxel and related taxanes in a fermentative or respiratory type of metabolism from simple semi-synthetic or synthetic culture media. Also, the present invention relates to a method of bacterial mass production of paclitaxel and related taxanes which comprises the steps of: a) culturing the bacteria of genus Erwinia of the present invention in a growth-supporting nutrient medium capable of promoting growth and reproduction of said bacteria, and wherein said culturing is effected for a time sufficient to allow production of paclitaxel and related taxanes; and b) isolating said produced paclitaxel and related taxanes from said culturing medium of step a).

    摘要翻译： 本发明涉及从加拿大红豆杉分离的欧文氏菌属新型细菌的生物学纯培养物，其中所述欧文氏菌属细菌的特征在于在发酵或呼吸型新陈代谢中产生紫杉醇和相关的紫杉烷类 简单的半合成或合成培养基。 此外，本发明涉及紫杉醇和相关紫杉烷的细菌大量生产方法，其包括以下步骤：a）将本发明的欧文氏菌属细菌培养在能够促进生长和繁殖的生长支持营养培养基中 所述细菌，并且其中所述培养进行足以允许产生紫杉醇和相关紫杉烷的时间; 和b）从步骤a）的所述培养基中分离所述产生的紫杉醇和相关的紫杉烷。