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1.发明授权公开(公告)号：US08399248B2
公开(公告)日：2013-03-19
申请号：US12598563
申请日：2008-05-05
申请人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
发明人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2320/53 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.
摘要翻译： 一方面，本发明一般涉及miR-34作为生物标志物估计细胞中TP53功能的用途。 在另一方面，本发明一般涉及miR-34和siRNA在功能上和结构上与miR-34相关的多种用途，用于治疗癌症。
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2.发明申请公开(公告)号：US20110105583A1
公开(公告)日：2011-05-05
申请号：US12598563
申请日：2008-05-05
申请人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
发明人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
IPC分类号： A61K31/7052 , C12Q1/68 , C40B30/04 , C12N5/00 , A61P35/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2320/53 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.
摘要翻译： 一方面，本发明一般涉及miR-34作为生物标志物估计细胞中TP53功能的用途。 在另一方面，本发明一般涉及miR-34和siRNA在功能上和结构上与miR-34相关的多种用途，用于治疗癌症。
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3.发明授权公开(公告)号：US09132152B2
公开(公告)日：2015-09-15
申请号：US13369997
申请日：2012-02-09
申请人： Lin He , Yong Jin Choi , Chao-Po Lin , Gregory J. Hannon , Xingyue He
发明人： Lin He , Yong Jin Choi , Chao-Po Lin , Gregory J. Hannon , Xingyue He
CPC分类号： A61K35/12 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/65 , C12N2506/13 , C12N2510/00
摘要： The present disclosure provides a method of generating an induced pluripotent stem cell; as well as nucleic acids and genetically modified host cells useful in generating iPSCs. The present disclosure provides iPSCs, and methods of use of same.
摘要翻译： 本公开提供了产生诱导多能干细胞的方法; 以及可用于产生iPSC的核酸和遗传修饰的宿主细胞。 本公开提供了iPSC及其使用方法。
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4.发明申请公开(公告)号：US20120207723A1
公开(公告)日：2012-08-16
申请号：US13369997
申请日：2012-02-09
申请人： Lin He , Yong Jin Choi , Chao-Po Lin , Gregory J. Hannon , Xingyue He
发明人： Lin He , Yong Jin Choi , Chao-Po Lin , Gregory J. Hannon , Xingyue He
CPC分类号： A61K35/12 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/65 , C12N2506/13 , C12N2510/00
摘要： The present disclosure provides a method of generating an induced pluripotent stem cell; as well as nucleic acids and genetically modified host cells useful in generating iPSCs. The present disclosure provides iPSCs, and methods of use of same.
摘要翻译： 本公开提供了产生诱导多能干细胞的方法; 以及可用于产生iPSC的核酸和遗传修饰的宿主细胞。 本公开提供了iPSC及其使用方法。
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