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15 条记录 (耗时 0.109 秒)

    Hydroxyalkylarylamide Derivatives
    9.
    发明申请
    Hydroxyalkylarylamide Derivatives 审中-公开
    羟烷基芳基酰胺衍生物

    公开(公告)号：US20090062297A1

    公开(公告)日：2009-03-05

    申请号：US12087623

    申请日：2007-01-08

    申请人： Richard W. Heidebrecht ,  Thomas A. Miller ,  Kevin J. Wilson ,  David J. Witter ,  Jonathan Grimm

    发明人： Richard W. Heidebrecht ,  Thomas A. Miller ,  Kevin J. Wilson ,  David J. Witter ,  Jonathan Grimm

    IPC分类号： A61K31/496 ,  C07D333/24 ,  A61K31/381 ,  A61K31/422 ,  C07D413/12 ,  C07D333/70

    CPC分类号： C07D333/70 ,  C07D333/20 ,  C07D413/12

    摘要： The present invention relates to a novel class of hydroxyalkylarylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

    摘要翻译： 本发明涉及一类新的羟烷基芳基酰胺衍生物。 本发明化合物可用于治疗癌症。 氟化芳基酰胺衍生物还可以抑制组蛋白脱乙酰酶，并且适用于选择性诱导终末分化，并阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如 神经退行性疾病 本发明进一步提供包含异羟肟酸衍生物和这些药物组合物的安全投药方案的药物组合物，它们易于遵循，并且其在体内导致治疗有效量的异羟肟酸衍生物。

    Set based item recommendation system
    10.
    发明授权
    Set based item recommendation system 有权
    设置项目推荐系统

    公开(公告)号：US08868596B2

    公开(公告)日：2014-10-21

    申请号：US13451827

    申请日：2012-04-20

    申请人： Vladimir Zelevinsky ,  Jonathan Grimm

    发明人： Vladimir Zelevinsky ,  Jonathan Grimm

    IPC分类号： G06F17/30

    CPC分类号： G06Q30/0631 ,  G06F17/30867

    摘要： A system for generating one or more recommended items for a user receives a target items set for the user which includes two or more target items. The system then queries a database of a plurality of related items sets using the target items set, where each related items set comprises a plurality of related items. In response to the querying, the system retrieves one or more similar items sets from the plurality of related item sets, each similar items set being similar to the target items set. The system then performs a union of the similar items sets to generate the recommended items.

    摘要翻译： 用于为用户生成一个或多个推荐项目的系统接收包括两个或多个目标项目的用户的目标项集合。 然后，系统使用目标项集合查询多个相关项目集合的数据库，其中每个相关项集合包括多个相关项目。 响应于查询，系统从多个相关项目集中检索一个或多个类似的项目集合，每个相似项目集合与目标项集合相似。 然后，系统执行类似项目集合的并集以生成推荐项目。