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公开(公告)号：US09950103B2
公开(公告)日：2018-04-24
申请号：US15060405
申请日：2016-03-03
申请人： Micromedics Inc.
IPC分类号： A61M1/16 , A61M1/34 , A61K38/38 , A61K33/44 , A61K31/795
CPC分类号： A61M1/1633 , A61K31/795 , A61K33/44 , A61K38/38 , A61M1/1654 , A61M1/1676 , A61M1/1698 , A61M1/3413 , A61M1/3417 , A61M1/3431 , A61M1/3479 , A61M1/3482 , A61M1/3496 , A61M2202/07 , A61M2202/08
摘要： A combination kidney and liver dialysis system and method provides a portable, lightweight hemodialysis device that removes uremic toxins, hepatic toxins, water, and impurities from the blood. The method comprises separating the blood into a plasma portion and a cellular portion, immediately returning the cellular portion to the body, providing large volumes of replacement fluids, diluting the plasma portion with replacement fluids, and then manipulating the plasma portion of the blood to pass through hemoperfusion membranes, hemodiafiltration membranes, and extracorporeal membrane oxygenation membranes. Dialysis is performed on the plasma portion of the blood with an albumin dialyzer against an albumin dialysate and a high molecular weight cut off membrane. Dialysis is performed on the plasma portion of blood with a lipid dialysate comprising 10-30% lipid composition, and a high flux dialyzer. The system can also use any form of dialysis technology including hollow fiber, flat plate and microfluidic technology.
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公开(公告)号：US20170252488A1
公开(公告)日：2017-09-07
申请号：US15060485
申请日：2016-03-03
申请人： Micromedics Inc.
IPC分类号： A61L27/60 , A61L27/18 , A61L27/56 , A61M35/00 , A61L27/22 , A61L27/34 , A61F13/02 , A61L27/54 , A61L27/26
CPC分类号： A61L27/60 , A61F13/0216 , A61F13/022 , A61F13/0226 , A61F2013/0017 , A61F2013/00285 , A61L27/18 , A61L27/22 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/104 , A61L2300/404 , A61L2300/412 , A61L2300/608 , A61L2420/08 , A61L2430/16 , A61L2430/34 , A61M35/00 , A61M2202/0208 , C08L83/04
摘要： A scalable microfluidic based artificial skin covers a variety of wounds while also providing efficient healing of the wounds. The artificial skin comprises a plurality of microfluidic panels separated by semi-permeable membranes, and also comprising a plurality of micro-pumps and micro-channels for carrying healing fluids in proximity to the wound on the natural skin. The panels form detachable patches that are inert and biocompatible. The panels are fabricated from polydimethylsiloxane materials and impregnated with silver nanocrystalline powder. A first panel partially engages the natural skin, partially supported by micro-pillars. Large micro-channels carry contaminants from the wound. A second panel and an optional third panel having micro-channels that carry healing fluids to the wound. A first and second semi-permeable membrane regulate passage of fluids, cellular components, and debris between the panels. An inlet port enables passage of healing fluids to the wound. An outlet port enables discharge of contaminants.
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公开(公告)号：US09889236B2
公开(公告)日：2018-02-13
申请号：US15060485
申请日：2016-03-03
申请人： Micromedics Inc.
IPC分类号： A61L27/60 , A61L27/54 , A61L27/18 , A61L27/56 , A61L27/26 , A61L27/22 , A61L27/34 , A61F13/02 , A61M35/00 , A61F13/00
CPC分类号： A61L27/60 , A61F13/0216 , A61F13/022 , A61F13/0226 , A61F2013/0017 , A61F2013/00285 , A61L27/18 , A61L27/22 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/104 , A61L2300/404 , A61L2300/412 , A61L2300/608 , A61L2420/08 , A61L2430/16 , A61L2430/34 , A61M35/00 , A61M2202/0208 , C08L83/04
摘要： A scalable microfluidic based artificial skin covers a variety of wounds while also providing efficient healing of the wounds. The artificial skin comprises a plurality of microfluidic panels separated by semi-permeable membranes, and also comprising a plurality of micro-pumps and micro-channels for carrying healing fluids in proximity to the wound on the natural skin. The panels form detachable patches that are inert and biocompatible. The panels are fabricated from polydimethylsiloxane materials and impregnated with silver nanocrystalline powder. A first panel partially engages the natural skin, partially supported by micro-pillars. Large micro-channels carry contaminants from the wound. A second panel and an optional third panel having micro-channels that carry healing fluids to the wound. A first and second semi-permeable membrane regulate passage of fluids, cellular components, and debris between the panels. An inlet port enables passage of healing fluids to the wound. An outlet port enables discharge of contaminants.
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公开(公告)号：US20170252497A1
公开(公告)日：2017-09-07
申请号：US15060405
申请日：2016-03-03
申请人： Micromedics Inc.
CPC分类号： A61M1/1633 , A61K31/795 , A61K33/44 , A61K38/38 , A61M1/1654 , A61M1/1676 , A61M1/1698 , A61M1/3413 , A61M1/3417 , A61M1/3431 , A61M1/3479 , A61M1/3482 , A61M1/3496 , A61M2202/07 , A61M2202/08
摘要： A combination kidney and liver dialysis system and method provides a portable, lightweight hemodialysis device that removes uremic toxins, hepatic toxins, water, and impurities from the blood. The method comprises separating the blood into a plasma portion and a cellular portion, immediately returning the cellular portion to the body, providing large volumes of replacement fluids, diluting the plasma portion with replacement fluids, and then manipulating the plasma portion of the blood to pass through hemoperfusion membranes, hemodiafiltration membranes, and extracorporeal membrane oxygenation membranes. Dialysis is performed on the plasma portion of the blood with an albumin dialyzer against an albumin dialysate and a high molecular weight cut off membrane. Dialysis is performed on the plasma portion of blood with a lipid dialysate comprising 10-30% lipid composition, and a high flux dialyzer. The system can also use any form of dialysis technology including hollow fiber, flat plate and microfluidic technology.
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公开(公告)号：US11596901B2
公开(公告)日：2023-03-07
申请号：US16888187
申请日：2020-05-29
申请人： Micromedics Inc.
IPC分类号： B01D63/08 , A61F2/02 , A61M1/16 , A61M1/34 , B01D61/24 , B01D61/50 , B01D61/02 , B01D61/42 , B01D61/48
摘要： A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.
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公开(公告)号：US10773214B2
公开(公告)日：2020-09-15
申请号：US15060251
申请日：2016-03-03
申请人： Micromedics Inc.
IPC分类号： B01D63/08 , B01D61/50 , A61F2/02 , A61F2/04 , A61M1/16 , A61M1/34 , B01D61/24 , B01D61/42 , B01D61/02 , B01D61/48
摘要： A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.
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公开(公告)号：US20210213389A1
公开(公告)日：2021-07-15
申请号：US16888187
申请日：2020-05-29
申请人： Micromedics Inc.
摘要： A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel ad/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.
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公开(公告)号：US20170252701A1
公开(公告)日：2017-09-07
申请号：US15060251
申请日：2016-03-03
申请人： Micromedics Inc.
CPC分类号： B01D63/088 , A61F2/022 , A61M1/1601 , A61M1/1621 , A61M1/1696 , A61M1/1698 , A61M1/3413 , A61M1/3417 , A61M1/3496 , A61M2205/0244 , B01D61/025 , B01D61/243 , B01D61/422 , B01D61/425 , B01D61/48 , B01D61/50 , B01D63/085 , B01D2311/25 , B01D2311/2623 , B01D2311/2626 , B01D2311/2649 , B01D2311/2692 , B01D2313/18 , B01D2313/38 , B01D2313/54 , B01D2315/16
摘要： A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.
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