公开(公告)号：US20150152481A1

公开(公告)日：2015-06-04

申请号：US14554720

申请日：2014-11-26

申请人： Micronics, Inc.

发明人： C. Frederick Battrell ,  Denise Maxine Hoekstra ,  Joan Haab ,  John R. Williford ,  Sabrina N. Gates ,  Elizabeth R. Leber ,  Isaac Sprague

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q2527/125

摘要： Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.

摘要翻译： 描述制造方法和组合物用于生产具有用于分子生物学测试的载体试剂的自含微流控盒装置。 敏感试剂以干燥形式储存而不进行冻干或冷冻，并在使用时与生物样品或样品洗脱液在使用时重构。 制造方法包括片和卷制造方法，其中将试剂印刷在适当位置并在凝胶玻璃化之前在单个微流体盒内密封。

公开(公告)号：US09938571B2

公开(公告)日：2018-04-10

申请号：US14554720

申请日：2014-11-26

申请人： Micronics, Inc.

发明人： C. Frederick Battrell ,  Denise Maxine Hoekstra ,  Joan Haab ,  John R. Williford ,  Sabrina N. Gunderson ,  Elizabeth R. Leber ,  Isaac Sprague

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q2527/125

摘要： Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point of use. Manufacturing methods include sheet and roll fabrication processes where the reagents are printed in place and sealed within individual microfluidic cartridges before gel vitrification.

公开(公告)号：US20150158026A1

公开(公告)日：2015-06-11

申请号：US14610493

申请日：2015-01-30

申请人： Micronics, Inc.

发明人： C. Frederick Battrell ,  John Gerdes ,  Stephen Mordue ,  Jason Capodanno ,  Denise Maxine Hoekstra ,  John R. Williford ,  John Clemmens

IPC分类号： B01L3/00 ,  G01N33/543

CPC分类号： B01L3/50273 ,  B01F11/0071 ,  B01F11/0074 ,  B01F13/0059 ,  B01L3/502738 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0638 ,  B01L2400/086 ,  F04B43/043 ,  F04B43/06 ,  G01N33/54366 ,  Y10T436/255

摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.