公开(公告)号：US20020127606A1

公开(公告)日：2002-09-12

申请号：US10023528

申请日：2001-12-17

申请人： Millennium Pharmaceuticals, Inc., a Delaware corporation

发明人： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

IPC分类号： G01N033/53 ,  C12Q001/18

CPC分类号： G01N33/56944 ,  C12Q1/18 ,  G01N2333/315 ,  G01N2500/04

摘要： Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed nullS-ylqF,null nullS-yqeG,null nullS-yybQ,null nullS-yerL,null and nullS-ysxC.null These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

摘要翻译： 公开了在肺炎链球菌中发现的对广泛细菌生存至关重要的基因。 这些基因被称为“S-ylqF”，“S-yqeG”，“S-yybQ”，“S-yerL”和“S-ysxC”。 它们编码的这些基因及其多肽，以及其同系物和直系同源物可用于鉴定用于治疗广谱细菌感染的抗菌剂。

公开(公告)号：US20030096267A1

公开(公告)日：2003-05-22

申请号：US10190279

申请日：2002-07-05

申请人： Millennium Pharmaceuticals, Inc., a Delaware corporation

发明人： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

IPC分类号： C12Q001/68 ,  G01N033/554 ,  G01N033/569 ,  C07H021/04 ,  C12Q001/18 ,  C12P021/02 ,  C12N001/21 ,  C07K014/315 ,  C12N015/74

CPC分类号： C07K14/32 ,  C07K14/245 ,  C07K14/3156

摘要： Disclosed are two genes, termed nullyphCnull and nullyqjK,null found in Streptococcus pneumoniae, which are essential for survival for a wide range of bacteria. These genes and the essential polypeptides that they encode, as well as homologs and orthologs thereof, can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

公开(公告)号：US20030228643A1

公开(公告)日：2003-12-11

申请号：US10423330

申请日：2003-04-25

申请人： Millennium Pharmaceuticals, Inc., a Delaware corporation

发明人： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

IPC分类号： G01N033/554 ,  G01N033/569

CPC分类号： G01N33/56944 ,  C12Q1/18 ,  G01N2333/315 ,  G01N2500/04

摘要： Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed nullS-ylqF,null nullS-yqeG,null nullS-yybQ,null nullS-yerL,null and nullS-ysxC.null These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

摘要翻译： 公开了在肺炎链球菌中发现的对广泛细菌生存至关重要的基因。 这些基因被称为“S-ylqF”，“S-yqeG”，“S-yybQ”，“S-yerL”和“S-ysxC”。 它们编码的这些基因及其多肽，以及其同系物和直系同源物可用于鉴定用于治疗广谱细菌感染的抗菌剂。

公开(公告)号：US20030092024A1

公开(公告)日：2003-05-15

申请号：US10154251

申请日：2002-05-22

申请人： Millennium Pharmaceuticals, Inc., a Delaware corporation

发明人： Philip Youngman ,  Christian Fritz ,  Christopher Murphy ,  Luz-Maria Guzman

IPC分类号： C12Q001/68 ,  C12N001/21 ,  C12N015/74 ,  C12Q001/18

CPC分类号： C07K14/3156 ,  C07K14/32

摘要： Disclosed are 23 genes, termed nullGEPnull genes, found in Streptococcus pneumonia, which are located within operons that are essential for survival. Also disclosed is a related essential gene found in Bacillus subtilis. These genes and the polypeptides that they encode, as well as homologs thereof, can be used to identify antibacterial agents for treating bacterial infections such as streptococcal pneumonia.

公开(公告)号：US20040235085A1

公开(公告)日：2004-11-25

申请号：US10884529

申请日：2004-07-02

申请人： Millennium Pharmaceuticals, Inc., a Delaware corporation

发明人： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

IPC分类号： C12Q001/18

CPC分类号： G01N33/56944 ,  C12Q1/18 ,  G01N2333/315 ,  G01N2500/04

摘要： Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed nullS-ylqF,null nullS-yqeG,null nullS-yybQ,null nullS-yerL,null and nullS-ysxC.null These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

摘要翻译： 公开了在肺炎链球菌中发现的对广泛细菌生存至关重要的基因。 这些基因被称为“S-ylqF”，“S-yqeG”，“S-yybQ”，“S-yerL”和“S-ysxC”。 它们编码的这些基因及其多肽，以及其同系物和直系同源物可用于鉴定用于治疗广谱细菌感染的抗菌剂。

公开(公告)号：US20020115591A1

公开(公告)日：2002-08-22

申请号：US10068080

申请日：2002-02-05

申请人： Millennium Pharmaceuticals, Inc., a Delaware corporation

发明人： Christian Fritz ,  Philip Youngman ,  Luz-Maria Guzman

IPC分类号： A01N037/18

CPC分类号： C07K14/3156 ,  A61K38/00 ,  C07K14/315 ,  C07K14/32 ,  C12Q1/18 ,  G01N33/9446

摘要： Disclosed is a gene, termed nullS-yneS,null found in Streptococcus pneumoniae, which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred to as nullyneSnull genes and polypeptides) can be used to identify antibacterial agents for treating a broad spectrum of bacterial infections.

摘要翻译： 公开了在肺炎链球菌中发现的称为“S-yneS”的基因，其对于广泛的细菌的存活是必需的。 该基因及其编码的S-yneS多肽，以及其同系物和直系同源物（统称为“yneS”基因和多肽）可用于鉴定用于治疗广谱细菌感染的抗菌剂。