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22 条记录 (耗时 0.024 秒)

    Treatment of antibiotic-resistant bacteria infection
    1.
    发明授权
    Treatment of antibiotic-resistant bacteria infection 有权
    治疗抗生素耐药细菌感染

    公开(公告)号：US08211909B2

    公开(公告)日：2012-07-03

    申请号：US12206060

    申请日：2008-09-08

    申请人： Ming-Chu Hsu ,  Chi-Hsin Richard King ,  Shu-Jen Chen ,  Luke Lin

    发明人： Ming-Chu Hsu ,  Chi-Hsin Richard King ,  Shu-Jen Chen ,  Luke Lin

    IPC分类号： A61K31/47

    CPC分类号： A61K31/4709

    摘要： This invention relates to a method of treating infection by methicillin-nonsusceptibale bacteria, vancomycin-nonsusceptibale bacteria, penicillin-nonsusceptibale bacteria, clarithromycin-nonsusceptibale bacteria, or metronidazole-nonsusceptibale bacteria by administering to a subject in need thereof an effective amount of a compound of the following formula:

    摘要翻译： 本发明涉及一种通过向有需要的受试者施用有效量的化合物的方法来治疗甲氧西林非感染性细菌，万古霉素 - 非感染性细菌，青霉素 - 非吸收性细菌，克拉霉素 - 非吸收性细菌或甲硝唑 - 非吸收性细菌的感染， 以下公式：

    TREATMENT OF ANTIBIOTIC-RESISTANT BACTERIA INFECTION
    2.
    发明申请
    TREATMENT OF ANTIBIOTIC-RESISTANT BACTERIA INFECTION 有权
    抗菌细菌感染的治疗

    公开(公告)号：US20100004282A1

    公开(公告)日：2010-01-07

    申请号：US12206060

    申请日：2008-09-08

    申请人： Ming-Chu Hsu ,  Chi-Hsin Richard King ,  Shu-Jen Chen ,  Luke Lin

    发明人： Ming-Chu Hsu ,  Chi-Hsin Richard King ,  Shu-Jen Chen ,  Luke Lin

    IPC分类号： A61K31/4709 ,  A61P31/12

    CPC分类号： A61K31/4709

    摘要： This invention relates to a method of treating infection by methicillin-nonsusceptibale bacteria, vancomycin-nonsusceptibale bacteria, penicillin-nonsusceptibale bacteria, clarithromycin-nonsusceptibale bacteria, or metronidazole-nonsusceptibale bacteria by administering to a subject in need thereof an effective amount of a compound of the following formula:

    摘要翻译： 本发明涉及一种通过向有需要的受试者施用有效量的化合物的方法来治疗甲氧西林非感染性细菌，万古霉素 - 非感染性细菌，青霉素 - 非吸收性细菌，克拉霉素 - 非吸收性细菌或甲硝唑 - 非吸收性细菌的感染， 以下公式：

    Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
    8.
    发明授权
    Indol-3-YL-2-oxoacetamide compounds and methods of use thereof 有权

    公开(公告)号：US06903104B2

    公开(公告)日：2005-06-07

    申请号：US10310711

    申请日：2002-12-05

    申请人： Chiung-Tong Chen ,  Shu-Jen Chen ,  Ming-Chu Hsu ,  Der-Ren Hwang ,  Wen-Tai Li ,  Chu-Chung Lin

    发明人： Chiung-Tong Chen ,  Shu-Jen Chen ,  Ming-Chu Hsu ,  Der-Ren Hwang ,  Wen-Tai Li ,  Chu-Chung Lin

    IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/405 ,  C07D407/12 ,  C07D413/12

    CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

    摘要： The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula. In this formula, each R1 is independently isoxazolyl, thiazolyl, isothiazolyl, 1,3,4-thiadiazolyl, 1,3-benzothiazolyl, quinolyl, isoquinolyl, thionaphthenyl, or benzofuranyl, each being optionally substituted with 1-6 independent R5; or when taken together with R2 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R2 is independently H, C1-C10 alkyl, or aryl, each being optionally substituted with 1-4 independent R5; or when taken together with R1 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R3 is independently C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, pyridyl, or heterocyclyl, each being optionally substituted with 1-4 independent R5. Each R4 is independently H, NO2, halo, CN, R7, OR7, CO2R7, SR7, NR7R7, C(O)R7, C(O)NR7R7, OC(O)R7, S(O)2R7, S(O)2NR7R7, NR7C(O)NR7R7, NR7C(O)R7, NR7(COOR7), NR7S(O)2NR7R7, NR7S(O)2R7, or S(O)2OR7.