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1.发明申请公开(公告)号：US20140066410A1
公开(公告)日：2014-03-06
申请号：US14001074
申请日：2012-02-23
申请人： Ming-Ming Zhou , Michael Ohlmeyer , Shiraz Mujtaba , Alexander Plotnikov , David Kastrinsky , Guangtao Zhang
发明人： Ming-Ming Zhou , Michael Ohlmeyer , Shiraz Mujtaba , Alexander Plotnikov , David Kastrinsky , Guangtao Zhang
IPC分类号： C07D213/76 , C07C311/44
CPC分类号： C07D213/76 , A61K31/18 , A61K45/06 , C07C311/44 , A61K2300/00
摘要： This disclosure relates generally to compounds and compositions comprising one or more diphenylethylene, diphenylethylyne, and azobenzene analogs. These compounds are useful for treating diseases associated with NF-kB and p53 activity, such as cancer and inflammatory disease.
摘要翻译： 本公开一般涉及包含一种或多种二苯基乙烯，二苯基乙烯基和偶氮苯类似物的化合物和组合物。 这些化合物可用于治疗与NF-kB和p53活性相关的疾病，如癌症和炎性疾病。
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公开(公告)号：US20120028912A1
公开(公告)日：2012-02-02
申请号：US12590069
申请日：2009-11-02
申请人： Ming-Ming Zhou , Aneel K. Aggarwal , Melanie Ott , Eric Verdin
发明人： Ming-Ming Zhou , Aneel K. Aggarwal , Melanie Ott , Eric Verdin
IPC分类号： A61K38/10 , A61K31/135 , A61P31/18 , A61K31/16 , A61K31/352 , A61K38/08 , A61K31/195
CPC分类号： A61K9/0078 , A61K31/00 , A61K38/08 , A61K38/10 , A61K38/21 , A61K2300/00
摘要： The present invention features compounds useful for and methods for preventing or inhibiting the binding of bromodomains to acetyl-lysine residues of proteins and methods for treating HIV infection and HIV related disease.
摘要翻译： 本发明的特征在于可用于预防或抑制溴结构域与蛋白质的乙酰赖氨酸残基的结合的方法和用于治疗HIV感染和HIV相关疾病的方法。
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公开(公告)号：US07919276B1
公开(公告)日：2011-04-05
申请号：US09510314
申请日：2000-02-22
申请人： Ming-Ming Zhou , Aneel K. Aggarwal
发明人： Ming-Ming Zhou , Aneel K. Aggarwal
IPC分类号： C12P19/34
CPC分类号： C07K14/4705 , C12N9/1029 , C12Y203/01048
摘要： The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides a binding partner for the bromodomain. In addition, the present invention provides methodology for related drug discovery using high throughput drug screening or structure based rational drug design using the three-dimensional data.
摘要翻译： 本发明提供了通过NMR光谱测定的溴结构域的结构测定。 本发明还提供了用于溴结构域的结合配偶体。 此外，本发明提供使用高通量药物筛选或使用三维数据的基于结构的合理药物设计的相关药物发现的方法。
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4.发明申请INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION 审中-公开通过破坏尿激酶促血清激酶受体整合相互作用诱导和/或维持肿瘤多药公开(公告)号：US20100249184A1
公开(公告)日：2010-09-30
申请号：US12531502
申请日：2008-03-17
IPC分类号： A61K31/47 , A61K31/4402 , C12N5/09 , G01N33/574 , G06G7/60
CPC分类号： A61K31/4709
摘要： The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound that disrupts interaction between urokinase plasminogen activator receptor and integrin, thereby including cancer cells into dormancy and treating cancer in the subject. Also disclosed is a method of disrupting interaction between integrin and urokinase plasminogen activator receptor on cancer cells. The present invention also relates to a method of screening for compounds effective in inducing tumor dormancy and treating cancer in a subject.
摘要翻译： 本发明涉及诱导癌细胞进入休眠并在受试者中治疗癌症的方法。 该方法包括向受试者施用有效量的化合物，其破坏尿激酶纤溶酶原激活剂受体和整联蛋白之间的相互作用，从而将癌细胞包含在休眠状态并治疗受试者的癌症。 还公开了破坏癌细胞上整联蛋白和尿激酶纤溶酶原激活物受体之间的相互作用的方法。 本发明还涉及筛选在受试者中有效诱导肿瘤休眠和治疗癌症的化合物的方法。
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公开(公告)号：US07108984B2
公开(公告)日：2006-09-19
申请号：US09757415
申请日：2001-01-09
申请人： Ming-Ming Zhou , Mitchell Goldfarb
发明人： Ming-Ming Zhou , Mitchell Goldfarb
IPC分类号： G01N33/53
CPC分类号： C07K14/71 , C07K14/475 , C07K2319/00 , G06F19/16
摘要： The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.
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公开(公告)号：US07645857B2
公开(公告)日：2010-01-12
申请号：US11183567
申请日：2005-07-18
申请人： Ming-Ming Zhou , Mitchell Goldfarb
发明人： Ming-Ming Zhou , Mitchell Goldfarb
IPC分类号： C07K9/00 , C07K4/12 , C07K14/435
CPC分类号： C07K14/71 , C07K14/475 , C07K2319/00 , G06F19/16
摘要： The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.
摘要翻译： 本发明提供SNT和FGFR的片段，其可以形成可通过NMR光谱法进行结构测定的结合复合物。 作为本发明的一部分，还包括三维结构数据。 另外，本发明提供了使用三维数据的基于相关结构的合理药物设计方法。 还提供了片段的核苷酸和氨基酸序列。
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公开(公告)号：US07589167B2
公开(公告)日：2009-09-15
申请号：US09784553
申请日：2001-02-16
申请人： Ming-Ming Zhou , Aneel K. Aggarwal , Eric Verdin , Melanie Ott
发明人： Ming-Ming Zhou , Aneel K. Aggarwal , Eric Verdin , Melanie Ott
CPC分类号： A61K31/198 , C07K2299/00 , C12N9/1029 , C12Y203/01048 , G01N33/56988 , G01N2333/163 , G01N2500/02
摘要： The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides binding partners for the bromodomain. The present invention further provides the structural determination of the Tat-P/CAF binding complex determined by NMR spectroscopy. In addition, the present invention provides methodology for related drug discovery using high throughput drug screening or structure based rational drug design using the three-dimensional data.
摘要翻译： 本发明提供了通过NMR光谱测定的溴结构域的结构测定。 本发明还提供了溴结构域的结合配偶体。 本发明还提供了通过NMR光谱测定的Tat-P / CAF结合复合物的结构测定。 此外，本发明提供使用高通量药物筛选或使用三维数据的基于结构的合理药物设计的相关药物发现的方法。
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公开(公告)号：US20060019296A1
公开(公告)日：2006-01-26
申请号：US11183567
申请日：2005-07-18
申请人： Ming-Ming Zhou , Mitchell Goldfarb
发明人： Ming-Ming Zhou , Mitchell Goldfarb
CPC分类号： C07K14/71 , C07K14/475 , C07K2319/00 , G06F19/16
摘要： The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.
摘要翻译： 本发明提供SNT和FGFR的片段，其可以形成可通过NMR光谱法进行结构测定的结合复合物。 作为本发明的一部分，还包括三维结构数据。 另外，本发明提供了使用三维数据的基于相关结构的合理药物设计方法。 还提供了片段的核苷酸和氨基酸序列。
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