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1.发明申请公开(公告)号：US20140066410A1
公开(公告)日：2014-03-06
申请号：US14001074
申请日：2012-02-23
申请人： Ming-Ming Zhou , Michael Ohlmeyer , Shiraz Mujtaba , Alexander Plotnikov , David Kastrinsky , Guangtao Zhang
发明人： Ming-Ming Zhou , Michael Ohlmeyer , Shiraz Mujtaba , Alexander Plotnikov , David Kastrinsky , Guangtao Zhang
IPC分类号： C07D213/76 , C07C311/44
CPC分类号： C07D213/76 , A61K31/18 , A61K45/06 , C07C311/44 , A61K2300/00
摘要： This disclosure relates generally to compounds and compositions comprising one or more diphenylethylene, diphenylethylyne, and azobenzene analogs. These compounds are useful for treating diseases associated with NF-kB and p53 activity, such as cancer and inflammatory disease.
摘要翻译： 本公开一般涉及包含一种或多种二苯基乙烯，二苯基乙烯基和偶氮苯类似物的化合物和组合物。 这些化合物可用于治疗与NF-kB和p53活性相关的疾病，如癌症和炎性疾病。
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公开(公告)号：US11291644B2
公开(公告)日：2022-04-05
申请号：US14018012
申请日：2013-09-04
IPC分类号： A61K31/282 , A61K9/00 , A61K33/243
摘要： The described invention provides methods for treating pulmonary cancer in a subject, by administering to the subject by inhalation a composition of inhalational lipid cisplatin (ILC) comprising a lipid-complexed cisplatin.
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3.发明授权Pseudonocardia sp. and method for preparing deoxynyboquinone by utilizing same 有权假诺卡氏菌 以及通过利用该方法制备脱氧鸟烷酮的方法公开(公告)号：US09322040B2
公开(公告)日：2016-04-26
申请号：US13885568
申请日：2011-09-01
申请人： Si Zhang , Changsheng Zhang , Xinpeng Tian , Sumei Li , Wenjun Zhang , Haibo Zhang , Guangtao Zhang , Hao Yin , Jianhua Ju
发明人： Si Zhang , Changsheng Zhang , Xinpeng Tian , Sumei Li , Wenjun Zhang , Haibo Zhang , Guangtao Zhang , Hao Yin , Jianhua Ju
CPC分类号： C12P17/182 , C12N1/20 , C12R1/01
摘要： The invention discloses a Pseudonocardia sp. and a method for preparing Deoxynyboquinone by utilizing the same. Pseudonocardia sp. SCSIO 01299 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011255 on Jul. 18, 2011. The Pseudonocardia sp. SCSIO 01299 can produce antibiotic Deoxynyboquinone, so that the Pseudonocardia sp. SCSIO 01299 can be utilized for preparing Deoxynyboquinone and a new way is provided for producing antibiotic Deoxynyboquinone with anti-tumor activity.
摘要翻译： 本发明公开了一种假诺卡氏菌 以及通过利用该方法制备脱氧尼龙醌的方法。 假诺卡氏菌 SCSIO 01299于2011年7月18日收集在中国文化收藏中心（CCTCC）（地址：武汉市武汉市，中国武汉市），收集了CCTCC号：2011255号。 SCSIO 01299可以生产抗生素脱氧尼龙醌，使得心绞痛 SCSIO 01299可以用于制备脱氧尼龙醌，并提供了一种新的方法来生产具有抗肿瘤活性的抗生素脱氧尼龙。
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4.发明申请公开(公告)号：US20140065205A1
公开(公告)日：2014-03-06
申请号：US14018012
申请日：2013-09-04
IPC分类号： A61K31/282 , A61K47/48
CPC分类号： A61K31/282 , A61K9/0078 , A61K33/24
摘要： The described invention provides methods for treating pulmonary cancer in a subject, by administering to the subject by inhalation a composition of inhalational lipid cisplatin (ILC) comprising a lipid-complexed cisplatin.
摘要翻译： 所述发明提供了通过向受试者施用包含脂质复合顺铂的吸入性脂质顺铂（ILC）的组合物来给予受试者治疗受试者的肺癌的方法。
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公开(公告)号：US20090018141A1
公开(公告)日：2009-01-15
申请号：US12135575
申请日：2008-06-09
申请人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
发明人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
IPC分类号： A61K31/496 , A61K31/17 , C07C275/40 , A61K31/404 , C07D209/42 , C07D403/12 , C12N9/99 , A61P3/10 , A61K31/444 , C07D401/12 , A61K31/495 , C07D241/04
CPC分类号： C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法 可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。
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公开(公告)号：US08765802B2
公开(公告)日：2014-07-01
申请号：US12135575
申请日：2008-06-09
申请人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
发明人： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self
IPC分类号： A61K31/40 , C07D209/42
CPC分类号： C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法 可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。
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7.发明申请Pseudonocardia SP. And Method For Preparing Deoxynyboquinone By Utilizing Same 有权假诺卡氏菌 和通过使用它来制备脱氧苯醌的方法公开(公告)号：US20130230890A1
公开(公告)日：2013-09-05
申请号：US13885568
申请日：2011-09-01
申请人： Si Zhang , Changsheng Zhang , Xinpeng Tian , Sumei Li , Wenjun Zhang , Haibo Zhang , Guangtao Zhang , Hao Yin , Jianhua Ju
发明人： Si Zhang , Changsheng Zhang , Xinpeng Tian , Sumei Li , Wenjun Zhang , Haibo Zhang , Guangtao Zhang , Hao Yin , Jianhua Ju
CPC分类号： C12P17/182 , C12N1/20 , C12R1/01
摘要： The invention discloses a Pseudonocardia sp. and a method for preparing Deoxynyboquinone by utilizing the same. Pseudonocardia sp. SCSIO 01299 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011255 on Jul. 18, 2011. The Pseudonocardia sp. SCSIO 01299 can produce antibiotic Deoxynyboquinone, so that the Pseudonocardia sp. SCSIO 01299 can be utilized for preparing Deoxynyboquinone and a new way is provided for producing antibiotic Deoxynyboquinone with anti-tumor activity.
摘要翻译： 本发明公开了一种假诺卡氏菌 以及通过利用该方法制备脱氧尼龙醌的方法。 假诺卡氏菌 SCSIO 01299于2011年7月18日收集在中国文化收藏中心（CCTCC）（地址：武汉市武汉市，中国武汉市），收集了CCTCC号：2011255号。 SCSIO 01299可以生产抗生素脱氧尼龙醌，使得心绞痛 SCSIO 01299可以用于制备脱氧尼龙醌，并提供了一种新的方法来生产具有抗肿瘤活性的抗生素脱氧尼龙。
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